The value of narrow band imaging for early detection of laryngeal cancer

Abstract

We evaluate the value of laryngoscopy using narrow band imaging (NBI) system in the diagnosis of precancerous and cancerous laryngeal lesions. Thirty-four patients were suspected of having a total of 35 precancerous or cancerous laryngeal lesions among patients receiving conventional white-light laryngoscopy. All 34 patients underwent laryngoscopy with NBI system to determine whether those lesions were malignant before biopsy procedure. The diagnostic criteria of malignancy by NBI view was the presence of demarcated brownish area with scattered brown spots in the lesion. Histopathologic results were retrospectively compared with results of determination of malignancy made by NBI view. Of the 23 lesions histopathologically proved to be malignancies, 21 lesions were classified as malignant by NBI view. Sensitivity and specificity for the diagnosis of malignancy by means of NBI view compared with histopathologic results were 91.3% for sensitivity and 91.6% for specificity. NBI endoscopy seems to be a very promising diagnostic tool in the diagnosis of laryngeal malignant disease.

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

“…protuberant or ulcerative lesions covered with necrotic tissue, or leukoplakia of unknown type); or (3) benign (types I to IV) (135). In the literature, there exist only a few publications on the exclusive use of NBI in laryngology (135)(136)(137)(138)(139)(140)(141)(142). However, several studies assessed the value of NBI in the head and neck also including the larynx (132,137,(143)(144)(145)(146)(147)(148).…”

“…The introduction of narrow band imaging (NBI, Olympus Medical System Corporation, Tokyo, Japan), already proven to be an useful screening method in other medical fields, has recently shown its potential in identifying carcinomas at an early stage in head and neck mucosal sites (136,139,239,240). The NBI filter sets (415 nm, which is the hemoglobin absorption band, and 540 nm) are selected to obtain fine images of microvascular structures of different types tissue, which are necessary for diagnosing a tumor at early stage.…”

Narrow Band Imaging (NBI) — Endoscopic Method for Detection of Head and Neck Cancer

“…Typical suspect finding in NBI image is defined as well demarcated brownish area, exhibiting scattered brown dots within this area on close view [11] (Figure 3). Brown dots are caused by expansion of IPCL, which is due to neoangiogenesis in tumour growth.…”

“…Improved contrast between mucosal epithelium and blood vessels helps to visualize mucosal lesions few millimetres in Endoscopydiameter ( Figure 6). The sensitivity and specificity of flexible NBI endoscopy in follow-up of head and neck SCC patients were reported 91,3 -100% and 91,6 -98% respectively [17,11].…”

“…verrucous carcinomas [24]. Nevertheless, most false positive results of NBI endoscopy were reported in case of laryngeal papillomatosis [11]. In these cases, demarcated lesions with scattered brown dots are often found.…”