The value of circulating fibrinogen-to-pre-albumin ratio in predicting survival and benefit from chemotherapy in colorectal cancer

Ying, Hou-Qun; Sun, Fan; Liao, Yu-Cui; Cai, David; Yang, Ying; Cheng, Xue-Xin

doi:10.1177/17588359211022886

Cited by 14 publications

(18 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prognostic cut-off values of FPR within stage I and II CRC were 14.0 and 16.5, respectively, as reported in our previous study [ 16 ]. Binary and continuous variables were summarized as numbers and frequencies and medians and quartiles, respectively.…”

Section: Methodssupporting

confidence: 75%

“…Our previous studies showed that high-grade chronic inflammation could attenuate chemosensitivity or even chemoresistance. Patients with low-grade FPR (≤ 15) showed complete response to CT; however, median-grade FPR (20 ≥ FPR > 15) and high-grade FPR (> 20) implied chemosensitivity and chemoresistance in CRC patients [ 16 ]. This study found that CT-treated FPR > 20 patients harbored the highest recurrence and death rates.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Quantification of fibrinogen-to-pre-albumin ratio provides an integrating parameter for differential diagnosis and risk stratification of early-stage colorectal cancer

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Circulating fibrinogen to pre-albumin ratio (FPR) and albumin to fibrinogen ratio (AFR) are effective factors for predicting the prognosis of colorectal cancer (CRC). However, the role of these two ratios in diagnosing early-stage CRC and identifying the stage II CRC subgroup with high relapse risk remains unknown. This study aimed to assess the potential of FPR and AFR in differential diagnosis and risk stratification of early-stage CRC. Methods A discovery (694 and 512 patients with benign colorectal polyps and stage I–II CRC, respectively) and validation (201 benign colorectal polyps cases and 202 stage I–II CRC individuals) cohorts were enrolled in this study. Receiver operating characteristic curve (ROC), Kaplan–Meier curve, and time-dependent ROC were used to evaluate the diagnostic efficacy of AFR and FPR in the two cohorts and overall population, and the discriminating role of FPR in identifying clinical high-relapse risk patients in comparison with common clinical characteristics in stage II CRC patients. Results The area under the curve (AUC) of the preoperative circulating FPR was higher than that of AFR in the diagnosis of stage I–II CRC from colorectal adenomas and benign colorectal polyps in the discovery and validation cohorts and overall population. Carcinoembryonic antigen (CEA) combined with FPR could effectively discriminate early-stage CRC from colorectal adenomas or benign polyps. Preoperative FPR could effectively distinguish stage II subgroups with high and low relapse risk. It was superior to common clinical characteristics in identifying high-risk surgical patients who could benefit from adjuvant chemotherapy (CT) [time-dependent AUC: 0.637 vs. 0.511, p < 0.001 for predicting recurrence-free survival (RFS); 0.719 vs. 0.501, p < 0.001 for predicting overall survival (OS)]. Furthermore, CT treated stage II patients with FPR > 20 had the highest recurrence (31.16%) and death rates (21.88%), with similar highest recurrence (30.70%) and death (26.82%) rates found in non-CT-treated patients with FPR > 20. Stage II CRC patients with 20 ≥ FPR > 15 could significantly benefit from postoperative CT, as the recurrence (33.30%) and death (35.71%) rates within non-CT treated patients were approximately five times higher than those of the CT-treated cases (6.77% and 7.41% for the recurrence and death rates, respectively). No significant difference in recurrence rate was observed between L-FPR (≤ 15) patients with (10.00%) or without CT (9.76%), indicating that these patients might not require to receive adjuvant CT after curative resection. Conclusions Preoperative FPR combined with CEA is superior to common tumor biomarkers, FPR, or AFR in distinguishing early-stage CRC from benign colorectal polyps. Circulating FPR can be an effective biomarker for identifying high-risk patients and choosing suitable therapeutics for early-stage CRC.

show abstract

Section: Methodssupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Quantification of fibrinogen-to-pre-albumin ratio provides an integrating parameter for differential diagnosis and risk stratification of early-stage colorectal cancer

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…At present, many prognostic biomarkers are used to evaluate a variety of malignant tumors, such as AFR, fibrinogen-to-prealbumin (FPR), neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. [23][24][25][26] However, the diagnostic value of these markers for Hp-NGC remains unclear. Therefore, this study explored the clinical value of PFR and AFR in the diagnosis of Hp-NGC.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of combined prealbumin-to-fibrinogen and albumin-to-fibrinogen ratios in Hp-negative gastric cancer

