The value of real-time ultrasound elastography in chronic autoimmune thyroiditis

Menzilcioğlu, Mehmet Sait; Duymuş, Mahmut; Güngör, Gülay; Çitil, Serdal; Şahin, Tuna; Boysan, Serife Nur; Sarıca, Akif

doi:10.1259/bjr.20140604

Cited by 50 publications

(44 citation statements)

References 18 publications

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“…To the best of our knowledge, there are no studies in the literature about the use of ARFI in pediatric patients with Hashimoto thyroiditis. There were only a limited number of studies in adults, and only a few of these were performed with ARFI elastography . In a study by Sporea et al, the mean SWV of the thyroid gland in patients with Hashimoto thyroiditis (2.43 ± 0.58 m/s) was found to be significantly higher than that in healthy participants (2.00 ± 0.40 m/s).…”

Section: Discussionmentioning

confidence: 99%

Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis

Yücel

Bilgici

Kara

et al. 2017

J of Ultrasound Medicine

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Section: Discussionmentioning

confidence: 99%

Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis

Yücel

Bilgici

Kara

et al. 2017

J of Ultrasound Medicine

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“…Only one study has evaluated the value of strain elastography for the differential diagnosis of SAT (29), and only one study has evaluated the value of strain elastography for differential diagnosis of HT (21).…”

Section: Discussionmentioning

confidence: 99%

“…In 2014, Menzincioglu et al showed that SR is higher in HT than in normal thyroid parenchyma via RTE (21). However, their study group was relatively small (only 31 patients with HT) and had limited value.…”

Section: Chronic Autoimmune Thyroiditismentioning

confidence: 99%

Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Korkmaz¹,

Baki²,

Köse³

et al. 2017

Iran J Radiol

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Objectives: The main purpose of the present study was to determine the efficacy of real-time elastography (RTE) and strain elastography (STE) in the diagnosis of different thyroid diseases. We also aimed to calculate the cut-off points for the differential diagnosis of subacute thyroiditis (SAT), Graves' disease (GD), and Hashimoto's thyroiditis (HT), which have a similar B-mode sonographic appearance. Patients and Methods: A total of 24 patients with GD (10.9%), 94 patients with HT (42.7%), 20 patients with SAT (9.1%), and 82 individuals with normal healthy thyroids (37.3%) were included. Grayscale ultrasound evaluation of thyroid glands was performed with standard transverse and longitudinal planes before sonoelastography. Results:The strain ratios (SRs) (mean ± standard deviation) of patients with GD, HT, and SAT, and the control group (CG) were 14.7 ± 14.8, 8.4 ± 9.6, 23.2 ± 10.8, and 1.37 ± 0.8, respectively. The cut-off points of strain elastography of the patients with GD, HT, and SAT to the CG were 2.69 (sensitivity 92%, specificity 90%, area under the curve (AUC) 0.983; 95% CI), 2.18 (sensitivity 100%, specificity 85%, AUC 0.898), and 5.54 (sensitivity 100%, specificity 100%, AUC 1.000; 95% CI), respectively. The cut-off point of the strain ratios (SR) of the total amount of patients with HT and GD to SAT was 14.79 (sensitivity 80%, specificity 85%, AUC 0.869; 95% CI). Conclusion: Statistically significant differences were noted in the SR values and elasticity scores of the three experimental groups, and the CG. The elasticity scores of the SAT and HT groups were not significantly different from those of the GD group. The diagnostic performance of strain ratio elastography (P < 0.0001) was higher than that of real time elastography (P < 0.001). In terms of differentiating diagnosis, ES could differentiate SAT from HT, but it had no value in differentiating GD from HT and SAT. We also found statistically significant SRs for the differential diagnosis of SAT from GD and HT. Strain elastography could be a useful method for the differential diagnosis of SAT from a healthy population or from other types of thyroiditis such as GD and HT.

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“…Elastography was recently demonstrated to be an invaluable diagnostic method in differentiating between various pathologies in 283 patients with Hashimoto's thyroiditis (16,25). A strain index ratio and cut-off value of the thyroid tissue was higher in patients with chronic autoimmune thyroiditis compared with the values in normal thyroid parenchyma in RTE, suggesting that these two diagnostic parameters may be helpful for diagnosis or follow-up of lymphoma and malign nodules (26). Furthermore, the diagnostic values of CEUS or RTE alone were previously assessed in the characterization of thyroid nodules (16).…”

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced ultrasound and real-time elastography in the differential diagnosis of malignant and benign thyroid nodules

Xin

Liu

Jia

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The diagnostic value of contrast-enhanced ultrasound (CEUS) or real-time elastography (RTE) alone, as well as a combination of CEUS and RTE, in distinguishing benign from malignant thyroid nodules was investigated. Between August 2012 and June 2014, a total of 97 consecutive patients (50 male and 47 female patients; mean age, 48.6±12.4; age range, 27-70 years) with thyroid nodules referred for surgical treatment were examined by CEUS and RTE. The final diagnosis was obtained based on histological findings. Image analysis of the CEUS and RTE scans was performed. Considering the postoperative pathological results as the golden standard, a receiver operating characteristic (ROC) curve was constructed. Subsequently, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CEUS alone, RTE alone and CEUS + RTE combination were calculated. Pathological examination showed 66 papillary carcinomas and 43 benign lesions, including 21 adenomas and 22 nodular goiters. The sensitivity, specificity, PPV, NPV and accuracy of CEUS were 81.82, 90.70, 93.10, 90.70 and 85.32%, respectively. In the case of RTE, the sensitivity, specificity, PPV, NPV and accuracy were 80.30, 88.37, 91.38, 88.37 and 83.49%, respectively. Furthermore, the combination of CEUS + RTE had a sensitivity of 95.45%, specificity of 95.35%, PPV of 96.92%, NPV of 95.35% and accuracy of 95.41%. Therefore, the CEUS + RTE combination showed a significantly higher sensitivity and specificity compared with CEUS or RTE alone (all P<0.05). Based on ROC analysis, the area under the curve (AUC) for CEUS, RTE and CEUS + RTE combination was 0.883, 0.863 and 0.959, respectively. The AUC of RTE alone was significantly lower compared with that of the CEUS + RTE combination. In conclusion, our results demonstrate that CEUS + RTE combination significantly increases the diagnostic performance for differential diagnosis of malignant and benign thyroid nodules compared with CEUS or RTE alone.

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The value of real-time ultrasound elastography in chronic autoimmune thyroiditis

Cited by 50 publications

References 18 publications

Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis

Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis

Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Contrast-enhanced ultrasound and real-time elastography in the differential diagnosis of malignant and benign thyroid nodules

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