The Value of Emerging Prostate Cancer-associated lncRNA PCGEM1 in Various Tumors

Abstract

Background: LncRNA not only plays an auxiliary role as an intermediate carrier of genetic information, but also mediates various regulatory functions. The complex and precise regulatory function of lncRNA in development and gene expression has greatly explained the complexity of the genome, and also opened a new avenue for people to understand the complexity of life from the dimension of gene expression. Long non-coding RNA (lncRNA) prostate cancer gene expression marker 1 (PCGEM1) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to summarizing the various molecular mechanisms of PCGEM1 and demonstrates that the biological functions exerted by PCGEM1 are good starting points for therapy. Methods: The molecular mechanism of PCGEM1 acting on tumors has been summarized by reviewing the literature available on PubMed. Results: The expression of lncRNA PCGEM1 is abnormally increased in all kinds of tumors, including cervical cancer, prostate cancer, renal carcinoma, gastric cancer, lung cancer, ovarian carcinoma, cough variant asthma, and castration tolerant prostate cancer. Besides, PCGEM1 mediates multiple processes involved in carcinogenesis, including proliferation, invasion, anti-apoptosis, and migration. Conclusion: The potential of PCGEM1 as a therapeutic target for cancer is revealed.