The Value of Histologic Grading and Staging, Random Biopsies,
Tumor and Bladder Mucosa Blood Group Antigens, in Predicting
Progression of Superficial Bladder Cancer

Huland, Hartwig; Klöppel, G.; Otto, Ulrich; Droese, M

doi:10.1159/000463506

Cited by 19 publications

(8 citation statements)

References 23 publications

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“…Our data confirm previously published results [4,11,12,14,15,18,19,20,21,23,24,25,26,28,32,34] in showing that urothelial bladder tumors are associated with histologic alterations of normal looking bladder mucosa. The severity and the occurrence of these lesions rises with the actual tumor grade and stage.…”

Section: Resultssupporting

confidence: 92%

“…2). ABH was studied using an immunoperoxydase technique [3,10,12,30,31 ] on the tumor as well as on the biopsies of the normal looking bladder mucosa. Tumors were graded from 1 to 3 and staged from 0 to B using the Jewett Marshall System.…”

Section: Resultsmentioning

confidence: 99%

“…These anomalies frequently extend to the prostatic urethra [5]. In the group of 20 patients in whom a biopsy of the prostatic urethra was obtained, the biopsy findings were considered abnormal in 12 patients (4 with dysplasia, 5 with CIS, 3 with hyperplasia) mainly with infiltrating tumors or CIS, although these lesions can be isolated more frequently in the presence of anom alies of the bladder mucosa [5,9,12].…”

Section: Resultsmentioning

confidence: 99%

“…Simultaneous determinations of blood group antigens fail to demonstrate a clear correlation between the antigenic status of the tumor and that of random biopsies. These results may help to clarify the indi cations of random mucosal biopsies which should be reserved to the treatment and surveillance of grade 3-tumors, irrespective of their stage.on the progression and recurrence of the bladder tumor is well accepted [1,11,12,23,24,25,27,34,35] and partially explained by cyto fluorometric [6,7] as well as blood surface antigen studies [3,10,12,30,31], There fore, it appears that random mucosal biopsies (RMB) play a definite role in the evaluation and follow-up of bladder tumors. However, routine RMB undoubtedly majors the invasiveness, cost and risks of endoscopic procedures.…”

mentioning

confidence: 95%

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Bladder Tumors: When to Do and What to Expect from Random Mucosal Biopsies with Reference to Blood Group Cell Surface Antigens

Boccon-Gibod¹,

Boccon‐Gibod²,

Desligneres³

et al. 1987

Eur Urol

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 95%

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Bladder Tumors: When to Do and What to Expect from Random Mucosal Biopsies with Reference to Blood Group Cell Surface Antigens

Boccon-Gibod¹,

Boccon‐Gibod²,

Desligneres³

et al. 1987

Eur Urol

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“…Microscopic depth of invasion has also been considered to be a major prognostic factor in low-stage disease [14]. Within the broad category of superficial disease, the marked difference in the survival rates of patients with pTa tumors and those showing penetration of the lamina propria justifies the differentiation between these categories.…”

Section: Discussionmentioning

confidence: 99%

Microstaging of pT1 Transitional Cell Carcinoma of the Bladder

Sözen

Akbal²,

Sökmensüer³

et al. 2002

Urol Int

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Introduction: Our objective was to evaluate the feasibility and value of microstaging in pT1 transitional cell carcinoma (TCC) of the bladder in a well-defined group of patients treated with transurethral resection (TUR) only. Materials and Methods: The clinical records of 152 patients who underwent TUR for the treatment of primary superficial TCC of the bladder between 1983 and 1997 were reviewed. Patients with primary carcinoma in situ and who received adjuvant intravesical treatments were excluded from study. We subclassified the pT1 tumors into two groups according to muscularis mucosae (MM) invasion (pT1 and pT1b). The recurrence and progression rate of cancers was analyzed according to the stage, grade, multiplicity and tumor size. Mean follow-up was 68 months. Estimation of the cumulative distribution of the disease-free interval in separate groups was calculated according to the Kaplan-Meier method. Multivariate analysis of the data was performed by using Cox regression method. A value of p < 0.05 was taken to be statistically significant with odds ratios. Results: Of the 152 patients, tumor stage was pTa in 62 (40.8%) patients and pT1 in 90 (59.2%) patients. Among those pT1 tumors, MM was identified in 50 (55.5%) of cases (pT1a = 34, pT1b = 16). In the remaining 40 (44.5%) patients, MM could not be assessed. Kaplan-Meier analysis revealed that recurrence and progression were statistically significant for stage, multiplicity and grade of tumor. However, multivariate analysis revealed that stage was the only prognostic factor for recurrence and progression (p = 0.0001). Conclusion: The present study underscores the fact that pT1b tumors have a distinct natural history. If initial conservative treatment is selected, the patients must be followed very cautiously.

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The relationship of ABH(O) blood group antigen expression in intraepithelial dysplastic lesions to clinicopathologic properties of associated transitional cell carcinoma of the bladder

Yamada

Fukui

Kobayashi

et al. 1991

Cancer

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Paraffin-embedded, giant-step sections of 13 bladders with transitional cell carcinomas were stained with monoclonal anti-A or anti-B antibodies to investigate whether intraepithelial dysplastic lesions are related to obvious tumors. Normal and/or hyperplastic lesions were retained in only eight bladders; severe dysplasia and/or carcinoma in situ were found in all bladders except two. AB-antigen expression was retained in intraepithelial lesions of bladders with invasive carcinoma. Most intraepithelial lesions were AB-antigen negative in bladders with frequently recurrent tumors. In bladders with initially multiple tumors, AB-antigen expression was negative in almost one half of the intraepithelial lesions. Therefore, it appears likely that most multiple or recurrent bladder carcinomas arise from dysplastic cells in intraepithelial lesions which have acquired malignant potential; initially invasive tumors quickly develop from a limited lesion acquiring a high malignant potential without changes of cell phenotype in most intraepithelial lesions.

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The Value of Histologic Grading and Staging, Random Biopsies, Tumor and Bladder Mucosa Blood Group Antigens, in Predicting Progression of Superficial Bladder Cancer

Cited by 19 publications

References 23 publications

Bladder Tumors: When to Do and What to Expect from Random Mucosal Biopsies with Reference to Blood Group Cell Surface Antigens

Bladder Tumors: When to Do and What to Expect from Random Mucosal Biopsies with Reference to Blood Group Cell Surface Antigens

Microstaging of pT1 Transitional Cell Carcinoma of the Bladder

The relationship of ABH(O) blood group antigen expression in intraepithelial dysplastic lesions to clinicopathologic properties of associated transitional cell carcinoma of the bladder

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