The value of pretreatment glucose-to-lymphocyte ratio for predicting survival of metastatic gastric cancer

Hannarici, Zekeriya; Yılmaz, Ali; Buyukbayram, Mehmet Emin; Turhan, Aykut; Çağlar, Alperen Akansel; Bilici, Mehmet; Tekin, Salim Başol

doi:10.2217/fon-2022-0579

Cited by 2 publications

(4 citation statements)

References 39 publications

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“…The Globulin-lymphocyte ratio (GLR) has been associated with poor prognosis in various cancer types including lung, breast, stomach, liver, esophageal, kidney, colorectal cancers, and melanoma, as evidenced by a study encompassing 2172 patients. 10 Similarly, Hannarici et al 13 for metastatic stomach cancer and Yang et al 12 for colorectal cancers have shown GLR to be an independent prognostic marker.…”

Section: Discussionmentioning

confidence: 97%

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Effect of glucose lymphocyte ratio on prognosis in patients operated with the diagnosis of pancreatic adenocarcinoma

Sezikli,

Tutan,

Yüksek

et al. 2024

JOCS

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Aims: Pancreatic adenocarcinoma is one of the most aggressive cancers, and predicting prognosis and survival clinically is challenging. Prognostic markers, easily accessible and routinely evaluated in diagnostic tests, are frequently seen in the literature for survival prediction. So far, the glucose lymphocyte ratio (GLR) has emerged as an indicator that can assess both metabolic dysregulation and immune response. In this study, the aim was to assess the impact of GLR on prognosis and survival by following patients diagnosed with pancreatic adenocarcinoma who underwent surgery. Methods: Between January 1, 2016, and April 31, 2021, a totalof 58 patients who underwent Whipple procedure due to pancreatic adenocarcinoma at the Department of General Surgery, Hitit University, were included in the study. Demographic characteristics, tumor features, laboratory results, and survival durations of the patients were collected. GLR was determined as a mortality predictor, and estimated survival times associated with GLR were determined using Kaplan-Meier Survival analysis. The optimal GLR value was determined through ROC analysis. Results: During the postoperative period, the average follow-up time for patients was 11.39 months, with the longest follow-up time being 48 months. During this period, 43 patients (74.14%) were deceased, while 15 patients (25.86%) survived. The mean age and ASA scores of deceased patients were significantly higher compared to survivors (p<0.001 and p<0.001, respectively). Glucose levels were significantly higher in the mortality group compared to the survival group (p=0.008). GLR was notably higher in the mortality group (p=0.170; p=0.703; p=0.429; and p=0.031). The GLR value that best distinguished the two groups was found to be 94.6387 with 93.3% specificity and 95.8% positive predictive value. Crossing this threshold increased the mortality risk approximately 4.27 times within one year and increased the overall mortality risk by approximately 15 times (p=0.014 and p=0.002). The estimated life expectancy for patients below the threshold value was calculated to be an average of 20.996 months, whereas for patients above the threshold value, this expectation was calculated to be an average of 4.427 months (p<0.001). Conclusion: We believe that GLR may be helpful in predicting one-year survival and determining overall survival duration in patients undergoing surgery for pancreatic adenocarcinoma.

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Section: Discussionmentioning

confidence: 97%

“…However, there is limited research on the use of GLR as a prognostic marker in pancreatic cancer. [10][11][12][13] This study aimed to investigate the impact of GLR on prognosis and survival in patients undergoing surgery for pancreatic adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

Effect of glucose lymphocyte ratio on prognosis in patients operated with the diagnosis of pancreatic adenocarcinoma

Sezikli,

Tutan,

Yüksek

et al. 2024

JOCS

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“…Yılmaz A and colleagues ( 17 ) have discovered that GLR prior to sorafenib therapy serves as a novel prognostic biomarker, accurately predicting survival rates in patients diagnosed with advanced hepatocellular carcinoma. The prognostic significance of the GLR has been demonstrated in studies involving metastatic gastric cancer (mGC) and metastatic breast cancer (MBC) patients receiving Cdk 4/6 inhibitors ( 16 ). Additionally, in patients with type 2 diabetes and MBC, the preoperative hyperglycemia to lymphocyte ratio was found to be an independent predictor of preoperative central lymph node metastasis ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

