The Value of <scp>d</scp>-Dimer Level in Predicting Contrast-Induced Acute Kidney Injury in Patients With Acute ST-Segment Elevation Myocardial Infarction After PCI

Luo, Erfei; Wang, Dong; Liu, Bo; Hou, Jiantong; Yan, Gaoliang; Tang, Chengchun

doi:10.1177/1076029620944492

Cited by 6 publications

(9 citation statements)

References 29 publications

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“…The best cut-off value was 640 ng/mL. In the subgroup with no-reflow phenomenon, increased D-dimer predicted CVEs (OR 8.114, 95%CI 1.598–41.196, p = 0.012) Luo 2020 [ 19 ] STEMI 400 62.5 21 R 12 CVEs (all-cause death, TVR, MI, UA, HF, stroke or TIA) Groups (μg/L) 1: 74.0; 2: 146.0; 3: 256.5; 4: 576.0. The incidence of CVEs and all-cause mortality within 30 days ( p < 0.001), 6 months ( p = 0.001), and 1 year (p = 0.001) after PCI in the highest quartile of the D-dimer groups were higher than those in the other 3 groups.…”

Section: Methodsmentioning

confidence: 99%

D-dimer for risk stratification and antithrombotic treatment management in acute coronary syndrome patients: a systematic review and metanalysis

et al. 2021

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Background Data on the prognostic role of D-dimer in patients with acute coronary syndrome (ACS) are controversial. Our aim was to summarize current evidence on the association between D-dimer levels and short/long-term poor prognosis of ACS patients. We also investigated the association between D-dimer and no-reflow phenomenon. Methods Systematic review and metanalysis of observational studies including ACS patients and reporting data on D-dimer levels. PubMed and SCOPUS databases were searched. Data were combined with hazard ratio (HR) and metanalysed. The principal endpoint was a composite of cardiovascular events (CVEs) including myocardial infarction, all-cause and cardiovascular mortality. Results Overall, 32 studies included in the systematic review with 28,869 patients. Of them, 6 studies investigated in-hospital and 26 studies long-term outcomes. Overall, 23 studies showed positive association of high D-dimer levels with CVEs. D-dimer levels predicted poor prognosis in all studies reporting in-hospital outcomes. Five studies satisfied inclusion criteria and were included in the metanalysis, with a total of 8616 patients. Median follow-up was 13.2 months with 626 CVEs. The pooled HR for D-dimer levels and CVEs was 1.264 (95% CI 1.134–1.409). Five out of 7 studies (4195 STEMI patients) investigating the association between D-dimer levels and no-reflow showed a positive correlation of D-dimer levels with no-reflow. Conclusions In patients with ACS, D-dimer was associated with higher in-hospital and short/long-term complications. D-dimer was also higher in patients with no-reflow phenomenon. The use of D-dimer may help to identify patients with residual thrombotic risk after ACS. Trial registration The review protocol was registered in PROSPERO International Prospective Register of Systematic Reviews: CRD42021267233.

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Section: Methodsmentioning

confidence: 99%

D-dimer for risk stratification and antithrombotic treatment management in acute coronary syndrome patients: a systematic review and metanalysis

et al. 2021

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“…On the whole, the results obtained from the meta-analysis were statistically significant. To further analyze the reasons for heterogeneity, we found a decrease in heterogeneity, from 91 to 85%, after excluding Luo’s article 26 by the one-by-one exclusion method. When checking the sources of heterogeneity by selecting articles one by one, except for the slight fluctuations when excluding Luo’s articles, the results did not show any fluctuations; the decrease in heterogeneity was not significant, which indirectly indicates the relative robustness of the results.…”

Section: Resultsmentioning

confidence: 95%

“…We subjected 10 studies (14 data sets) to sensitivity analysis. The results showed that the heterogeneity of the articles excluding Luo’s article 26 changed and the results were relatively robust after excluding other articles. In the sensitivity analysis chart, we can see that the point estimation of other articles falls within the 95% CI of the total effect amount except for Luo’s research.…”

Section: Resultsmentioning

confidence: 96%

Effect of Serum Bilirubin Levels on Contrast-induced Acute Kidney Injury: A Systematic Evaluation and Meta-analysis

