The value of extensive catheter linear ablation on persistent atrial fibrillation (the CLEAR-AF Study)

Yao, Yan; Hu, Feng; Du, Zhongpeng; He, Jing; Shi, Haifeng; Zhang, Jinlin; Cai, Heng; Jia, Yuhe; Tang, Min; Niu, Guodong; Chen, Gang; Ding, Ligang; Zheng, Lihui; Liang, Erpeng; Wu, Lingmin

doi:10.1016/j.ijcard.2020.05.032

Cited by 14 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The P wave dispersion (PWD) has been reported to be related to ERAF or LRAF. In line with this, we found that the PWD in the ERAF group was signi cantly higher than that in the ERAF group (33 [25.5, 43] vs. 21 [11,31], p = 0.01).…”

Section: Differences In Clinical Characteristics Between Patients Wit...supporting

confidence: 83%

“…Thus, the ablation strategy for PerAF should be further explored. Yao et al [31] found that the ablation procedure in Group I (PVI + LA roof line+ LA anterior wall line) had higher success rate than Group II (PVI + LA roof line). Moreover, PVI combined roof and mitral isthmus line for PerAF ablation, can contribute to alteration of AF wavelet propagation, elimination of spectral components, reduction of excitable LA myocardial mass and attenuation of vagal innervation [32,33].…”

Section: Predictive Value Of Trpv2mentioning

confidence: 99%

See 1 more Smart Citation

Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation

Ling

Wang

Qin

et al. 2022

Preprint

View full text Add to dashboard Cite

Background:: Recent study has shown that the transient receptor potential vanilloid 2 (TRPV2) channel was exclusively upregulated in patients with atrial fibrillation (AF), and that this overexpression might be detrimental for occurrence and maintenance of AF. We aimed to characterize the expression levels of TRPV2 mRNA in peripheral blood mononuclear cells (PBMCs) with/without early recurrence of atrial fibrillation (ERAF) after radiofrequency catheter ablation (RFCA), and to find a reliable predictor for ERAF. Methods: 65 patients of AF, who underwent RFCA successfully, then divided into two groups according to ERAF during following 3 months. PBMCs were isolated from whole blood by Ficoll gradient centrifugation before and after RFCA. Gene set enrichment analysis (GSEA) was performed to evaluate TRPV channels expression levels and KEGG mapping was used for pathway enrichment analysis. Results: There was no significant difference in the TRPV2 mRNA expression level between the two groups before RFCA, while without ERAF group of TRPV2 expression was markedly reduced compared to ERAF group after RFCA. Moreover, the number of TRPV2 expression was confirmed as an independent predictor for the first time through receiver operation characteristic (ROC) and Kaplan-Meier survival curve analysis. It should be pointed out that the above results were only used to predict ERAF, and have no predictive significance for late recurrence of atrial fibrillation (LRAF) according to the current data. Additionally, ERAF was inversely correlated with P wave dispersion (PWD). KEGG mapping further clustered 41 pathways, revealing that ‘‘cGMP-PKG signaling pathway’’ was significantly enriched. Conclusions: We firstly assume that downregulated expression of peripheral TRPV2 appear in patients without ERAF after RFCA. TRPV2 may thus represent a novel predictor of early phase after successful radiofrequency ablation.

show abstract

Section: Differences In Clinical Characteristics Between Patients Wit...supporting

confidence: 83%

Section: Predictive Value Of Trpv2mentioning

confidence: 99%

Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation

Ling

Wang

Qin

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Thus, the ablation strategy for PerAF should be further explored. Yao et al [ 30 ] found that the ablation procedure in Group I (PVI + LA roof line + LA anterior wall line) had higher success rate than Group II (PVI + LA roof line). Moreover, PVI combined roof and mitral isthmus line for PerAF ablation, can contribute to alteration of AF wavelet propagation, elimination of spectral components, reduction of excitable LA myocardial mass and attenuation of vagal innervation [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation

Ling

Wang

Qin

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Recent study has shown that the transient receptor potential vanilloid 2 (TRPV2) channel was exclusively upregulated in patients with atrial fibrillation (AF), and that this overexpression might be detrimental for occurrence and maintenance of AF. We aimed to characterize the expression levels of TRPV2 mRNA in peripheral blood mononuclear cells (PBMCs) with/without early recurrence of atrial fibrillation (ERAF) after radiofrequency catheter ablation (RFCA), and to find a reliable predictor for ERAF. Methods 65 patients of AF, who underwent RFCA successfully, then divided into two groups according to ERAF during following 3 months. PBMCs were isolated from whole blood by Ficoll gradient centrifugation before and after RFCA. Gene set enrichment analysis was performed to evaluate TRPV channels expression levels and Kyoto Encyclopedia of Genes and Genomes (KEGG) mapping was used for pathway enrichment analysis. Results There was no significant difference in the TRPV2 mRNA expression level between the two groups before RFCA, while without ERAF group of TRPV2 expression was markedly reduced compared to ERAF group after RFCA. Moreover, the number of TRPV2 expression was confirmed as an independent predictor for the first time through receiver operating characteristic and Kaplan–Meier survival curve analysis. It should be pointed out that the above results were only used to predict ERAF, and have no predictive significance for late recurrence of atrial fibrillation according to the current data. Additionally, ERAF was inversely correlated with P wave dispersion. KEGG mapping further clustered 41 pathways, revealing that ‘‘cyclic guanosine monophosphate-protein kinase G signaling pathway’’ was significantly enriched. Conclusions We firstly assume that downregulated expression of peripheral TRPV2 appear in patients without ERAF after RFCA. TRPV2 may thus represent a novel predictor of early phase after successful radiofrequency ablation.

show abstract

“…By contrast, adjunctive anterior line ablation for PsAF patients seems unproductive. The Clear AF [30] study showed that an anterior line of ablation in addition to PVI and a roof line did not improve sinus rhythm maintenance rate after 2 years of follow-up. Moreover, left atrial dyssynchrony and hypofunction were reported after such aggressive ablation strategies for PsAF patients [31].…”

Section: Key Pointsmentioning

confidence: 96%

Risk and benefit of extrapulmonary vein ablation in atrial fibrillation

Liao

Katrapati

Bai

2022

Current Opinion in Cardiology

View full text Add to dashboard Cite

Purpose of reviewThis review aims to summarize the recent development, benefit, and safety of extrapulmonary vein ablation for atrial fibrillation. Recent findingStudies have shown that extrapulmonary vein ablation can help maintain normal sinus rhythm for patients with persistent atrial fibrillation. As prior strategies targeting anatomical lines and triggers are well utilized, novel techniques for substrate mapping have been rapidly developing. These strategies are well tolerated and could be chosen based on patients'conditions and physicians experience. SummaryExtrapulmonary vein ablation could be safely and effectively performed for patients with atrial fibrillation. It provides further consolidation of normal sinus rhythm.

show abstract

The value of extensive catheter linear ablation on persistent atrial fibrillation (the CLEAR-AF Study)

Cited by 14 publications

References 24 publications

Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation

Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation

Predictive value of TRPV2 expression from peripheral blood mononuclear cells on the early recurrence of atrial fibrillation after radiofrequency catheter ablation

Risk and benefit of extrapulmonary vein ablation in atrial fibrillation

Contact Info

Product

Resources

About