The value of magnetic resonance blood oxygen level-dependent imaging in evaluating the efficacy of advanced cervical cancer combined with radiotherapy and chemotherapy

Abstract

Background Blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is an imaging method used to analyze oxygenation status of the tumor. Purpose To investigate the feasibility of BOLD-MRI in evaluating the efficacy of advanced cervical cancer combined with radiotherapy and chemotherapy. Material and Methods This prospective study included 85 patients with advanced cervical cancer who received BOLD-MRI examination before and after concurrent chemoradiotherapy from October 2020 to December 2021. To investigate the changes of baseline R2* values and △R2* values of cervical cancers before and after treatment. Results 29 cases were complete response, 34 cases were partial response, and 22 cases showed progression. The baseline R2* values of the tumors were lower than that of the normal cervical muscle ( P < 0.0001). After oxygen stimulation, the baseline R2* values of the tumors decreased ( P = 0.012). After treatment, the baseline R2* values of the tumors increased ( P = 0.007), and the dynamic △R2* values of the tumors decreased ( P = 0.025). The baseline R2* value of the complete response was the highest ( P = 0.000), the dynamic △R2* value of the complete response was the lowest ( P = 0.017). Conclusion BOLD-MRI can evaluate the efficacy of concurrent chemoradiotherapy for advanced cervical cancer.

Magnetic Resonance Imaging in Atherosclerotic Renal Artery Stenosis: The Update and Future Directions from Interventional Perspective

“…Blood oxygenation level dependent (BOLD)-MRI, is a rapid imaging technique that does not require the use of contrast agents, enables noninvasive monitoring of tissue oxygenation and can be used repeatedly in a short amount of time [ 41 ]. BOLD-MRI utilizes the changes in the local magnetic field in local tissues triggered by paramagnetic deoxyhemoglobin in blood for imaging, and the concentration of deoxyhemoglobin in the tissue is quantitatively evaluated with apparent spin-spin relaxation rate (R2*, R2* = 1/T2*) [ 41 ]. The R2* value is directly proportional to the concentration of deoxyhemoglobin in the tissue and inversely proportional to the oxyhemoglobin concentration [ 42 ].…”