The value of FDG-PET in the detection, grading and response to therapy of soft tissue and bone sarcomas; a systematic review and meta-analysis

Bastiaannet, E.; Groen, Harry J.M.; Jager, Piet L.; Cobben, D.; Graaf, Winette T.A. van der; Vaalburg, W; Hoekstra, Harald J.

doi:10.1016/j.ctrv.2003.07.004

Cited by 267 publications

(121 citation statements)

References 35 publications

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“…MRI is the imaging of choice for extremity sarcoma and CT scan is preferred for retroperitoneal STS and for evaluation of lungs to rule out metastases [3]. Recently FDG-PET scan is being tried for imaging STS, predicting grade and assessment of response to neoadjuvant therapy [4]. A number of histopathological variants have been described in STS and an experienced pathologist is crucial for an accurate diagnosis of STS [5].…”

Section: Discussionmentioning

confidence: 99%

Soft Tissue Sarcoma—Review of Experience at a Tertiary Care Cancer Centre

Shukla

Deo

2011

Indian J Surg Oncol

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This study is a retrospective analysis of prospective data base of soft tissue sarcoma (STS) maintained in the department of Surgical Oncology, Bhim Rao Ambedkar Institute Rotary Cancer Hospital (BRA-IRCH), All India Institute of Medical Sciences, which is a tertiary care cancer centre. A total of 300 patients of STS were treated between 1995 and 2006. The mean age at presentation was 40.6 years and males were more affected then females. Extremity sarcomas were more common than non extremity sarcoma and lower limb dominated upper limb. The median size of tumor was 8 cm (range 1-40 cm). MRI scan was the preferred imaging modality and tissue diagnosis was obtained by core biopsy. Synovial Sarcoma and Malignant Fibrous Histiocytoma were the common histology. Majority (75%) tumors were of high grade. Patients were staged according to MSKCC staging system. Limb Salvage Surgery was offered to all patients where ever feasible. Wide excision with a gross three dimensional tumor free margin of 2 cm was performed. Adjuvant external beam radiotherapy was offered to all high grades, large and recurrent tumors along with perioperative brachytherapy implant for tumor bed. High grade tumors were also offered adjuvant Adriamycin based Chemotherapy. Limb salvage rate was 68% in extremity sarcoma. During follow up 114 (38%) patients had relapse of disease mainly systemic, lungs being the commonest site.

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Section: Discussionmentioning

confidence: 99%

Soft Tissue Sarcoma—Review of Experience at a Tertiary Care Cancer Centre

Shukla

Deo

2011

Indian J Surg Oncol

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“…Most previous studies for detecting sarcomas have been performed with 18 F-fluoro-2Ј-deoxy-D-glucose-PET (FDG-PET) and have recently been critically reviewed in two meta-analyses (31,32). The sensitivity of FDG-PET for detecting primary and recurrent sarcomas varies from 88 to 92%, and specificity varies form 73 to 87% (31,32).…”

Section: Discussionmentioning

confidence: 99%

“…During the last decade, the value of positron emission tomography (PET) in STS with several tracers, especially [ 18 F]fluoro-2Ј-deoxy-Dglucose (FDG), has been investigated (10 -16). However, the current potential of FDG-PET in the detection and/or grading is still unknown (10,11,15,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

Detection and Grading of Soft Tissue Sarcomas of the Extremities with 18F-3′-Fluoro-3′-Deoxy-l-Thymidine

Cobben

Elsinga

Suurmeijer

et al. 2004

Clinical Cancer Research

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Purpose: The aim of the study was to investigate the feasibility of 18 F-3-fluoro-3-deoxy-L-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS).Experimental Design: Nineteen patients with 20 STSs of the extremities were scanned, using attenuation corrected whole-body FLT-PET. Standardized uptake values (SUVs) and tumor:nontumor ratios (TNTs) were compared with histopathological parameters using French and Japanese grading systems.Results: Mean SUV, maximal SUV, and TNT could differentiate between low-grade (grade 1; n ‫؍‬ 6) STS and high-grade (grade 2 and 3; n ‫؍‬ 14) STS according to the French grading system (P ‫؍‬ 0.001). Mean SUV, max SUV, and TNT correlated with mitotic score, MIB-1 score, the French and Japanese grading system (• ‫؍‬ 0.550 -0.747).Conclusions: FLT-PET is able to visualize STS and differentiate between low-grade and high-grade STS. The uptake of FLT correlates with the proliferation of STS.

