The Value of SII in Predicting the Mortality of Patients with Heart Failure

Abstract

Background. The main purpose of this study was to explore the predictive value of the systemic immune inflammation index (SII), a novel clinical marker, in heart failure (HF) patients. Methods. Critically ill patients with HF were identified from the Medical Information Mart for Intensive Care III (MIMIC III) database. Patients were divided into three groups according to tertiles of SII (group 1, group 2, group 3). We used Kaplan-Meier curves and Cox proportional hazards regression models to evaluate the association between the SII and all-cause mortality in HF. Subgroup analysis was used to verify the predictive effect of the SII on mortality. Results. This study included 9107 patients with a diagnosis of HF from the MIMIC III database. After 30, 60, 180, and 365 days of follow-up, 25.60%, 32.10%, 41.30%, and 47.50% of the patients in group 3 had died. Using the Kaplan-Meier curve, we observed that patients with higher SII values had a shorter survival time (log rank p < 0.001 ). The Cox proportional hazards regression model adjusted for all possible confounders and indicated that the higher SII group had a higher mortality (30-day: HR = 1.304 , 95 % CI = 1.161 − 1.465 , 60-day: HR = 1.266 , 95% CI = 1.120 − 1.418 , 180-day: HR = 1.274 , 95 % CI = 1.163 − 1.395 , and 365-day: HR = 1.255 , 95 % CI = 1.155 − 1.364 ). Conclusions. SII values could be used as a predictor of prognosis in critically ill patients with HF.

The Association between Systemic Immune-Inflammation Index and All-Cause Mortality in Acute Ischemic Stroke Patients: Analysis from the MIMIC-IV Database

“…This marker was shown to reflect the severity of systemic inflammation in patients with carcinoma [ 11 ] and has high prognostic values in different types of cancer [ 12 , 13 ]. SII was recently reported to be positively associated with mortality in patients with heart failure [ 14 ]. Some studies have shown that it is related to the incidence, severity, and prognosis of AIS [ 15 , 16 ], but it is unknown whether it is related to the mortality of patients who stay in the intensive care unit.…”

A retrospective cohort study on the association between early coagulation disorder and short-term all-cause mortality of critically ill patients with congestive heart failure

“…Besides, soluble suppression of tumorigenicity 2 related to inflammation and fibrosis has become a leading prognostic biomarker for the allcause and cardiovascular death of acute heart failure, but its application is limited due to the inaccessibility in clinical practice (30,31). And the effort to identifying some simple and effective indicators is also of significance (32).…”

Prognostic role of the systemic immune-inflammation index in biliary tract cancers: a meta-analysis of 3,515 patients

“…For example, a recent retrospective cohort study showed that the SII was associated in a J-shaped pattern with all-cause mortality among critically ill patients with acute kidney injury [43]. Another study indicated that patients with heart failure with higher SII values had a shorter survival time [44]. Xia et al demonstrated that the SII is a potential new diagnostic biomarker in patients with severe COVID-19 in a study including 125 patients diagnosed with COVID-19 [45].…”