The Value of Different Therapeutic Agents in the Treatment of Rickets

Macrae, Olive

doi:10.1136/adc.5.30.431

Cited by 2 publications

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“…(ii) 3-431 (iii) 3:617 (iv) :3 601 5 (i) [5][6][7][8][9][10][11][12][13][14] (ii) as good as in health. Schaap12 found that the percentage of nlitIrogeln inl the foeces was practically the same as normal: owsing to the excess in the anmount of fiuces passed there wN-as natuirally a miuch greater loss of nitrogeni than in health.…”

Section: Atctiives Of Disease In Childhoodmentioning

confidence: 99%

Metabolism Studies in C liac Disease

Macrae¹,

Morris²

1931

Archives of Disease in Childhood

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Since the publication of Cheadle's paper' in 1903, the presence of excess of fat in the foeces has attracted much notice as the most characteristic signi of the metabolic disturbainee in cceliac disease. It ha,s beein recognized that associated with this disturbance of fat absorption, there occuirs also a defective retention of minerals and an excessive loss of nitroge.n in the feeces. In consequence some attention hias been paid to the effect of varying the composition of the dietarv, especially fromi the therapeuitic standpoint. The interrelationship of the disturbanices in the absorption of the various elements of the diet is a m4atter of importance both from the practical point of view, an(d l)ecause of the possible value in the explanation of other metabolic disor(lers.Parsons2 has already indicated the importa,nce of vitanmin D in the preventioni of cceliac rickets, showing that the continued absence of this vitanmin from the fat-poor diets used in treatment is the cause of the rickets of convalescence. The series of observations detailed in this paper are published in the hope that some further light nay be throwin onl the und(lerlying chemical pathology of the cceliac state. A more complete understanding of the disorder should ultimately prove of value in the prevention and cure of the disease.Metabolic studies in eoliae disease are subject to the great disadva,ntage that sudden changes oecur in the condition of the patient although the diet is constant and the environment unaltered. Accordingly it is difficult to determine whether differences in the metabolic findings are to be attribuited to changes in food or other treatment, or to nattural aggravation or amelioration of the condition. In these investigations as unich care as possible was taken to rule out the idiopathic changes in the severity of the disease. A brief description of the salient featuires of the case-histories of the patients is appended at the end of the paper (see Appendix). It is proposed in the first place to summarize the metabolic findings with regard to the various forms of foodstuffs and thereafter to discuiss the bearing of these results on the chemical pathogenesis of coeliac disease.

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Section: Atctiives Of Disease In Childhoodmentioning

confidence: 99%