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“…Four patients died with local and regional widely used in detection of primary site in patients with unknown primary tumors, staging of various tumors, target delineation in radiotherapy planning and response evaluation in some tumors. Moreover the mean value of SUV max also demonstrated to be an important prognostic parameter in many tumors (El-Sayed et al, 1996;Rose et al, 1999;Hain et al, 2000;Bastiaannet et al, 2004;DeSantis et al, 2004;Scarfone et al, 2004;Schwartz et al, 2005;Thomas et al, 2005;Yao et al, 2005;Andrade et al, 2006;Higgins et al, 2012). FDG-PET CT imaging has become an important tool in the management of patients with HNC.…”

Section: Discussionmentioning

confidence: 99%

“…The appearance of edema, scar tissue, and treatmentrelated tissue changes result repeated endoscopic biopsies to identify persistent or recurrent disease which jeopardizes normal tissue healing in many patients. In addition anatomical complexity of head and neck region makes response evaluation rather difficult, post radiation changes and anatomic distortions after surgery further limit the diagnostic accuracy of these anatomic-based imaging studies in head and neck region (El-Sayed et al, 1996;Rose et al, 1999;Hain et al, 2000;Bastiaannet et al, 2004;DeSantis et al, 2004;Scarfone et al, 2004;Schwartz et al, 2005;Thomas et al, 2005;Yao et al, 2005;Andrade et al, 2006;Higgins et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Is FDG -PET-CT A Valuable Tool in Prediction of Persistent Disease in Head and Neck Cancer

Uzel¹,

Ekmekçioğlu²,

Eliçin³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Objectives: To evaluate accuracy of FDG-PET CT in prediction of persistent disease in head and neck cancer cases and to determine prognostic value of metabolic tumor response. Materials and Methods: Between 2009 and 2011, 46 patients with squamous cell carcinoma of head and neck receiving PET-CT were treated with definitive radiotherapy, with or without chemotherapy. There were 29 nasopharyngeal, 11 hypopharyngeal, 3 oropharyngeal and 3 laryngeal cancer patients, with a median age of 50.5 years (range 16-84), 32 males and 14 females. All patients were evaluated with PET-CT median 3-5 months (2.4-9.4) after completion of radiotherapy. Results: After a median 20 months of follow up, complete metabolic response was observed in 63% of patients. Suspicious residual uptake was present in 10.9% and residual metabolic uptake in 26.0% of patients. The overall sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET-CT for detection of residual disease was 91% and 81%, 64% and 96% respectively. Two year LRC was 95% in complete responders while it was 34% in non-complete responders. Conclusions: FDG PET CT is a valuable tool for assessment of treatment response, especially in patients at high risk of local recurrence, and also as an indicator of prognosis. Definitely more precise criteria are required for assessment of response, there being no clear cut uptake value indicating residual disease. Futhermore, repair processes of normal tissue may consume glucose which appear as increased uptake in control FDG PET CT.

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The value of FDG-PET in the detection, grading and response to therapy of soft tissue and bone sarcomas; a systematic review and meta-analysis

Cited by 267 publications

References 35 publications

Soft Tissue Sarcoma—Review of Experience at a Tertiary Care Cancer Centre

Soft Tissue Sarcoma—Review of Experience at a Tertiary Care Cancer Centre

Detection and Grading of Soft Tissue Sarcomas of the Extremities with 18F-3′-Fluoro-3′-Deoxy-l-Thymidine

Is FDG -PET-CT A Valuable Tool in Prediction of Persistent Disease in Head and Neck Cancer

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