The value of narrow band imaging in diagnosis of head and neck cancer: a meta-analysis

Zhou, Hui; Zhang, Jing; Guo, Linghong; Nie, Ji; Zhu, Chenjing; Ma, Xuelei

doi:10.1038/s41598-017-19069-0

Cited by 49 publications

(37 citation statements)

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“…In 2018, Zhou et al [34] published a meta-analysis assessing the value of NBI endoscopy in the diagnosis of cancerous lesions of the head and neck area. Sensitivity is 88.5%, specificity 95.6%, area under the curve AUC 96.94%.…”

Section: Methodsmentioning

confidence: 99%

Comparative evaluation of the diagnostic value of biopsy and NBI endoscopy in patients with cancer of the hypopharynx and larynx

Wacławek

Miłoński

Olszewski³

2019

Otolaryngol Pol

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INTRODUCTION: Novel endoscopic technique - Narrow Band Imaging (NBI) seems to be a promising method for an early detection of neoplastic lesions of the upper aerodigestive tract. Compared to white light endoscopy, NBI improves the visualisation of the mucosal and submucosal microvascular patterns of observed pathologies. The aim of the study was to evaluate the diagnostic value of biopsy and NBI in patients with cancer of the larynx and hypopharynx. MATERIAL AND METHODS: The study was conducted in 100 adult subjects hospitalized in the Clinic of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics of Military Medical Academy University Teaching Hospital in Lodz, who were planned for surgical procedures for excision or surgical biopsy of pathological lesions of the hypopharynx or larynx. The following examinations were performed: subjective and objective, otorhinolaryngological, NBI endoscopy and histopathological assessment of suspicious lesions. The microvascular pattern of observed lesions was assessed according to the Ni scale criteria. The next stage of the study was to compare the endoscopic examination results (type of vascular pattern according to the Ni scale) with the histopathological result. The obtained results were subjected to statistical analysis. RESULTS: The sensitivity of NBI endoscopy in detection of malignant neoplasms in patients with hypopharynx and larynx lesions is 90.48%, specificity 91.14%, positive predictive value 73.08%, negative predictive value 97.30%. CONCLUSIONS: NBI endoscopy is a modern imaging method, increasing the diagnostic potential of endoscopy in the early detection of malignant lesions within the hypopharynx and larynx.

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Section: Methodsmentioning

confidence: 99%

Comparative evaluation of the diagnostic value of biopsy and NBI endoscopy in patients with cancer of the hypopharynx and larynx

Wacławek

Miłoński

Olszewski³

2019

Otolaryngol Pol

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“…Furthermore, bladder cancer shows relatively higher Prx II expression in early stages and it reduces significantly with bladder cancer progression to malignant stages. Expression of Prx II in lymphoma further depends on the lymphoma cell type because, Prx II is silenced in Hodgkin lymphoma but not in Burkitt lymphoma which belongs to non-Hodgkin lymphoma [ 114 , 115 ].…”

Section: Discussionmentioning

confidence: 99%

“…Head and neck cancers consist of a wide range of cancers including oral cavity and oropharyngeal cancers, nasopharyngeal cancers and laryngeal and hypopharyngeal cancers [ 114 ]. Prx II has been reported to express highly in those cancers and protect head and neck cancer cells from oxidative stress and radiation-induced cellular damages.…”

Section: Association Of Prx II With Stemness Properties In Cancermentioning

confidence: 99%

Peroxiredoxin II Regulates Cancer Stem Cells and Stemness-Associated Properties of Cancers

Chandimali

Jeong

Kwon

2018

Cancers

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Cancer stem cells (CSCs) represent a sub-population of cancer cells with the ability to regulate stemness-associated properties which are specifically responsible for unlimited growth of cancers, generation of diverse cancer cells in differentiated state and resistance to existing chemotherapy and radiotherapy. Even though, current therapies destroy majority of cancer cells, it is believed to leave CSCs without eradicating which may be the conceptualization for chemoresistance and radio-resistance. Reactive oxygen species (ROS) maintain stem cells and regulate the stemness-associated properties of cancers. Beyond the maximum limit, ROS can damage cellular functions of cancers by subjecting them to oxidative stress. Thus, maintenance of ROS level plays an important role in cancers to regulate stemness-associated properties. Peroxiredoxin II (Prx II) is a member of peroxiredoxin antioxidant enzyme family which considers as a regulator of ROS in cellular environments by modulating redox status to maintain CSC phenotype and stemness properties. Prx II has cell type-dependent expression in various types of cancer cells and overexpression or silenced expression of Prx II in cancers is associated with stem cell phenotype and stemness-associated properties via activation or deactivation of various signaling pathways. In this review, we summarized available studies on Prx II expression in cancers and the mechanisms by which Prx II takes parts to regulate CSCs and stemness-associated properties. We further discussed the potential therapeutic effects of altering Prx II expression in cancers for better anticancer strategies by sensitizing cancer cells and stem cells to oxidative stress and inhibiting stemness-associated properties.

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“…Head and neck cancer include oral cavity and oropharyngeal cancers, nasopharyngeal cancers, and laryngeal and hypo-pharyngeal cancers. 1 It is estimated that by the end of year 2020 over 10 million people worldwide would die of cancer every year and about 66% of these would be from developing world like India (WHO-UCC 2003). 2 Globocan 2012, states incidence of head and neck cancer every year is about 683235/1000, 000, the mortality is 375664/1000,000.…”

Section: Introductionmentioning

confidence: 99%

Demographics and targeted biopsy with NBI in head and neck mucosal lesions

Bhandari

Sachdeva

2020

Int J Otorhinolaryngol Head Neck Surg

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Background: It is estimated that by the end of year 2020 over 10 million people worldwide would die of cancer every year and about 66% of these would be from developing world like India (WHO-UCC 2003). Our aim in present study was to evaluate the use of targeted biopsy of mucosal lesions of head and neck cancer using narrow band imaging technique, in order to yield more accurate specimen of lesion which will result in correct diagnosis of disease early and to study different demographics of patients.Methods: Patients lesions were examined under NBI endoscope, best site of biopsy were identified on the basis of increase vascularity, neo-angiogenesis and superficial capillary vessels. Biopsy were taken from this site and sent for histopathological examinations. Considering histopathological report as standard, results from NBI endoscopy were compared to the results of previous studies and conclusion was done. We also studied different demographics of these patients under site of lesion, age distribution, sex distribution, and locality, histopathology type. Results: Maximum lesions were found in oral cavity (56.33%). Malignancy was also more common in oral cavity (63.46%), mostly belong to squamous cell carcinoma on histopathology. Mean age of presentation of head and neck mucosal lesion was found to be 48 year and of malignant lesions is 54 years.Conclusions: We conclude that up to an extent with progression of age malignant lesions increase. Male to female ratio of mucosal lesions is 1.7:1 and of malignancy is 2.25:1. Narrow band imaging endoscopy helps us to identify best site of biopsy, helping in early diagnosis of disease and ultimately reducing morbidity and mortality of patient.

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The value of narrow band imaging in diagnosis of head and neck cancer: a meta-analysis

Cited by 49 publications

References 50 publications

Comparative evaluation of the diagnostic value of biopsy and NBI endoscopy in patients with cancer of the hypopharynx and larynx

Comparative evaluation of the diagnostic value of biopsy and NBI endoscopy in patients with cancer of the hypopharynx and larynx

Peroxiredoxin II Regulates Cancer Stem Cells and Stemness-Associated Properties of Cancers

Demographics and targeted biopsy with NBI in head and neck mucosal lesions

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