1985
DOI: 10.1016/0009-8981(85)90148-2
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The value of combined determination of high molecular mass API and LP-X in the differential diagnosis of intrahepatic and extrahepatic obstruction

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Cited by 5 publications
(3 citation statements)
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“…Alkaline phosphatase (AP) shares some common features with GT: both enzymes are sensitive indicators of cholestasis (218,219); they show a considerable heterogeneity in normal serum and particularly in patients' sera; and they demonstrate a tendency to react with serum constituents and to form macromolecular complexes. Serum AP may be released by liver, bone, placenta, or intestine.…”
Section: Analytes Of Clinical Interestmentioning
confidence: 99%
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“…Alkaline phosphatase (AP) shares some common features with GT: both enzymes are sensitive indicators of cholestasis (218,219); they show a considerable heterogeneity in normal serum and particularly in patients' sera; and they demonstrate a tendency to react with serum constituents and to form macromolecular complexes. Serum AP may be released by liver, bone, placenta, or intestine.…”
Section: Analytes Of Clinical Interestmentioning
confidence: 99%
“…Particularly in cholestasis several electrophoretic AP bands have been observed and a number of names proposed (218). Besides isoenzymes originating from liver, bone, placenta, and intestine, macromolecular forms are of specific interest: in cholestasis a liver AP-lipoprotein-X complex is seen (219), in hepatic malignancy a membraneparticle-AP is present, and, without special relation to any disorders, a Ig-linked AP has been identified (218,298). Ectopic or inappropriate expression of AP in tumors now is a well-recognized phenomenon.…”
Section: Analytes Of Clinical Interestmentioning
confidence: 99%
“…The F-ALP is a high-molecular-weight and highly neg atively charged fraction of ALP in serum and is also called high-molecular-weight ALP [11,12], The origin of the fast liver isoenzyme is not yet completely clear, but these enzyme complexes also occur in bile and may be regurgi tated into blood in biliary obstruction [13,14], The pres ence of the fast liver fraction in serum is therefore regarded as a sign of cholestatic disease [12,15] or liver metastasis [16] which could be excluded in our patients. Fast liver isoenzyme correlated to parameters of hepato biliary disease such as GGT, total ALP, L-ALP, ALAT and ASAT, but also with parameters of disease activity as CDAI, OM, ESR and platelets.…”
Section: Discussionmentioning
confidence: 99%