The Value of Bronchial Washings and Bronchoalveolar Lavage in the Diagnosis of Lymphangitic Carcinomatosis

Levy, Howard; Hořák, David; Lewis, Michael I.

doi:10.1378/chest.94.5.1028

Cited by 62 publications

(17 citation statements)

References 7 publications

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“…The efficacy of the cytological examination of BALF in primary lung cancer has been proven [6|, especially in bronchioloalveolar carcinoma 17-9 1 and when the interstitium is affected by carcinoma [10], hematological malignancy, leukemia [ 111. non-Hodgkin lymphoma |I2-14], Hodgkin lymphoma [15] and also métastasés into the lungs from adenocarcinoma of the breast [16).…”

Section: Discussionmentioning

confidence: 99%

Bronchoalveolar Lavage in the Diagnosis of Peripheral Primary and Secondary Malignant Lung Tumors

Debeljak¹,

Mermolja²,

Sorli³

et al. 1994

Respiration

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The success rate of cytological examination of the bronchoalveolar lavage fluid (BALF) in patients with primary or metastatic lung tumors varies considerably according to different authors. In a prospective study, we have tried to establish the sensitivity of BAL in comparison with both transbronchial lung biopsy (TBB) and brushing. BAL was performed in 61 patients with lung malignancies and in 56 patients with nonmalignant lung disease: 39 patients had primary lung cancer, 22 had metastatic spread into the lungs. First the part of the lung involved was washed out with 100 ml physiological saline solution during bronchoscopy. Following BAL, 5 TBB and brushing were performed. The smears were stained by the May-Grünwald-Giemsa method. Malignant cells were found in BALF from 17 patients, in TBB specimens from 43 and in brushing smears from 26. TBB was significantly the most successful method applied. Malignant cells were never found in BALF only, nor were they ever found in patients with non-malignant lung disease. The sensitivity of the three methods was equal for primary as compared to metastatic tumors and for interstitial infiltrates as compared to coin lesions. Malignant cells were most frequently found in centrifuged specimens. BAL may be used in suspected malignant interstitial or rounded pulmonary infiltrates when it cannot be reached by forceps or brush, or when TBB and brushing are contra-indicated.

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Section: Discussionmentioning

confidence: 99%

Bronchoalveolar Lavage in the Diagnosis of Peripheral Primary and Secondary Malignant Lung Tumors

Debeljak¹,

Mermolja²,

Sorli³

et al. 1994

Respiration

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“…In the absence of a known primary tumor, the diagnosis requires cellular or tissue confirmation (bronchoalveolar lavage [BAL], pleural fluid collection, transbronchial biopsy, or surgical lung biopsy). (5) Because such tumors are typically distributed among the lymphatics of the bronchovascular bundles, bronchoscopic biopsy is a highly effective diagnostic method (Figure 3). …”

Section: Erdheim-chester Diseasementioning

confidence: 99%

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

et al. 2008

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High-resolution computed tomography (HRCT) is the radiological imaging technique best suited to revealing changes in lung structure. Various HRCT findings, taken together, can represent typical patterns. These patterns, in conjunction with the anatomical distribution of findings and with clinical data, can narrow the differential diagnosis of diffuse interstitial lung disease and, in many cases, indicate the correct diagnosis with a high degree of accuracy. The most common HRCT patterns seen in cases of diffuse interstitial lung diseases are the nodular pattern, linear/reticular opacities, cystic lesions, ground-glass opacities and consolidations. This article reviews the correlations between HRCT patterns and pathologic findings, summarizing the most common causes, as well as detailing the methods of investigation employed in order to diagnose the most common types of chronic diffuse lung disease.Keywords: Lung diseases, interstitial/pathology; Tomography, X-Ray computed; Diagnostic techniques, respiratory system. ResumoA tomografia de alta resolução (TCAR) é a técnica de imagem radiológica que reflete mais de perto as alterações da estrutura pulmonar. Os vários achados tomográficos podem ser combinados para formar padrões típicos. Estes, conjuntamente com a distribuição anatômica dos achados, e com os dados clínicos, podem estreitar o diagnóstico das doenças intersticiais pulmonares difusas, e em vários casos sugerir o diagnóstico correto com alto grau de acurácia. Os padrões mais comuns das doenças intersticiais pulmonares difusas na TCAR são o nodular, linear e reticular, lesões císticas, opacidades em vidro fosco e consolidações. Este artigo revisa as correlações entre os padrões tomográficos na TCAR e os achados patológicos e resume as causas mais comuns e os métodos de investigação para se atingir um diagnóstico nas doenças pulmonares crônicas difusas mais comuns.Descritores: Doenças pulmonares intersticiais/patologia; Tomografia computadorizada por raios X; Técnicas de diagnóstico do sistema respiratório.* Study carried out in the

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“…Bronchoalveolar lavage and washings are described in some reports to yield cytology of approximately 75%. 18 Currently, transbronchial biopsy is considered the initial approach due to patient tolerance and presumed high yield but published sensitivity or specificity is lacking. [19][20][21] Surgical lung biopsy and transthoracic lung biopsy are alternative approaches.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Lymphangitic Carcinomatosis From Renal Cell Carcinoma

Riley

Verma

Mohammed

et al. 2021

Current Problems in Diagnostic Radiology

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The Value of Bronchial Washings and Bronchoalveolar Lavage in the Diagnosis of Lymphangitic Carcinomatosis

Cited by 62 publications

References 7 publications

Bronchoalveolar Lavage in the Diagnosis of Peripheral Primary and Secondary Malignant Lung Tumors

Bronchoalveolar Lavage in the Diagnosis of Peripheral Primary and Secondary Malignant Lung Tumors

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

Pulmonary Lymphangitic Carcinomatosis From Renal Cell Carcinoma

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