The value of intraoperative frozen section examination of sentinel lymph nodes in breast cancer

Vrande, Simon van de; Meijer, Jos W. R.; Rijnders, A.; Klinkenbijl, Jean H. G.

doi:10.1016/j.ejso.2008.07.016

Cited by 53 publications

(21 citation statements)

References 44 publications

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“…In our study sensitivity was higher for T2/3 tumors compared with T1 tumors showing a significant correlation (p<0.01) between tumor size and FS sensitivity. These results are comparable with those reported by Chan et al [35] and by Weiser et al [28], who found a significant increase of sensitivity of FS with tumor size, but are in contrast with those of other authors [36] who report the highest sensitivity of FS in T1a and T1b tumors, finding no significant difference between the sensitivity regarding T1a/b, T1c, and T2/3 tumors. In any case, we believe that intraoperative FS of SLN is, worthwhile, even in patients with small tumors, since SLN involvement >10% is reported in the larger tumors in the 5 to 15 mm range [37], therefore, making an ALND necessary.…”

Section: Discussionsupporting

confidence: 80%

“…The reported sensitivity of FS for the detection of SLN micrometastasis ranges from 10% to 52% [15,20,[28][29][30]. In a recent study on a large series of breast cancer patients, van de Vrande et al [36] report that the sensitivity of the FS examination was significantly greater when SLN contained macrometastasis compared to micrometastasis (84.0% versus 61.1%, p<0.001).…”

Section: Discussionmentioning

confidence: 92%

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The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma

Cipolla

Cabibi

Fricano

et al. 2009

Langenbecks Arch Surg

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 92%

The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma

Cipolla

Cabibi

Fricano

et al. 2009

Langenbecks Arch Surg

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“…We have previously discussed this point and concluded that multislice frozen section analysis was superior to imprint cytology in an intraoperative diagnosis of cancer metastasis in SN, even if it is a micrometastasis [8]. A review of the relevant literature on SN biopsies of breast cancer and melanoma conWrms why intraoperative frozen sections are so widely accepted [9][10][11][12].…”

Section: Discussionmentioning

confidence: 91%

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Terada

Hasegawa

Yatabe

et al. 2010

Eur Arch Otorhinolaryngol

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The objective of the study was to evaluate the validity of sentinel node (SN) biopsy in early oral cancer patients focusing on the accuracy of intraoperative diagnoses of SN status, recurrences in follow-up and impact on patient survival. Previously untreated N0 oral cancer patients were candidates for the study. Using a radioisotope method, an intraoperative SN biopsy was performed. Patients with a positive frozen section of SN underwent immediate neck dissection as a single-stage procedure; they were followed in our outpatient clinic. Forty-five cT1-2N0 patients with squamous cell carcinoma were analyzed. There were seven patients with positive SN, five of whom were detected by intraoperative frozen section analysis. The sensitivity, specificity and accuracy of the intraoperative frozen section analysis of SN were 71.4, 100 and 95.6%, respectively. There were 13 recurrences in the course of all patients treated. Those with positive SN showed a tendency toward recurrence. Three patients with negative SN suffered from delayed ipsilateral neck recurrence. These were considered false negatives at a rate of 7.9%. The 5-year overall survival rate of all patients was 91.1%. SN-positive patient survival was significantly poorer than that of SN-negative patients. Positive SN had a negative impact on the survival. SN biopsy was shown to be a valuable method for determining the neck status of early oral cancer patients. The concordance rate of intraoperative multislice frozen section analysis of SN and patient neck status at the time of operation was 95.6%. SN-positive patients exhibited a tendency toward cancer recurrence. There were three cases of false negatives not conforming to the SN concept and their rate was 7.9%. Positive SN had a negative impact on patient survival.

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“…48 Several studies have demonstrated that frozen section is less sensitive and assertive in detecting micrometastases (61.1%) than macrometastases (84%), with an overall sensitivity and specificity of 71.6% and 100%, respectively. 49 The efficacy of the current and standard histologic and immunohistochemical techniques in identifying occult metastasis has been questioned. As the driving force behind such reports, SN micrometastases seem to be implicated in cases of axillary recurrence.…”

Section: Pathologic Examinationmentioning

confidence: 99%

Sentinel Lymph Node Biopsy in Breast Cancer: A Comprehensive Literature Review

Salem

2009

Journal of Surgical Education

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The value of intraoperative frozen section examination of sentinel lymph nodes in breast cancer

Cited by 53 publications

References 44 publications

The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma

The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Sentinel Lymph Node Biopsy in Breast Cancer: A Comprehensive Literature Review

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