The Value of Cytometric DNA Analysis as a Prognostic Tool in Neuroendocrine Neoplastic Diseases

Falkmer, Ursula Gerda Inge; Falkmer, Sture

doi:10.1016/s0344-0338(11)80883-6

Cited by 14 publications

(7 citation statements)

References 54 publications

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“…Falkmer et al [9,10] reported different ploidy states in cells of neuroendocrine tumours using a methodological approach similar to the present study.…”

Section: Discussionsupporting

confidence: 70%

Correlation between p53 Status, DNA Ploidy, Proliferation Rate and Nuclear Morphology in Breast Cancer. An Image Cytometric Study

Friedrich

Dimmer

Haroske

et al. 1997

Analytical Cellular Pathology

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The study was designed to detect differences in the nuclear morphology of tumours and tumour cell populations with different p53 expression in correlation with DNA ploidy and proliferation rate. The paraffin sections from routinely processed samples of 88 breast cancers were immunostained with the monoclonal p53‐antibody DO‐1. After localization and evaluation with a scoring system the sections were destained and stained by the Feulgen method. The nuclei were relocated automatically and measured by means of the image cytometry workstation. Significant differences between the tumours and tumour cell populations with different p53 expression were found in the euploid tumours as well as in the aneuploid tumours and in the breast cancers with a high proliferation rate. The breast cancers with a low immunoreactive score (IRS 1–4) differ from the negative cancers as well as from the cancers with a higher immunoreactive score (IRS 5–12). Evaluating the nuclear populations of the p53 positive cancers, there were differences in the features of the chromatin amount and distribution in the groups of the euploid breast cancers and in cancer with a high proliferation rate. In contrast, the nuclear populations of the aneuploid cancers did not show any differences in their nuclear morphology.The results showed the different impacts of the p53 expression, DNA ploidy and the proliferation rate on the nuclear morphology in breast cancer.

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“…Falkmer et al [9,10] reported different ploidy states in cells of neuroendocrine tumours using a methodological approach similar to the present study.…”

Section: Discussionsupporting

confidence: 70%

Correlation between p53 Status, DNA Ploidy, Proliferation Rate and Nuclear Morphology in Breast Cancer. An Image Cytometric Study

Friedrich

Dimmer

Haroske

et al. 1997

Analytical Cellular Pathology

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“…24 Tumor cell DNA content was analyzed using single-cell image cytometry or flow cytometry. 25 Near-triploid DNA content was considered if the DNA index ranged from 1.25 to 1.75.…”

Section: Genetic Studiesmentioning

confidence: 99%

Role of urokinase plasminogen activator and its receptor in metastasis and invasion of neuroblastoma

Gao¹,

Ji²,

Zhang³

et al. 2004

Journal of Pediatric Surgery

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“…Tumor cell DNA content was analyzed using single cell image cytometry and/or flow cytometry [17]. Near-triploid DNA content was considered if the DNA index ranged from 1.25 to 1.75.…”

Section: Genetic Studiesmentioning

confidence: 99%

Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas

Schilling

Ambros

Bihl

et al. 2001

Med. Pediatr. Oncol.

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The Value of Cytometric DNA Analysis as a Prognostic Tool in Neuroendocrine Neoplastic Diseases

Cited by 14 publications

References 54 publications

Correlation between p53 Status, DNA Ploidy, Proliferation Rate and Nuclear Morphology in Breast Cancer. An Image Cytometric Study

Correlation between p53 Status, DNA Ploidy, Proliferation Rate and Nuclear Morphology in Breast Cancer. An Image Cytometric Study

Role of urokinase plasminogen activator and its receptor in metastasis and invasion of neuroblastoma

Absence of somatostatin receptor expression in vivo is correlated to di- or tetraploid 1p36-deleted neuroblastomas

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