“…The elevated GLR may serve as an indicator of the combined impact of hyperglycemia and immune dysfunction in critically ill individuals. Current clinical studies suggest that elevated GLR is an important predictor of acute mortality and prognosis in patients with gastric cancer ( 16 ),hepatocellular carcinoma ( 17 ), breast cancer, thyroid cancer, rectal cancer ( 18 ), acute respiratory distress syndrome and acute exacerbation of chronic obstructive pulmonary disease ( 11 ).Therefore, it has important clinical significance in terms of malignant tumor disease burden and respiratory disease burden. The aim of this study was to evaluate the correlation between GLR at admission and prognosis of hospitalization in patients with non-traumatic cerebral hemorrhage.…”

Section: Introductionmentioning

confidence: 99%

Association between high serum blood glucose lymphocyte ratio and all-cause mortality in non-traumatic cerebral hemorrhage: a retrospective analysis of the MIMIC-IV database

Yang,

Liu,

Wang

et al. 2023

Front. Endocrinol.

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BackgroundThis study aimed to evaluate the association between the glucose-to-lymphocyte ratio (GLR) and all-cause mortality in intensive care unit (ICU) patients with Non-traumatic cerebral hemorrhage.MethodsThis is a retrospective cohort study. Baseline data and in-hospital prognosis from patients with non-traumatic cerebral hemorrhage admitted to the intensive care unit. Multivariate COX regression analysis was applied and adjusted hazard ratios (HR) and 95% predictive values with confidence intervals (CI) were calculated. Survival curves for the two groups of cases were plotted using K-M curves, and subgroup analyses were performed in one step. Using restricted cubic spline curves, we analyzed the potential linear relationship between GLR and outcome indicators.ResultsIn the Medical Information Mart for Intensive Care IV (MIMIC-IV database), we extracted 3,783 patients with nontraumatic intracerebral hemorrhage, and 1,806 patients were finally enrolled in the study after exclusion of missing values and patients with a short hospital stay. The overall ICU mortality rate was 8.2% (148/1806) and the in-hospital mortality rate was 12.5% (225/1806). The use of curve fitting yielded a significant linear relationship between GLR and both ICU mortality and in-hospital mortality. It also suggested a reference point at GLR=3.9. These patients were categorized into high and low subgroups based on the median value of their GLR (GLR = 3.9). Model comparisons based on multivariate COX regression analysis showed that in-hospital mortality was higher in the high GLR group after adjusting for all confounders (HR = 1.31, 95% CI: 1.04-1.47), while the ICU mortality in the high GLR group was (HR = 1.73, 95% CI: 1.18-2.52). Stratified analyses based on age, gender, race, GCS, BMI, and disease type showed stable correlations between the high GLR group and in-hospital and ICU mortality.ConclusionBased on our retrospective analysis, it is known that as the GLR increased, the in-hospital mortality rate and ICU mortality rate of patients with nontraumatic cerebral hemorrhage also increased progressively in the United States in a clear linear relationship. However, further studies are needed to confirm these findings.

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The value of pretreatment glucose-to-lymphocyte ratio for predicting survival of metastatic gastric cancer

Cited by 2 publications

References 39 publications

Effect of glucose lymphocyte ratio on prognosis in patients operated with the diagnosis of pancreatic adenocarcinoma

Effect of glucose lymphocyte ratio on prognosis in patients operated with the diagnosis of pancreatic adenocarcinoma

Association between high serum blood glucose lymphocyte ratio and all-cause mortality in non-traumatic cerebral hemorrhage: a retrospective analysis of the MIMIC-IV database

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