The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis

Saeed, Kordo; Ahmad, Nusreen; Dryden, Matthew

doi:10.1586/14737159.2014.864238

Cited by 24 publications

(19 citation statements)

References 35 publications

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“…However, in some cases, there are difficulties in using these markers as indicators of diagnosis and treatment due to their low sensitivity and specificity5. A recent study reported the value of procalcitonin in bullous impetigo, staphylococcal scaled skin syndrome, localized skin infection, diabetic foot infection, septic arthritis and osteomyelitis67. In addition, procalcitonin may be a useful tool for the initial diagnosis and monitoring of cutaneous infection or cutaneous soft tissue infection8.…”

Section: Introductionmentioning

confidence: 99%

Serum Procalcitonin Level Reflects the Severity of Cellulitis

2016

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BackgroundCellulitis is a common bacterial infection of the superficial skin. Procalcitonin is one of the precursor proteins of calcitonin, its levels are elevated in bacterial infection, and it has been established as a diagnostic marker for severe bacterial infections.ObjectiveThis study evaluated the clinical usefulness of procalcitonin for predicting disease severity and prognosis of cellulitis.MethodsWe reviewed the medical records of 160 patients diagnosed with cellulitis in the past 3 years. Body temperature, procalcitonin, white blood cell (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured on their first day of admission. The associations of procalcitonin, WBC, ESR, and CRP with the body temperature and the number of hospitalized days were assessed.ResultsProcalcitonin, WBC, and CRP showed a positive correlation with body temperature. In addition, procalcitonin, WBC, ESR, and CRP showed a positive correlation with number of hospitalized days (p<0.05).ConclusionIn patients diagnosed with cellulitis, proclacitonin was a helpful parameter to indicate the severity of disease and also a useful predictor of prognosis.

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Section: Introductionmentioning

confidence: 99%

Serum Procalcitonin Level Reflects the Severity of Cellulitis

2016

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“…A very recent study looked at the value of PCT and interleukin‐6 in patients with bullous impetigo and staphylococcal scalded skin syndrome . Finally, a review paper discussed the value of PCT in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis …”

Section: Introductionmentioning

confidence: 99%

“…23 Finally, a review paper discussed the value of PCT in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis. 24 The aim of our study was to investigate the diagnostic value of PCT levels as compared with CRP levels and WBC counts in a consecutive at-risk population of patients presenting with either erysipelas or DVT of the lower limb to the ED of a tertiary care hospital in Switzerland.…”

Section: Introductionmentioning

confidence: 99%

Use of procalcitonin, C‐reactive protein and white blood cell count to distinguish between lower limb erysipelas and deep vein thrombosis in the emergency department: A prospective observational study

Rast

Knobel

Faessler

et al. 2015

The Journal of Dermatology

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Early differentiation of erysipelas from deep vein thrombosis (DVT) based solely on clinical signs and symptoms is challenging. There is a lack of data regarding the usefulness of the inflammatory biomarkers procalcitonin (PCT), C-reactive protein (CRP) and white blood cell (WBC) count in the diagnosis of localized cutaneous infections. Herein, we investigated the diagnostic value of inflammatory markers in a prospective at-risk patient population. This is an observational quality control study including consecutive patients presenting with a final diagnosis of either erysipelas or DVT. The association of PCT (lg/L) and CRP (mg/L) levels and WBC counts (g/L) with the primary outcome was assessed using logistic regression models with area under the receiver-operator curve. Forty-eight patients (erysipelas, n = 31; DVT, n = 17) were included. Compared with patients with DVT, those with erysipelas had significantly higher PCT concentrations. No significant differences in CRP concentrations and WBC counts were found between the two groups. At a PCT threshold of 0.1 lg/L or more, specificity and positive predictive values (PPV) for erysipelas were 82.4% and 85.7%, respectively, and increased to 100% and 100% at a threshold of more than 0.25 lg/L. Levels of PCT also correlated with the severity of erysipelas, with a stepwise increase according to systemic inflammatory response syndrome criteria. We found a high discriminatory value of PCT for differentiation between erysipelas and DVT, in contrast to other commonly used inflammatory biomarkers. Whether the use of PCT levels for early differentiation of erysipelas from DVT reduces unnecessary antibiotic exposure needs to be assessed in an interventional trial.

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“…The use of serum procalcitonin has been suggested as a valuable marker for the severity and mortality in sepsis 10,11 and possibly acute osteomyelitis. 15 Diagnostic imaging tools to assess bone infection include MRI and bone scans. 13 Other investigators have demonstrated the superiority of CRP over procalcitonin for detecting infection in deep orthopaedic implants.…”

Section: Chronic Wounds With Exposed Implantsmentioning

confidence: 99%

Soft-tissue coverage of exposed orthopaedic trauma implants

Kovach

2015

Current Orthopaedic Practice

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Reconstitution of the soft-tissue envelop to provide stable, durable coverage of orthopaedic implants is an important component in the overall management plan of the orthopaedic trauma patient. When planning soft-tissue coverage, important considerations include the temporal nature of the exposed implant, anatomic region, soft-tissue needs, functional expectations, phase of bone healing, infection, bone reconstruction needs. Patient evaluation and work-up must be thorough, with personal inspection of wounds by the reconstructive surgeon. To maximize patient outcomes, a well-coordinated multidisciplinary team approach is mandatory.

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The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis

Cited by 24 publications

References 35 publications

Serum Procalcitonin Level Reflects the Severity of Cellulitis

Serum Procalcitonin Level Reflects the Severity of Cellulitis

Use of procalcitonin, C‐reactive protein and white blood cell count to distinguish between lower limb erysipelas and deep vein thrombosis in the emergency department: A prospective observational study

Soft-tissue coverage of exposed orthopaedic trauma implants

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