The Value of Partial HPV Genotyping After Conization of Cervical Dysplasias

Friebe, Kristin; Klapdor, Rüdiger; Hillemanns, Peter; Jentschke, Matthias

doi:10.1055/s-0043-115395

Cited by 11 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the past 15 years, however, the incidence of cervical cancer has been stagnating at a low Diagnostics 2022, 12, 1748 2 of 13 level, despite advances in diagnosis and therapy [1][2][3]. Invasive cervical cancer is caused by a persistent infection with human papillomavirus (HPV) [4][5][6]. HPV is a biological carcinogen, and high-risk HPV (hrHPV) types are detected in up to 99.7% of cervical cancers [4,7].…”

Section: Introductionmentioning

confidence: 99%

Cytology and High-Risk Human Papillomavirus Test for Cervical Cancer Screening Assessment

et al. 2022

View full text Add to dashboard Cite

Background: A new nationwide screening strategy was implemented in Germany in January 2020. No data are available for women referred to certified dysplasia units for secondary clarification after primary diagnosis by a local physician. We therefore investigated combined testing with Papanicolaou smears and high-risk human papillomavirus (hrHPV) and compared the data with the final histological findings. Methods: Between January 2015 and October 2020, all referred women who underwent colposcopy of the uterine cervix in our certified dysplasia unit were included. Cytology findings were classified using the Munich III nomenclature. Results: A total of 3588 colposcopies were performed in 3118 women, along with Pap smear and hrHPV co-testing, followed by histology. Women with Pap II-p (ASC-US) and a positive hrHPV co-test had a 22.4% risk for cervical intraepithelial neoplasia (CIN) 3/high-grade squamous intraepithelial lesion (HSIL). The risk of CIN 3/HSIL was 83.8% in women with Pap IVa-p (HSIL) and a positive hrHPV co-test. A positive hrHPV co-test increased the risk for HSIL+ (OR 5.942; 95% CI, 4.617 to 7.649; p < 0.001) as compared to a negative hrHPV co-test. Conclusions: The accuracy of Pap smears is comparable with the screening results. A positive hrHPV test increases the risk for HSIL+ fivefold. Colposcopy is necessary to diagnose HSIL+ correctly.

show abstract

Section: Introductionmentioning

confidence: 99%

Cytology and High-Risk Human Papillomavirus Test for Cervical Cancer Screening Assessment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Kang et al [25] reported that HPV 16/18 was detected in a group that underwent hysterectomy after a loop electrosurgical excision procedure. Moreover, testing for postoperative HR-HPV genotypes can predict recurrence and additional surgery [19,26]. The present study showed that the HR of additional surgery was characterized by not only the surgical margin status and positive preoperative HR-HPV but also the same persistent HR-HPV genotype around conization, especially HPV 16/18.…”

Section: Discussionmentioning

confidence: 55%

Prognostic Value of Human Papillomavirus Genotyping before and after Cervical Conization for Squamous Intraepithelial Lesion

et al. 2022

View full text Add to dashboard Cite

Introduction: We previously reported that preoperative human papillomavirus (HPV) type 16/18 positivity and postoperative high-risk (HR)-HPV test positivity are associated with abnormal postoperative cytology. In this study, we further examined whether preoperative and postoperative HR-HPV genotyping could predict cytological abnormalities and the risk of additional surgery. Methods: Patients who underwent cervical conization at our hospital between July 2009 and June 2018 were enrolled. HPV genotyping was performed preoperatively for all patients with HPV-positive. The association among preoperative and postoperative HR-HPV genotyping results, the cumulative risk of cytological abnormalities, and additional surgery were evaluated. The endpoint approach was used to investigate the cumulative incidence of additional surgery owing to cytological abnormalities, such as low-grade squamous intraepithelial lesion positivity and recurrence 2 years after cervical conization. Results: Positive and negative histological margins were observed in 21 and 287 of 308 cases, respectively. The cumulative incidence of abnormal cytology and additional surgery was significantly higher in margin-positive cases than that in margin-negative cases. Examination established according to the margin status demonstrated that the postoperative HR-HPV-positive group had a significantly worse prognosis than the HR-HPV-negative group. Additionally, 32 cases, wherein the same genotype detected before and after surgery, demonstrated significantly unfavorable outcomes. Fifteen patients with persistent HPV 16/18 had the worst prognosis than the other types. Conclusion: Preoperative and postoperative HR-HPV genotype tests were used to predict the cumulative incidence of abnormal cytology and additional surgery. Particularly, patients with suspected persistent HPV type 16/18 infection are at a high recurrence risk.

show abstract

“…We identified 7 eligible studies [ 8 , 9 , 17 , 19 , 20 , 23 , 32 ] including 1790 CIN patients after surgery to investigate the relationship between HPV types and persistent HPV infection and nonpersistent HPV infection. Our results revealed that there was a positive effect on persistent HPV infection between HPV 16 and other types of HPV.…”

Section: Resultsmentioning

confidence: 99%

Persistent HPV infection after conization of cervical intraepithelial neoplasia—— a systematic review and meta-analysis

Zhang

Ni²,

Wei

et al. 2023

BMC Women's Health

View full text Add to dashboard Cite

Objective To systematically evaluate several factors of persistent human papillomavirus (HPV) infection following conization in patients with cervical intraepithelial neoplasia (CIN). Methods PubMed, EMBASE and the Cochrane Library were searched from January 1, 1998 to September 10, 2021. Random-effects models for meta-analyses were used and pooled relative risks with 95% confidence intervals were reported. Literature screening, data extraction, and assessment of the risk of bias in the included studies were conducted independently by two researchers. Data analysis was performed with Stata software, version 12.0. Results A total of 28 studies were included in this study. Meta-analysis revealed that surgical margin and residual disease were positively correlated with persistent HPV infection after conization. Compared with patients infected with other types of HPV, CIN patients with HPV 16 had a higher persistent infection rate (OR = 1.967, 95% CI (1.232–3.140), P < 0.05). Conclusions CIN patients who are postmenopausal, have positive surgical margins and residual lesions, and are positive for HPV 16 are prone to persistent HPV infection after conization.

show abstract

The Value of Partial HPV Genotyping After Conization of Cervical Dysplasias

Cited by 11 publications

References 29 publications

Cytology and High-Risk Human Papillomavirus Test for Cervical Cancer Screening Assessment

Cytology and High-Risk Human Papillomavirus Test for Cervical Cancer Screening Assessment

Prognostic Value of Human Papillomavirus Genotyping before and after Cervical Conization for Squamous Intraepithelial Lesion

Persistent HPV infection after conization of cervical intraepithelial neoplasia—— a systematic review and meta-analysis

Contact Info

Product

Resources

About