The value of molecular diagnostics in primary cutaneous B-cell lymphomas in the context of clinical findings, histology, and immunohistochemistry

Felcht, Moritz; Booken, Nina; Stroebel, Philipp; Goerdt, Sergij; Klemke, Claus‐Detlev

doi:10.1016/j.jaad.2009.12.062

Cited by 34 publications

(53 citation statements)

References 28 publications

(54 reference statements)

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“…Although MALT lymphoma is a B-cell lymphoma, it rarely accounts for MTX-LPD [6]. In the present case, we diagnosed MALT lymphoma on the basis of the histopathologic analysis, although immunoglobulin heavy chain gene rearrangement or flow cytometry is necessary to confirm the monoclonality of B cells in orbital LPDs [7]. On the other hand, the [8].…”

Section: Discussionmentioning

confidence: 93%

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

et al. 2016

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The patient was a 74-year-old Japanese woman with rheumatoid arthritis (RA) who developed generalized lymphadenopathy with elevated levels of lactase dehydrogenase (LD), and soluble IL-2 receptor (sIL-2R). She was found to be positive for anti-human T-cell leukemia virus type 1 (HTLV-1) antibodies. Her symptoms and laboratory abnormalities spontaneously regressed after the cessation of methotrexate (MTX), suggesting that she had an MTX-associated lymphoproliferative disorder; however, her lymphadenopathy appeared again approximately 14 months later with LD and sIL-2R elevation. A histopathological analysis and Southern blotting of a lymph node biopsy specimen for HTLV-1 provirus supported the diagnosis of adult T-cell leukemia/lymphoma (ATL) (lymphoma type). These data confirmed that an HTLV-1 positive RA patient may develop ATL.

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Section: Discussionmentioning

confidence: 93%

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

et al. 2016

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“…74 Clonal immunoglobulin gene rearrangements can be detected in more than 90% of cases. 75,76 PCFCL has an excellent prognosis with more than 95% 5-year survival. 73,77 Small, well-demarcated solitary lesions are treated with surgical excision or radiation therapy with 40-70% of patients having cutaneous relapses.…”

Section: Primary Cutaneous Follicle Center Lymphomamentioning

confidence: 99%

“…81,84,85 but clonality can usually be shown by PCR. 75,76 PCMZL is an indolent disease with a 5-year disease-specific survival of over 95%. 77 Staging procedures with whole body imaging are recommended to rule out cutaneous involvement by MZL at other sites.…”

Section: Primary Cutaneous Marginal Zone Lymphomamentioning

confidence: 99%

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

et al. 2014

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“…Even more helpful is testing of samples from more than 1 site. Several studies [59][60][61] have demonstrated that detecting the same clone from different sites, including a single skin and peripheral blood sample, increases the reliability of these tests. Therefore, when results are questionable, one can request retesting on a new sample for comparison of the possible clone.…”

Section: Use Of Clonality Studies In the Diagnosismentioning

confidence: 99%

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

Dewar¹,

Andea²,

Guitart³

et al. 2015

Archives of Pathology & Laboratory Medicine

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Context.-Primary cutaneous lymphoma is a common extranodal non-Hodgkin lymphoma. These lesions share common features with their nodal counterparts, but also have differences in morphology, unique clinical presentations, and immunohistochemical features.Objective. - Data Sources.-The WHO and EORTC classification publications and the relevant recent literature were used to compile appropriate and practical guidelines in this review.Conclusions.-The practice of dermatopathology and hematopathology varies widely. Thus, while this review provides an overview and guideline for the workup of lymphoid lesions of the skin, the practitioner should understand the importance of clinical correlation as well as appropriate utility of available resources (such as clonality testing) in arriving at a diagnosis in cutaneous lymphoid lesions.

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The value of molecular diagnostics in primary cutaneous B-cell lymphomas in the context of clinical findings, histology, and immunohistochemistry

Cited by 34 publications

References 28 publications

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

Early lymphoid lesions: conceptual, diagnostic and clinical challenges

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

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