The value of Genus Acacia in arid and semi-arid environments for the treatment of chronic inflammatory diseases

Gum acacia dietary fiber: Significance in immunomodulation, inflammatory diseases, and cancer

“…However, the broad use of NSAIDs is constrained by their propensity to cause various side effects (Atiya et al, 2022). Hence, approximately 80% of the Western population relies on traditional medicines that originate from natural medicinal plants to support human health and combat diseases (Alsayari et al, 2021).…”

“…Risk factors contributing to these metabolic diseases include physical inactivity, dietary choices, high fat, and sucrose consumption, as well as environmental and genetic factors associated with various cancers (Atiya et al, 2022;Cani et al, 2008) (Figure 3). In our previous study, inclusion of GA in the high-fat diet led to reductions in body weight, adipocyte mass, and size, along with lowered levels of lipids and insulin.…”

“…The same research team also examined the hypoglycemic and lipid-lowering effects of GA in a randomized, placebo-controlled, double-blind clinical trial for T2D (Babiker et al, 2017). Additional comprehensive studies are available in existing literature (Atiya et al, 2022). In summary, GA enhances energy expenditure, bolsters intestinal integrity, reduces glucose and lipid levels, and alleviates inflammation linked to metabolic diseases, underscoring the need for further research to unveil its underlying molecular mechanisms.…”

“…Chronic inflammatory conditions encompass a wide range of disorders, including autoimmune diseases like RA, cardiovascular conditions such as hypertension and coronary heart disease, GI disorders like inflammatory bowel diseases (IBDs), and respiratory ailments like chronic obstructive pulmonary disease (COPD) and asthma. These conditions collectively account for a significant portion of global mortality, with 6 out of every 10 people worldwide affected by them (Atiya et al, 2022). The primary approach for managing chronic inflammatory conditions involves the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) to alleviate symptoms.…”

“…The primary approach for managing chronic inflammatory conditions involves the use of non‐steroidal anti‐inflammatory drugs (NSAIDs) to alleviate symptoms. However, the broad use of NSAIDs is constrained by their propensity to cause various side effects (Atiya et al, 2022). Hence, approximately 80% of the Western population relies on traditional medicines that originate from natural medicinal plants to support human health and combat diseases (Alsayari et al, 2021).…”