The value of correctly diagnosing axial spondyloarthritis for patients and society

Webers, Casper; Grimm, Sabine; Tubergen, Astrid van; Gaalen, F. van; Heijde, Desirée van der; Joore, Manuela A.; Boonen, Annelies

doi:10.1016/j.semarthrit.2023.152242

Cited by 1 publication

(1 citation statement)

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“…Studies have also highlighted the financial repercussions of delayed diagnosis of axSpA, with data from Italy revealing substantial expenses of approximately EUR 153,000 incurred in the 3 years prior to a confirmed SpA diagnosis [ 25 ]. On the other hand, a correct diagnosis of axSpA results in substantial health and cost benefits for patients and society; for each correctly diagnosed axSpA patient, up to EUR 60,000 could be gained/saved [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Pathogenesis of Spondylarthritis beyond HLA-B27: A Descriptive Review

Nagit,

Rezus,

Cianga

2024

IJMS

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Spondylarthritis (SpA) is a chronic inflammatory condition that encompasses damage to the axial or peripheral skeleton, accompanied by specific extra-articular symptoms. Within this group, Ankylosing Spondylitis stands out as the hallmark member. Although the heritability of Ankylosing Spondylitis is estimated to be over 95%, only a portion of the heritability has been explained, with HLA-B27 accounting for 20.1% of it; therefore, ongoing research endeavors are currently concentrated on investigating the potential participation of different entities in the development of the disease. Genome-wide association studies have led to significant advances in our understanding of the genetics of SpA. In this descriptive review, we delve into the pathogenesis of Spondylarthritis beyond HLA-B27. We summarize the latest research on the potential participation of various entities in the development of the disease, including other genetic loci, immune dysregulation, microbiota, and environmental factors. The multifactorial nature of SpA and the complex interplay of genetic, immunological, and environmental factors are being increasingly recognized; therefore, it is of paramount importance to consider a holistic approach to comprehend the pathogenesis of SpA in order to identify novel therapeutic targets.

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Section: Introductionmentioning

confidence: 99%