The value of hyperbilirubinaemia in the diagnosis of acute appendicitis

Emmanuel, Andrew; Murchan, P.; Wilson, Ian C.; Balfe, Paul

doi:10.1308/147870811x566402

Cited by 69 publications

(87 citation statements)

References 35 publications

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“…However, several studies have demonstrated that individually they are neither sufficient nor suitably specific for the diagnosis of acute appendicitis. [6] Aim of the present study was to illustrate diagnostic effectiveness of US in the diagnosis of acute appendicitis when combined with WBC and CRP levels.…”

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confidence: 99%

How To Avoid Negative Appendectomies: Can Us Achieve This?

Kartal¹

2016

Ulus Travma Acil Cerrahi Derg

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mentioning

confidence: 99%

How To Avoid Negative Appendectomies: Can Us Achieve This?

Kartal¹

2016

Ulus Travma Acil Cerrahi Derg

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“…The mean age (27.6) years. While in Emmanuel et al In his study including 472 patients, 254 patients (53.8%) were male and (46.2%) female and the mean age was (27) years [8]. While in Eren et al study group of 162 patients consisted of 97 (60%) men and 65 (40%) women with a median age of 36 years [9].…”

Section: Discussionmentioning

confidence: 93%

Validity of Serum Total Bilirubin as a Diagnostic Tool for Acute Appendicitis

Abouzeid¹,

Saleh²,

Zayed³

et al. 2017

Int J Surg Med

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Background: Acute appendicitis occurs through bacterial invasion in appendix leads to transmigration of bacteria and release of tumour necrosis factor (TNF)-alpha, Interleukin-6 (IL6) and cytokines. These reach the liver through a superior mesenteric vein and may produce inflammation or dysfunction of liver either directly or indirectly by altering hepatic blood flow with rising of total serum bilirubin. Objective: To evaluate the validity of elevated serum total bilirubin as a diagnostic marker for acute appendicitis and if elevated serum total bilirubin levels have a predictive potential for the diagnosis of complicated appendicitis. Methods: This is a prospective cross-section study including ninety-four (94) of adult patients have right iliac fossa pain attending to the Emergency Department (ED) at Suez Canal University Hospital. All 94 patients undergo total serum bilirubin measuring and postoperative histopathological examination of the removed appendix. Results: Amongst the patients diagnosed with acute appendicitis post-operatively, 57 patients (70.4%) were found to have elevated serum total bilirubin (>1.2mg/dL) while 24 patients (29.6%) had normal serum total bilirubin levels (≤ 1.2 mg/dL). Conclusion: Serum total bilirubin level appears to be a promising new laboratory marker for diagnosing acute appendicitis and have a predictive potential for the diagnosis of complicated appendicitis.

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“…6 There was a total of 2 cases unlikely to be appendix category, 30 cases in probable appendicitis category and 68 cases in acute appendix category.…”

Section: Discussionmentioning

confidence: 99%

“…4 Jaundice has been associated with appendicitis and studies have shown hyperbilirubinemia as a predictor of appendiceal perforation. 5,6 However, these studies have not focused on the value of bilirubin as a specific marker for acute appendicitis. 7 The present study will evaluate the relationship between hyperbilirubinemia and appendicitis and its predictive potential for the diagnosis of complicated appendicitis.…”

Section: Introductionmentioning

confidence: 99%

Hyperbilirubinemia as a diagnostic marker for acute appendicitis

Ambre

Chavan

2018

Int Surg J

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Background: Appendicitis is one of the commonest cause of abdominal pain requiring emergency surgery. Different clinical signs and symptoms always mimic the diagnosis of acute appendicitis with number of causes leading to pain in right iliac fossa, especially in females. Accurate diagnosis can be aided by additional tests. A delay in diagnosis can lead to appendiceal perforation with increased morbidity, and an appendectomy as soon as the condition is suspected, may increase the number of unnecessary appendicectomies. Objective of present study was to evaluate the role of hyperbilirubinemia as a diagnostic marker for Acute Appendicitis.Methods: This is a prospective study of 100 patients carried out at Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune from May 2015 to September 2017. Patients presenting to surgical OPD with pain in Right iliac fossa will be evaluated. Those with a clinical diagnosis of acute appendicitis will be included in the study.Results: Acute appendicitis is one of the most common emergencies and appendicectomy is one of the most frequently done abdominal operations. Clinical diagnosis using time tested clinical signs is effective in diagnosing appendicitis. However, bilirubin supports diagnosis and hence avoids chances of error in diagnosis. The investigation Bilirubin alone is not sufficient to accurately diagnose acute appendicitis, however the clinical findings, ALVARADO SCORE when combined can predict appendicitis. There is significant difference in total bilirubin in acute and probable cases of appendicitis but it can be used to differentiate both of them. In present study Mean bilirubin for acute appendicitis was 1.23mg/dl and probable cases of appendicitis was 0.84mg/dl, with SD for acute appendicitis was 0.598 and probable cases of appendicitis was 0.486. In our study bilirubin provide the highest diagnostic accuracy for acute appendicitis case. Normal inflammatory markers cannot exclude appendicitis, which remains a clinical diagnosis. The presence of history of pain and or signs of peritoneal inflammation which help you in diagnosing acute appendicitis.Conclusions: Hyperbilirubinemia can be a diagnostic marker for acute appendicitis.

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The value of hyperbilirubinaemia in the diagnosis of acute appendicitis

Abstract: Hyperbilirubinaemia is a valuable marker for acute appendicitis. Patients with hyperbilirubinaemia are also more likely to have appendiceal perforation or gangrene. Bilirubin should be included in the assessment of patients with suspected appendicitis.

Cited by 69 publications

References 35 publications

How To Avoid Negative Appendectomies: Can Us Achieve This?

How To Avoid Negative Appendectomies: Can Us Achieve This?

Validity of Serum Total Bilirubin as a Diagnostic Tool for Acute Appendicitis

Hyperbilirubinemia as a diagnostic marker for acute appendicitis

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