The value of mediastinal staging with endobronchial ultrasound-guided transbronchial needle aspiration in patients with lung cancer☆

Petersen, Henrik; Eckardt, Jens; Hakami, Ardeshir; Olsen, Karen Ege; Jørgensen, Ole Dan

doi:10.1016/j.ejcts.2009.03.052

Cited by 34 publications

(9 citation statements)

References 11 publications

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“…According to our learning curve experience, the sensitivity and negative predictive value of EBUS‐TBNA in diagnosing lung cancer, as revealed by the first 30 examinations performed during training, were 86.96% and 70% respectively, analogous with results in prior studies involving learning curve procedures 11–14 . All three of the false negative cases during this time occurred in the first five procedures and a possible reason for these false negative cases was presumed to be an inadequate number of aspirations performed.…”

Section: Discussionsupporting

confidence: 75%

Role of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of bronchogenic carcinoma: Experience of a single institution in China

et al. 2010

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Objectives: To evaluate diagnostic yield and the safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for mediastinal/hilar lymph nodes and intrapulmonary masses. Methods: Between July 2009 and February 2010, 95 patients with mediastinal/hilar lymphadenopathy and/or intrathoracic peritracheal or peribronchial masses detected with computed tomography underwent EBUS-TBNA. One hundred and twelve samples were obtained from lymph nodes (LNs) and 11 samples were obtained from intrapulmonary lesions. All patients had cytological evaluation by smears and/or tissue evaluation of aspiration specimens. Results: Out of the 95 patients, 60 had lung cancer, 58 of these patients were diagnosed using EBUS-TBNA without onsite cytology assistance, false negative in 2 cases. Sensitivity the of convex probe EBUS-TBNA method in distinguishing benign from malignant lymph nodes or thoracic mass was 96.67%. In the absence of any major complications the procedure was uneventful. Conclusions: EBUS-TBNA seems a safe and effective technique in the diagnosis making bronchogenic carcinoma for mediastinal/hilar lymph nodes (LNs) and intrapulmonary masses.

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Section: Discussionsupporting

confidence: 75%

Role of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of bronchogenic carcinoma: Experience of a single institution in China

et al. 2010

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“…Likewise, squamous cell carcinomas accounted for 23.1% in patients with subcarinal metastases and for 18.3% of all patients with N2 disease (p ¼ 0.15). For all patients with N2 disease and for patients with subcarinal [17].…”

Section: Resultsmentioning

confidence: 99%

Subcarinal Lymph Nodes Should be Dissected in All Lobectomies for Non-Small Cell Lung Cancer—Regardless of Primary Tumor Location

Eckardt

Jakobsen

Licht

2017

The Annals of Thoracic Surgery

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“…[891112] Clinical studies have shown that EBUS-TBNA biopsy has sensitivity and specificity rates of 84%–100% overall and up to 100% in lung cancer. [4713–16]…”

Section: Discussionmentioning

confidence: 99%

Endobronchial ultrasound-guided transbronchial needle aspiration biopsy is useful evaluating mediastinal lymphadenopathy in a cancer center

et al. 2011

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Background:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy is used to stage mediastinal lymph nodes in cancer patients to optimize treatment strategies. In this retrospective study, the authors determined the utility of EBUS-TBNA biopsy in the evaluation of mediastinal lymphadenopathy at a high-volume cancer center.Materials and Methods:The pathology database was searched for all patients who had undergone EBUS-TBNA biopsy of mediastinal lymph nodes over a one-year period. Cytologic diagnoses were correlated with clinical histories, subsequent resection, and clinical follow-up data.Results:Of 928 lymph node samples, 226 (24%) were diagnosed as malignant, 4 (0.4%) were suspicious for malignancy, 9 (1%) were atypical, 640 (69%) were benign, and 47 (5%) were insufficient for evaluation. In 89 (9.6%) cases, the patients had surgical resection. There was one false positive, in which the primary tumor contained infiltrating lymphocytes, had been sampled. There were five false-negative cases, which resulted from sampling errors, including two with micrometastases. The sensitivity, specificity, and positive and negative predictive value rates for EBUS-TBNA biopsy in the evaluation of mediastinal lymph nodes were 68.7% and 98.6% and 91.6% and 93.5%, respectively on a per lymph node basis. The overall clinical sensitivity, specificity, and positive and negative predictive value rates after one year clinical/radiological and histologic follow-up were 97%, 99.3%, 96.7% and 99.4%, respectively.Conclusions:EBUS-TBNA biopsy is a sensitive and specific method for evaluating mediastinal lymphadenopathy in patients with lung and other primary tumors.

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The value of mediastinal staging with endobronchial ultrasound-guided transbronchial needle aspiration in patients with lung cancer☆

Cited by 34 publications

References 11 publications

Role of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of bronchogenic carcinoma: Experience of a single institution in China

Role of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of bronchogenic carcinoma: Experience of a single institution in China

Subcarinal Lymph Nodes Should be Dissected in All Lobectomies for Non-Small Cell Lung Cancer—Regardless of Primary Tumor Location

Endobronchial ultrasound-guided transbronchial needle aspiration biopsy is useful evaluating mediastinal lymphadenopathy in a cancer center

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