The Value of PSA, Free-to-total PSA Ratio and PSA Density in the Prediction of Pathologic Stage for Clinically Localized Prostate Cancer

Aslan, Güven; İrer, Bora; Kefi, Aykut; Çelebi, İlhan; Yörükoğlu, Kutsal; Esen, Adil

doi:10.1007/s11255-005-0921-x

Cited by 14 publications

(9 citation statements)

References 25 publications

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“…Although the Prostate-Specific Antigen (PSA) is a very good biomarker for prostate cancer, attempts to discriminate prostate cancer patients from a control group using the dataset reported by Petricoin et al [280] show that PSA correctly classifies only 62% of cancer patients. Similar results have been reported by other authors [281]. An explanation for this fact is that diseases are multi-causal phenomena so we should expect that the use of more than one biomarker may improve diagnostics.…”

Section: Graphs and Cis For Blood Proteome And/ Or Single Protein Massupporting

confidence: 89%

Proteomics, networks and connectivity indices

et al. 2008

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Describing the connectivity of chemical and/or biological systems using networks is a straight gate for the introduction of mathematical tools in proteomics. Networks, in some cases even very large ones, are simple objects that are composed at least by nodes and edges. The nodes represent the parts of the system and the edges geometric and/or functional relationships between parts. In proteomics, amino acids, proteins, electrophoresis spots, polypeptidic fragments, or more complex objects can play the role of nodes. All of these networks can be numerically described using the so-called Connectivity Indices (CIs). The transformation of graphs (a picture) into CIs (numbers) facilitates the manipulation of information and the search for structure-function relationships in Proteomics. In this work, we review and comment on the challenges and new trends in the definition and applications of CIs in Proteomics. Emphasis is placed on 1-D-CIs for DNA and protein sequences, 2-D-CIs for RNA secondary structures, 3-D-topographic indices (TPGIs) for protein function annotation without alignment, 2-D-CIs and 3-D-TPGIs for the study of drug-protein or drug-RNA quantitative structure-binding relationships, and pseudo 3-D-CIs for protein surface molecular recognition. We also focus on CIs to describe Protein Interaction Networks or RNA co-expression networks. 2-D-CIs for patient blood proteome 2-DE maps or mass spectra are also covered.

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Section: Graphs and Cis For Blood Proteome And/ Or Single Protein Massupporting

confidence: 89%

Proteomics, networks and connectivity indices

et al. 2008

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“…Tosoian ve ark. (13) aktif izlem grubundaki hastalardan kontrol biyopsisinde derece progresyonu saptanıp radikal prostatektomi uygulananların %23'ünde olumsuz patolojik bulgular nedeniyle cerrahiden sonraki 10 yıl içinde hastalıksız kalma şansının %75'ten az olduğu bildirilmiştir (13 (16,18,20,21,22,23,24,25,26,27 …”

Section: Discussionunclassified

Role of Prostate Specific Antigen Density for the Prediction of Radical Therapy Requirement in Localized Prostate Cancer

Bozkurt¹,

Çömez²,

Gürboğa³

et al. 2016

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“…Lam et al showed that PSAD at cut-off value of 0.15 ng/mL/mL spread 50% of men from undergoing unnecessary biopsies ( 11 ). In addition, some investigators have shown that PSAD is more specific compared to free to total PSA ratio especially when serum PSA level is at lower range ( 12 - 14 ). In our study, TZPSAD was found to be even more specific compared to PSAD and spread more patients from undergoing unnecessary biopsies.…”

Section: Discussionmentioning

confidence: 99%

Transition Zone Prostate Specific Antigen Density Improves Prostate Cancer Detection in Iranian Men

et al. 2015

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Background:Prostate specific antigen (PSA) as a tumor marker has extensively changed the diagnosis of prostate cancer (PCa). With the advent of PSA, the majority of patients are diagnosed with nonpalpable early stage PCa. However, PSA lacks specificity and many patients undergo unnecessary biopsies due to an elevated serum PSA level.Objectives:This study aimed to assess the sensitivity and specificity of transition zone PSA density (TZPSAD) in detection of PCa.Patients and Methods:This study was performed on 1712 men underwent trans-rectal ultrasound guided prostate biopsy in our institution between March 2008 and March 2013. A total of 1120 men with PSA < 20 ng/mL and normal digital rectal exam were selected for evaluation. Transition zone PSA density was calculated in all patients and the receiver operating characteristic (ROC) curve was used to analyze the accuracy of TZPSAD for the diagnosis of PCa.Results:Among 1120 men who were eligible for enrolment, prostate cancer was detected in 265 patients. Mean serum PSA levels were 9.7 ± 4.3 ng/mL and 8.5 ± 3.7 ng/mL in patients with and without PCa, respectively (P < 0.001). Mean value for TZPSAD was 1.18 ± 1.19 ng/mL/mL in patients with PCa, whereas it was 0.55 ± 0.84 ng/mL in men without cancer (P < 0.001). Optimal cut-off value for TZPSAD was 0.32 ng/mL. At this cut-off value, the sensitivity and specificity values for TZPSAD were 85% and 45%, respectively. Applying the TZPSAD for PCa screening decreased 50% of unnecessary biopsies.Conclusions:Using TZPSAD as an adjunct to PSA may improve the specificity of PSA in the diagnosis of PCa and decrease the number of unnecessary prostatic biopsies in Iranian men with serum PSA level < 20 ng/mL.

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The Value of PSA, Free-to-total PSA Ratio and PSA Density in the Prediction of Pathologic Stage for Clinically Localized Prostate Cancer

Abstract: While PSAD is more helpful than PSA and free/total PSA ratio for prediction of organ-confined disease, none of these parameters are significant predictor of pathologic stage for clinically localized prostate cancer.

Cited by 14 publications

References 25 publications

Proteomics, networks and connectivity indices

Proteomics, networks and connectivity indices

Role of Prostate Specific Antigen Density for the Prediction of Radical Therapy Requirement in Localized Prostate Cancer

Transition Zone Prostate Specific Antigen Density Improves Prostate Cancer Detection in Iranian Men

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