Abstract:Objective: To investigate the value of computed tomography-guided percutaneous lung biopsy (CT-PLB) combined with rapid on-site evaluation (ROSE) in the diagnosis of peripheral pulmonary lesions (PPLs). Methods: A total of 108 patients who diagnosed with PPLs by chest CT examination were prospectively collected and randomly divided into ROSE group (n = 56) and No-ROSE group (n = 52). Both groups received CT-PLB and pathological examination. The smear submitted for ROSE was stained using Diff Quik dye. The accu… Show more
“…Of these 7 studies, 2 were RCTs [ 16 , 18 ] while 5 were retrospective in nature [ 17 , 19 – 22 ]. Both RCTs exhibited an unclear risk of bias with respect to performance, detection, and reporting (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…NOS scores for the included retrospective analyses ranged from 7–8. Core needles were used for LB procedures in 4 studies [ 17 , 20 – 22 ], while 1 used a fine needle biopsy approach [ 19 ], and two studies did not specify the needle type(s) used [ 16 , 18 ] (Table 1 ). Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In total, 4 studies reported diagnostic accuracy rates [ 17 , 18 , 21 , 22 ]. These pooled diagnostic accuracy rates were significantly higher for patients who underwent CT-guided LB with ROSE relative to those who underwent CT-guided LB alone (94.0% vs. 83.2%, OR: 3.16, P < 0.00001, Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Four studies reported data pertaining to operative duration [ 16 – 18 , 20 ]. No significant differences in these pooled operative duration values were observed when comparing study groups (MD: -0.14, P = 0.86, Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Three studies provided data regarding the number of punctures [ 16 , 18 , 20 ], with no significant differences in this number between study groups in pooled analyses (MD: − 0.23, P = 0.60, Fig. 3 e).…”
Background
Lung biopsy (LB) procedures performed with computed tomography (CT guidance can enable the reliable diagnosis of lung lesions. These diagnostic efforts can be further expedited through a rapid on-site evaluation (ROSE) approach, allowing for the rapid assessment of collected tissue samples to gauge the adequacy of these samples, their features, and associated cytomorphological characteristics. The present analysis was developed to examine the safety and efficacy of CT-guided LB with ROSE as a means of diagnosing lung lesions.
Methods
Studies published as of July 31, 2022 in the PubMed, Embase, and Wanfang databases were identified for this meta-analysis. Diagnostic accuracy was the primary endpoint, while secondary endpoints included the operative duration, the number of punctures, and rates of lung hemorrhage, pneumothorax, and secondary LB.
Results
This meta-analysis included 6 total studies. Relative to CT alone, CT with ROSE was associated with a significant increase in diagnostic accuracy (P < 0.00001). In contrast, there were no significant differences between these two groups with respect to the operative duration (P = 0.86), the number of punctures (P = 0.60), or the rates of pneumothorax (P = 0.82) or lung hemorrhage (P = 0.81). Pooled secondary LB rates were significantly lower for patients that underwent CT with ROSE relative to patients in the CT only group (P = 0.0008). Significant heterogeneity was detected for the operative duration (I2 = 94%) and number of punctures (I2 = 98%) endpoints, while no publication bias was detected for any study endpoints.
Conclusions
These results suggest that ROSE may contribute to significant improvements in the diagnostic accuracy of CT-guided LB without contributing to higher rates of complications.
“…Of these 7 studies, 2 were RCTs [ 16 , 18 ] while 5 were retrospective in nature [ 17 , 19 – 22 ]. Both RCTs exhibited an unclear risk of bias with respect to performance, detection, and reporting (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…NOS scores for the included retrospective analyses ranged from 7–8. Core needles were used for LB procedures in 4 studies [ 17 , 20 – 22 ], while 1 used a fine needle biopsy approach [ 19 ], and two studies did not specify the needle type(s) used [ 16 , 18 ] (Table 1 ). Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In total, 4 studies reported diagnostic accuracy rates [ 17 , 18 , 21 , 22 ]. These pooled diagnostic accuracy rates were significantly higher for patients who underwent CT-guided LB with ROSE relative to those who underwent CT-guided LB alone (94.0% vs. 83.2%, OR: 3.16, P < 0.00001, Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Four studies reported data pertaining to operative duration [ 16 – 18 , 20 ]. No significant differences in these pooled operative duration values were observed when comparing study groups (MD: -0.14, P = 0.86, Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Three studies provided data regarding the number of punctures [ 16 , 18 , 20 ], with no significant differences in this number between study groups in pooled analyses (MD: − 0.23, P = 0.60, Fig. 3 e).…”
Background
Lung biopsy (LB) procedures performed with computed tomography (CT guidance can enable the reliable diagnosis of lung lesions. These diagnostic efforts can be further expedited through a rapid on-site evaluation (ROSE) approach, allowing for the rapid assessment of collected tissue samples to gauge the adequacy of these samples, their features, and associated cytomorphological characteristics. The present analysis was developed to examine the safety and efficacy of CT-guided LB with ROSE as a means of diagnosing lung lesions.
Methods
Studies published as of July 31, 2022 in the PubMed, Embase, and Wanfang databases were identified for this meta-analysis. Diagnostic accuracy was the primary endpoint, while secondary endpoints included the operative duration, the number of punctures, and rates of lung hemorrhage, pneumothorax, and secondary LB.
Results
This meta-analysis included 6 total studies. Relative to CT alone, CT with ROSE was associated with a significant increase in diagnostic accuracy (P < 0.00001). In contrast, there were no significant differences between these two groups with respect to the operative duration (P = 0.86), the number of punctures (P = 0.60), or the rates of pneumothorax (P = 0.82) or lung hemorrhage (P = 0.81). Pooled secondary LB rates were significantly lower for patients that underwent CT with ROSE relative to patients in the CT only group (P = 0.0008). Significant heterogeneity was detected for the operative duration (I2 = 94%) and number of punctures (I2 = 98%) endpoints, while no publication bias was detected for any study endpoints.
Conclusions
These results suggest that ROSE may contribute to significant improvements in the diagnostic accuracy of CT-guided LB without contributing to higher rates of complications.
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