Zhang

Qin

et al. 2022

Int J Biol Markers

View full text Add to dashboard Cite

Background This study aimed to investigate the diagnostic value of prealbumin-to-fibrinogen ratio (PFR) and albumin-to-fibrinogen ratio (AFR) alone or in combination in Helicobacter pylori-negative gastric cancer (Hp-NGC) patients. Methods This study included 171 healthy controls, 180 Hp-NGC patients, and 215 Helicobacter pylori-negative chronic gastritis (HpN) patients. We compared the differences of various indicators and pathological characteristics between groups with Mann–Whitney U test and Chi-square test. The diagnostic value of PFR and AFR alone or in combination for Hp-NGC patients was assessed by the receiver operating characteristic (ROC) curve. Results PFR and AFR were related to the progression and clinicopathological characteristics of Hp-NGC. As the disease progressed, PFR and AFR values gradually decreased and were negatively related to the tumor size and depth of invasion. In addition, the area under the curves (AUCs) that resulted from combining PFR and AFR to distinguish Hp-NGC patients from healthy controls and HpN patients were 0.908 and 0.654, respectively. When combined with PFR and AFR in the differential diagnosis of tumors with a maximum diameter ≥ 5 cm and the T3 + T4 stage, the AUCs were 0.949 and 0.922; the sensitivity was 86.32% and 80.74%; and the specificity was 94.74% and 92.98%, respectively. Conclusions PFR and AFR may be used as diagnostic biomarkers for Hp-NGC. The combination of PFR and AFR was more valuable than each indicator alone in the diagnosis of Hp-NGC.

show abstract

“…Based on this concept, inflammation‐based indices are significantly associated with the prognosis of patients with CRC. Such indices include the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), albumin (ALB) to fibrinogen ratio, fibrinogen to prealbumin ratio, modified Glasgow Prognostic Score (mGPS), and C‐reactive protein (CRP) to ALB ratio (CAR) 6–8 …”

Section: Introductionmentioning

confidence: 99%

“…Such indices include the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), albumin (ALB) to fibrinogen ratio, fibrinogen to prealbumin ratio, modified Glasgow Prognostic Score (mGPS), and C-reactive protein (CRP) to ALB ratio (CAR). [6][7][8] Moreover, malnutrition is common in patients with CRC and is associated with intolerance to anticancer treatment and poor prognosis. 9 Cumulative evidence shows that nutritional support can improve the quality of life and survival rate of patients with CRC.…”

mentioning

confidence: 99%

Preoperative C‐reactive protein to prealbumin ratio is independently associated with prognosis in patients with resectable colorectal cancer

Huang

Cai

Zhao

et al. 2022

Journal of Surgical Oncology

View full text Add to dashboard Cite

Background: Increasing attention has been drawn the prognostic value of inflammatory indices for colorectal cancer (CRC). However, the prognostic value of the preoperative C-reactive protein to prealbumin ratio (CPAR) in CRC remains unclear. Methods: A retrospective study was conducted with 794 patients who had CRC and underwent radical surgical resection. The predictive performance of the inflammatory indices was analyzed and compared using the area under the timedependent receiver operating characteristic curve. A competing risk regression model and Cox proportional hazard model were used to analyze the effects of CPAR on disease-free survival (DFS) and overall survival (OS), respectively. Results: Patients with high CPAR (>7.25) had poor survival outcome. The CPAR had the best predictive performance among all inflammatory indices, and was significantly associated with several characteristics of tumor invasion, including histological grade, tumor stage, and tumor size. Multivariate analysis showed that high CPAR was independently associated with poor DFS (subdistribution hazard ratio = 2.28, 95% confidence interval [CI]: 1.74-2.82) and OS (hazard ratio = 1.78, 95% CI: 1.60-1.96). Conclusion:Preoperative CPAR assessment could serve as an effective and reliable tool for prognostic prediction in patients with resectable CRC.colorectal cancer, C-reactive protein to prealbumin ratio, disease-free survival, inflammatory index, overall survival | INTRODUCTIONGlobally, colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer death. 1 There have been great improvements in our understanding of its etiology, risk factor, molecular biology, and clinical aspects over the past decades, but it still accounts for nearly 10% of the global cancer burden, with over 1.9 million new diagnoses and 0.9 million deaths in 2020. 2 Radical surgery is the preferred treatment for patients with resectable CRC, but for patients who undergo radical resection, the prognosis is still poor, with 60% of patients surviving for 5 years. 3 Tumor progression, including recurrence and distant metastasis, remains a major concern for patients after surgery.

show abstract

The value of circulating fibrinogen-to-pre-albumin ratio in predicting survival and benefit from chemotherapy in colorectal cancer

Cited by 14 publications

References 36 publications

Quantification of fibrinogen-to-pre-albumin ratio provides an integrating parameter for differential diagnosis and risk stratification of early-stage colorectal cancer

Quantification of fibrinogen-to-pre-albumin ratio provides an integrating parameter for differential diagnosis and risk stratification of early-stage colorectal cancer

Diagnostic value of combined prealbumin-to-fibrinogen and albumin-to-fibrinogen ratios in Hp-negative gastric cancer

Preoperative C‐reactive protein to prealbumin ratio is independently associated with prognosis in patients with resectable colorectal cancer

Contact Info

Product

Resources

About