The Value of Repeat Clostridium difficile Toxin Testing during and after an Outbreak of C difficile‐Associated Diarrhea

Abstract

The value of repeat CDTT, performed using a cell cytotoxicity assay, was low in the first three days after an initial negative result and was unchanged during a CDAD outbreak.

Akute Gastroenteritis im Kindes- und Erwachsenenalter

“…Abgesehen von der STEC-Epidemie (STEC: Shiga-Toxin exprimierende E. coli) in 2011 (s. "Hintergrund -STEC-Epidemie") spielt der Erreger bei Erwachsenen eher eine geringe Rolle als Auslöser einer Gastroenteritis. So sind auch die erfassten HUS-Fälle vorrangig bei Kindern unter 5 Jahren zu finden (46 von [38]. In den meisten Laboren kommt der GDH-EIA (Glutamatdehydrogenase-Enzymimmunoassay) in Kombination mit dem Toxin-EIA zum Einsatz.…”

The Simple Predictors of Pseudomembranous Colitis in Patients with Hospital-Acquired Diarrhea: A Prospective Observational Study

“…Compared with SAAD or CDAD, PMC has a poor prognosis and more severe clinical manifestations, such as ascites and transmural inflammation of the colon, 8 although severe CDAD can be associated with significant mortality. 9 , 10 For these reasons, medical treatments, such as oral administration of metronidazole or vancomycin, are usually recommended for C. difficile toxin-positive patients who have diarrhea despite antibiotic discontinuation, cannot discontinue antibiotics, and/or show evidence of colitis on colonoscopy. 11 Furthermore, careful sigmoidoscopy or colonoscopy can be recommended in advance for selected patients with severe clinical features who cannot wait for the results of a C. difficile -toxin test.…”