The value of circulating long non‐coding RNA maternally expressed gene 3 as a predictor of higher acute respiratory distress syndrome risk and 28‐day mortality in sepsis patients

Wu, Xiaoling; Chen, Dan; Yu, Li

doi:10.1002/jcla.23488

Cited by 10 publications

(11 citation statements)

References 20 publications

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“…In this study, we found that more nonsurvivors were male, older and had MODS than survivors, which has been validated in various studies 14,15 …”

Section: Discussionsupporting

confidence: 65%

“…In this study, we found that more nonsurvivors were male, older and had MODS than survivors, which has been validated in various studies. 14,15 The multivariable logistic analysis also suggested that lower albumin and CRP were independent risk factors for a 28-day poor prognosis of ARDSp based on the 10 years of clinical data, especially CRP, which seemed to be a paradox.…”

Section: Discussionmentioning

confidence: 97%

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An online nomogram of acute respiratory distress syndrome originating from pulmonary disease

Wang

Tang

et al. 2021

Eur J Clin Investigation

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Background Acute respiratory distress syndrome (ARDS) is a highly heterogeneous disease accompanied by high mortality. Our goal was to investigate the risk factors for 28‐day mortality and then establish a predictive online nomogram for ARDS originating from pulmonary disease (ARDSp). Methods We examined 1087 patients diagnosed with ARDS from January 2010 to December 2019 at the Second Affiliated Hospital of Chongqing Medical University. A total of 185 ARDSp patients were finally enrolled in the training cohort. A total of 43 ARDSp patients from January 2020 to August 2021 in the Second Affiliated Hospital of Chongqing Medical University and the Traditional Chinese Medical Hospital of Jiangbei District were included in the external validation cohort. Fundamental, clinical and laboratory variables at admission were gathered from medical records, and the 28‐day prognosis was followed up. Results In the training cohort, it was found that age, sex, C‐reactive protein, albumin and multiple organ dysfunction syndrome (MODS) were independent risk factors for 28‐day mortality via multivariate logistic regression. The online nomogram software for 28‐day mortality showed good discrimination, calibration and clinical utility in both the training cohort and external validation cohort. Conclusions For ARDSp patients, older males, lower C‐reactive protein and albumin levels, and MODS were independent predictors of a poor 28‐day prognosis. The online nomogram based on five independent factors could act as a predictive appliance in clinical practice.

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“…In this study, we found that more nonsurvivors were male, older and had MODS than survivors, which has been validated in various studies 14,15 …”

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 97%

An online nomogram of acute respiratory distress syndrome originating from pulmonary disease

Wang

Tang

et al. 2021

Eur J Clin Investigation

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show abstract

“…In another study, Gui et al concluded that lncRNA Antisense non-coding RNA in the INK4 locus (ANRIL)/miR-125a axis was upregulated in sepsis patients (107), which suggest that ANRIL could work as another potential biomarker for sepsis risk and severity. Several studies have suggested that lncRNA maternally expressed gene 3 (MEG3) might serve as a valuable indicator for the progression of sepsis, providing new strategy against acute respiratory distress syndrome in sepsis (108,109).…”

Section: Lncrnas In Diagnosis and Prognosis Of Sepsismentioning

confidence: 99%

Long Non-Coding RNAs as Biomarkers and Therapeutic Targets in Sepsis

et al. 2021

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Sepsis, an infection-induced systemic inflammatory disorder, is often accompanied by multiple organ dysfunction syndromes with high incidence and mortality rates, and those who survive are often left with long-term sequelae, bringing great burden to social economy. Therefore, novel approaches to solve this puzzle are urgently needed. Previous studies revealed that long non-coding RNAs (lncRNAs) have exerted significant influences on the process of sepsis. The aim of this review is to summarize our understanding of lncRNAs as potential sepsis-related diagnostic markers and therapeutic targets, and provide new insights into the diagnosis and treatment for sepsis. In this study, we also introduced the current diagnostic markers of sepsis and discussed their limitations, while review the research advances in lncRNAs as promising biomarkers for diagnosis and prognosis of sepsis. Furthermore, the roles of lncRNAs in sepsis-induced organ dysfunction were illustrated in terms of different organ systems. Nevertheless, further studies should be carried out to elucidate underlying molecular mechanisms and pathological process of sepsis.

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“…As a major protein related to innate immune and inflammatory responses, TLR3 is known to cause cardiac dysfunction and other organ damage during sepsis ( 74 , 75 ). Low expression of lnc-MEG3 might also serve as a potential biomarker for the development, progression, and prognosis prediction of sepsis ( 76 – 78 ). Furthermore, overexpression of MEG3 prevented LPS-induced macrophage apoptosis and secretion of inflammatory factors by inhibiting activation of the NF-κB signaling pathway ( 77 ).…”

Section: Lncrna Involved In Sicd Among Various Cell Typesmentioning

confidence: 99%

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

Zhang

et al. 2021

Front. Cardiovasc. Med.

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Sepsis is a syndrome with life-threatening organ dysfunction induced by a dysregulated host response to infection. The heart is one of the most commonly involved organs during sepsis, and cardiac dysfunction, which is usually indicative of an extremely poor clinical outcome, is a leading cause of death in septic cases. Despite substantial improvements in the understanding of the mechanisms that contribute to the origin and responses to sepsis, the prognosis of sepsis-induced cardiac dysfunction (SICD) remains poor and its molecular pathophysiological changes are not well-characterized. The recently discovered group of mediators known as long non-coding RNAs (lncRNAs) have presented novel insights and opportunities to explore the mechanisms and development of SICD and may provide new targets for diagnosis and therapeutic strategies. LncRNAs are RNA transcripts of more than 200 nucleotides with limited or no protein-coding potential. Evidence has rapidly accumulated from numerous studies on how lncRNAs function in associated regulatory circuits during SICD. This review outlines the direct evidence of the effect of lncRNAs on SICD based on clinical trials and animal studies. Furthermore, potential functional lncRNAs in SICD that have been identified in sepsis studies are summarized with a proven biological function in research on other cardiovascular diseases.

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The value of circulating long non‐coding RNA maternally expressed gene 3 as a predictor of higher acute respiratory distress syndrome risk and 28‐day mortality in sepsis patients

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 10 publications

References 20 publications

An online nomogram of acute respiratory distress syndrome originating from pulmonary disease

An online nomogram of acute respiratory distress syndrome originating from pulmonary disease

Long Non-Coding RNAs as Biomarkers and Therapeutic Targets in Sepsis

The Role of Long Non-coding RNAs in Sepsis-Induced Cardiac Dysfunction

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