Lyu,

Miao,

Liu

et al. 2023

Angiology

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Contrast-induced acute kidney injury (CI-AKI) is an important complication following the use of iodinated contrast media. Bilirubin has a protective effect but may also aggravate CI-AKI. The purpose of this systematic review was to assess whether bilirubin is a risk factor for CI-AKI. We searched the databases PubMed, Embase, Web of Science, Cochrane Library, Scopus, Ovid Medline, CNKI (China National Knowledge Infrastructure), VPCS (Vip Paper Check System), Wanfang, and CBM (Chinese BioMedical Literature Database) from the initial date to May 6, 2023. We summarized the results by directly combining the effect-size odds ratio (OR) and 95% confidence interval (CI) and identified sources of heterogeneity through subgroup analysis, sensitivity analysis, and meta-regression analysis. A total of 10 studies (14 data sets) were included: 7 retrospective studies (10 data sets) and 3 prospective studies (4 data sets), involving 12776 participants. The incidence of CI-AKI of 16% (95% CI: 14-19%). Total bilirubin was positively associated with the occurrence of CI-AKI (OR = 1.80; 95% CI: 1.36-2.38). Both low and high bilirubin concentrations were risk factors for CI-AKI. The incidence of CI-AKI was higher in the low bilirubin group than in the high bilirubin group.

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“…Compared with plaques with thick fibrous caps, more plaque contents are released into the circulation during TCFA rupture, including inflammatory factors, cholesterol crystals, and necrotic material [ 24 ]. And these contents are risk factors for AKI [ 25 , 26 ]. TCFA has been shown mainly concentrated in the middle and distal segments of the anterior descending and gyral branches [ 23 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Score for Prediction of Acute Kidney Injury in Patients with Acute ST-Segment Elevation Myocardial Infarction

Miao

Lin²,

Zhao

2022

Disease Markers

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Background. Acute kidney injury (AKI) is an important comorbidity of ST-Segment Elevation Myocardial Infarction (STEMI) and worsens the prognosis. The purpose of this study was to investigate the relationship between clinical data, test results, surgical findings, and AKI in STEMI patients and to develop a simple, practical model for predicting the risk of AKI. Method. Prognostic prediction research with clinical risk score development was conducted. The data used for model development was derived from the database of the Henan Province Cardiovascular Disease Clinical Data and Sample Resource Bank Engineering Research Center. The data used for external validation was derived from the China Chest Pain Center database. The study endpoint was defined as the occurrence of AKI. Logistic regression analysis was used to identify independent predictors of AKI. Logistic coefficients of each predictor were used for score weighting and transformation. The predictive performance of the newly derived risk scores was validated, respectively, by receiver operating characteristic (ROC) regression in the development population and the external validation population. Result. A total of 364 patients, 57 (15.6%) with AKI and 307 (84.4%) without AKI, were included for score derivation. The validation crowd includes 88 STEMI patients in different institutions. A total of 11 potential predictors were explored under the multivariable logistic regression model. The new risk score was based on five final predictors which were age > 72 years , ejection fraction of no more than 40%, baseline serum creatinine > 102.7 mmol / L , red blood cell distribution width > 13.15 , and culprit lesion located in the middistal segment. With only five predictor variables, the score predicted the risk of AKI with the effective discriminative ability (area under the receiver operating characteristic curve (AuROC): 0.721, 95% confidence interval (CI): 0.652-0.790). In the external validation, the newly developed score confirmed a similar discrimination as the crowd used for derivation (AuROC: 0.731, 95% CI: 0.624-0.838). Conclusion. The newly developed score was proved to have good predictive performance and could be practically applied for risk stratification of AKI in STEMI patients.

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The Value of d-Dimer Level in Predicting Contrast-Induced Acute Kidney Injury in Patients With Acute ST-Segment Elevation Myocardial Infarction After PCI

Cited by 6 publications

References 29 publications

D-dimer for risk stratification and antithrombotic treatment management in acute coronary syndrome patients: a systematic review and metanalysis

D-dimer for risk stratification and antithrombotic treatment management in acute coronary syndrome patients: a systematic review and metanalysis

Effect of Serum Bilirubin Levels on Contrast-induced Acute Kidney Injury: A Systematic Evaluation and Meta-analysis

Risk Score for Prediction of Acute Kidney Injury in Patients with Acute ST-Segment Elevation Myocardial Infarction

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