The value of red blood cell distribution width in diagnosis of patients with colorectal cancer

Yang, Dianyu; Quan, Wenqiang; Wu, Junlu; Ji, Xiaoyi; Dai, Yan; Xiao, Weidong; Chew, Helen K.; Sun, Zujun; Li, Dong

doi:10.1016/j.cca.2018.01.022

Cited by 38 publications

(49 citation statements)

References 21 publications

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“…Similar to previous studies, RDW is elevated in many malignant tumors. Yang et al compared RDW values in 85 patients with colorectal cancer and 54 patients with colon polyps. RDW was observed to increase in colorectal cancer patients, and RDW was significantly different at each stage of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

Zhang

Xie

Zhan

2019

Clinical Laboratory Analysis

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BackgroundRed blood cell distribution width (RDW) has attracted increasing attention in cancer. The aim of this study was to assess the changes of RDW in patients with invasive hydatidiform mole and analyze the relationship between RDW and invasive hydatidiform mole.MethodsA retrospective analysis was performed on 102 patients diagnosed as invasive hydatidiform mole in the First Affiliated Hospital of Guangxi Medical University from January 2009 to March 2018. A total of 120 healthy subjects were used as a control group. The Mann‐Whitney U test was used for comparison between the invasive hydatidiform mole and control groups. Comparison of RDW with other blood parameters was performed using Spearman's. The area under the ROC curve (AUC) and 95% confidence interval (95% CI) were also determined.ResultsThe RDW, platelet‐lymphocyte ratio (PLR), neutrophil‐lymphocyte ratio (NLR), and absolute lymphocyte count were significantly elevated in the invasive hydatidiform mole group compared with control group. The hemoglobin (Hb) concentration, mean red blood cell volume (MCV) and platelet count (PLT) were significantly lower in invasive hydatidiform mole group than control group. Grade III and above invasive hydatidiform mole patients had higher levels of RDW than grade I and II patients. Correlation analysis showed that RDW was negatively correlated with Hb, MCV, NLR, and neutrophil count, but positively correlated with PDW and different stages of invasive hydatidiform mole. The ROC curve showed that the AUC of the RDW was 0.660 (95% CI 0.581‐0.740; P < 0.01).ConclusionThis study reveals the potential value of RDW in invasive hydatidiform mole.

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Section: Discussionmentioning

confidence: 99%

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

Zhang

Xie

Zhan

2019

Clinical Laboratory Analysis

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“…Patients with urothelial carcinoma of the bladder (UCB) have elevated RDW compared with healthy individuals, suggesting RDW could be used in the diagnosis of UCB . Elevated RDW also helps identify colorectal cancer, ovary cancer, and myelodysplastic syndromes …”

Section: Discussionmentioning

confidence: 99%

Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma

et al. 2019

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Red blood cell distribution width (RDW), which measures the range of variation of red blood cell volume, has been explored as a prognostic factor in multiple types of cancer. However, the role of RDW in mantle cell lymphoma (MCL), a rare type of non‐Hodgkin lymphoma with poor outcomes, remains to be determined. Therefore, we investigated the prognostic role of RDW in MCL. We found that 21 of 76 MCL patients (27.6%) had an abnormally elevated RDW (>15.7%). Abnormally elevated RDW was significantly associated with presence of B symptoms (P = 0.0020), elevated lactate dehydrogenase (LDH) (P = 0.0010), higher leukocyte count (P = 0.0345), higher simplified Mantle Cell International Prognostic Index (sMIPI) (P = 0.0194), and lower level of hemoglobin (Hb) (P < 0.0001). It was marginally associated with increased C‐reactive protein (P = 0.0862). RDW was significantly correlated with Hb level (r2 = 0.42) and LDH level (r2 = 0.19). 15.8% was determined as the best cutoff of RDW in predicting the survival outcome by the X‐tile software. Survival analysis revealed that high RDW (>15.8%) predicted shorter progression‐free survival (PFS) (hazards ratio [HR]: 3.14; P = 0.0005) and shorter overall survival (OS) (HR: 4.04; P < 0.0001). High RDW independently predicted both shorter PFS (P = 0.0493) and OS (P = 0.0118). RDW also improved the prognostic stratification based on sMIPI. In conclusion, our study identified RDW as a novel prognostic factor of clinical feasibility in the prognostication of MCL.

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“…Red cell distribution width is known to be associated with systemic inflammation (15). Increase in RDW values have been suggested as a diagnostic and prognostic tool in colon cancer patients (16,17). Very recently, in a meta-analysis of 49 studies, elevated pretreatment RDW level was suggested as a negative predictor for cancer prognosis (18).…”

Section: Discussionmentioning

confidence: 99%

ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

Kasapoğlu¹,

Yozgat²,

Engın³

2019

Acta Oncol Tur.

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Bu çalışmada kolorektal kanserli hastalarda adjuvan kemoterapi tedavisi sonrasında hematolojik parametrelerdeki değişiklikleri değerlendirmeyi amaçladık. YÖNTEM ve GEREÇLER: Kolorektal kanser tanısı konan toplam 140 vakada değerlendirilmiş ve bu hastalardan 57'sine adjuvan kemoterapi verilmiştir. Adjuvan kemoterapi sonrası tam kan sayımı parametrelerindeki değişiklikler değerlendirildi. BULGULAR: Katılımcıların 67'si (% 47.9) kadın, 73'ü (% 52.1) erkek idi, yaş ortalamaları 62.13 ± 1.11 yıl idi. En sık görülen tümör yerleşimi rektumdu (% 45.7). Bu hastalardan 57'si adjuvan kemoterapi (% 40.7) aldı, en sık uygulanan kemoterapi rejimi Mayo rejimi (% 84.2) idi. Olgularımızın % 27.9'unda tanı anında metastaz vardı. Klinik takip sırasında hastaların% 10.7'sinde lokal nüks ve% 7.8'inde metastaz vardı. Hemoglobin (HGB) düzeyleri hem kan transfüzyonu yapılan hastalarda hem de yapılmayanlarda anlamlı bir düşüş gösterdi, ancak bu daha önce transfüzyonu olmayan hasta grubunda daha belirgindi (p = 0.002). Yardımcı kemoterapiyi takiben, beyaz kan hücresi değerleri (WBC), ortalama eritrosit hacimleri (MCV) ve trombosit (PLT) seviyelerinin, modifiye edici bileşenlerle (metastaz gelişimi, kemoterapi uygulama süresi, kan transfüzyonu) herhangi bir etkileşim olmadan önemli ölçüde azaldığı bulundu. (Sırasıyla p değerleri 0.002, 0.001 ve 0.001), ayrıca kırmızı hücre dağılım genişliği (RDW) önemli ölçüde artmıştır (p = 0.001). TARTIŞMA ve SONUÇ: Hgb, MCV, WBC ve trombosit seviyelerinde anlamlı bir azalma ve adjuvan kemoterapi sonrası RDW'de anlamlı bir artış vardı ve bu değişiklikler metastaz varlığından veya kemoterapi süresinden etkilenmedi. Kan parametrelerinde bu değişikliklerin hastaların prognozu ile ilişkisi ileriki çalışmalarda araştırılmalıdır. Anahtar Kelimeler: kolorektal kanser, beyaz kan hücresi değerleri, ortalama eritrosit hacmi, trombosit, kırmızı hücre dağılım genişliği ABSTRACT INTRODUCTION: In this study we aimed to evaluate the alterations in hematological parameters due to the adjuvant chemotherapy treatment in patients with colorectal cancer. METHODS: In a total of 140 cases diagnosed with colorectal cancer were evaluated and among those patients 57 received adjuvant chemotherapy. Alterations in complete blood count parameters after adjuvant chemotherapy were evaluated. RESULTS: Among participants, 67 (47.9%) were women and 73 (52.1%) were men with a mean age of 62.13 ± 1.11 years. The most common tumor localization was rectum (45.7%). Among these patients 57 received adjuvant chemotherapy (40.7%), the most frequently implemented chemotherapy regimen was Mayo regimen (84.2%). 27.9% of our cases had metastasis at the time of diagnosis. During clinical follow-up 10.7% of the patients had local relapse and 7.8% had metastasis. Hemoglobin (HGB) levels displayed a significant decrease both in patients who received blood transfusion or not, however this was more evident in the group of patients

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The value of red blood cell distribution width in diagnosis of patients with colorectal cancer

Cited by 38 publications

References 21 publications

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

The potential value of red blood cell distribution width in patients with invasive hydatidiform mole

Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma

ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

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