The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome

Muasher, Suheil J.; Oehninger, Sergio; Simonetti, Simonetta; Matta, James F.; Ellis, Linda M.; Liu, Hung-Ching; Jones, George Fenwick; Rosenwaks, Zev

doi:10.1016/s0015-0282(16)60077-8

Cited by 294 publications

(97 citation statements)

References 17 publications

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“…All these oocyte donors were recruited in accordance with acceptable ethical principles approved by the Israeli Health Ministry and HTFA (UK). Half of them had given birth in the past, none of them were under going infertility treatment, and all showed a normal ovarian reserve [11], which was assessed by determination of basal cycle day 3 serum FSH, LH and estradiol levels [12]. There is no general agreement on which is the best ovarian stimulation protocol to use in donors with the aim of recovering a cohort of fertilizable oocytes of highest developmental potential while minimizing the risk of ovarian hyperstimulation.…”

Section: Oocytes Donation and Fertilizationmentioning

confidence: 99%

Male age influences oocyte-donor program results

Girsh

Katz

Genkin

et al. 2008

J Assist Reprod Genet

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Background The purpose of our research was to examine the relationship between male age and semen parameters in a range of ages (from 20s to 60s) in Egg Donation Program (EDP) cycles. EDP provides a pool of high quality oocytes, thus allowing better analysis of the sperm efficacy. Discussion The retrospective study population consisted of 484 male partners of patients undergoing EDP in in-vitro fertilization (IVF) treatments. A comparison was made of male age and sperm parameters within two groups: cycles resulting in a pregnancy (pregnant group) and cycles which failed to achieve a pregnancy (non-pregnant group). The men involved in the pregnant group were found to be significantly younger 43.2±8.1 than those of the nonpregnant group 46.8±7.8 (p=0.003). Analysis of sperm morphology revealed a significant prevalence of teratozoospermia in males of the non-pregnant group, as compared to the males of the pregnant group (29% vs. 11%, respectively). The results also demonstrate that sperm parameters are apparently not diminished until men reach the age of 40. However, between 40-50 years old semen parameters deteriorate. Male age was found to be related to a reduction in sperm strict criteria: 44.8 in normozoospermia, 47.9 (p=0.02), 48.4 (p=0.04) and 51.9 (p=0.001) years old in mild teratozoospermia, moderate teratozoospermia and severe teratozoospermia, respectively. Additionally, the results showed that the percentage of "healthy" embryos on day 3 of embryo culture was lower in the non-pregnant group (26%), as compared with the pregnant group (34%; p=0.01). Conclusion Our study confirms that sperm parameters are reduced by age and suggests that this age-dependent effect could be a reason for failures in IVF cycles even in EDP couples.

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Section: Oocytes Donation and Fertilizationmentioning

confidence: 99%

Male age influences oocyte-donor program results

Girsh

Katz

Genkin

et al. 2008

J Assist Reprod Genet

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“…In order to obtain good results it is necessary to assess ovarian reserve before planning treatment. The determination of ovarian reserve by measuring day 3 basal FSH among normal cycling women is one of the most commonly used tests for predicting success in IVF treatment [1]. Several studies have reported that women with an elevated FSH level have poor response to ovarian stimulation that leads to a lower pregnancy rate in ART regardless their age [2].…”

Section: Introductionmentioning

confidence: 99%

Can Elevated Levels of Basal Follicle Stimulating Hormone Predict a Decrease in Fertility in Young Women Undergoing ART Cycles?

Jellad¹

2016

OGIJ

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Background: The determination of ovarian reserve is often measured in normal cycling women through day 3 basal FSH. This determination will help to choose patients who are eligible for starting assisted reproductive technique (ART) cycles. Female age and basal FSH level are independently associated with IVF outcome.Objective: This study aims' at evaluating the impact of basal FSH level associated with female age on IVF outcome. Methods:A retrospective study that included 367 patients undergoing ICSI cycles. Basal FSH levels were measured using the same immunoenzymatic method for all patients. The age of women was checked before they were undergoing pituitary desensitization. Patients were divided into 4 groups according to their age and basal FSH levels. Then its correlation with IVF outcome was evaluated. Results:The increase of FSH levels was associated significantly with reduced oocytes retrieved, and embryos obtained in young women. Nevertheless, there was no significant difference in terms of fertilization or pregnancy rate. Cancellation rates were significantly higher among patients with high day 3 FSH levels compared to patients having normal FSH levels in all age groups. Loss rates were affected by FSH levels among patients < 38 years old. However, they were significantly higher in older patients having elevated day 3 FSH levels. Younger women with high FSH levels produced less but better quality embryos resulting in acceptable pregnancy rate. Conclusion:Female age is the most important prognostic factor. The basal FSH should be used to identify women who are purveyors of poor response to ART and should not be used to exclude them from fertility treatment.

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“…The value of FSH has been mainly tested in IVF populations. Those IVF patients with elevated FSH levels were shown to have lower pregnancy rates (4,5), and the predictive value of FSH was better than age alone (6). pregnancy in IVF patients (7), that age was more predictive for the occurrence of pregnancy after IVF (8), and that moderately elevated FSH levels were not predictive of IVF outcome, especially in younger women (9).…”

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confidence: 97%

High follicle-stimulating hormone levels should not necessarily lead to the exclusion of subfertile patients from treatment

Rooij

Jong

Broekmans

et al. 2004

Fertility and Sterility

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Objective:To determine ongoing pregnancy rates in subfertile patients with elevated FSH levels and regular cycles and to assess whether or not it is justified to exclude such patients from treatment on the basis of elevated FSH levels alone. Result(s):Overall ongoing pregnancy rates declined from 65% in the normal FSH group to 47%, and 28% in the respective elevated FSH groups. However, when adjusting for differences in age and whether or not treatment was applied, this declining trend became inconsistent for both treatment-independent and treatmentdependent ongoing pregnancy rates. Only when FSH levels exceeded 20 IU/L was a clear fall in ongoing pregnancy rate observed, independent of age. In a Cox regression analysis, FSH seemed significantly associated with the outcome time to overall ongoing pregnancy (odds ratio ϭ 0.94, 95% confidence interval, 0.88 -0.99), but after adjusting for age and being on treatment or not this significance disappeared (odds ratio ϭ 0.97, 95% confidence interval, 0.91-1.01). Conclusion(s):The contribution of FSH in the initial evaluation of subfertile couples is restricted to counseling patients on the probability of having lower chances of conceiving. It does not seem justified to exclude patients with normal regular cycles from treatment on the basis of the FSH value alone. (Fertil Steril 2004;81:1478 -85. ©2004 by American Society for Reproductive Medicine.) Key Words: FSH, subfertility, pregnancy, regular cycle With increasing female age, the probability of pregnancy declines (1, 2). This decline in fertility is most probably due to diminishing ovarian reserve, that is, the quantity and quality of the follicles in the ovary (3). However, biological variation exists in the ovarian reserve of women of the same age, and therefore chronological age alone may not give a reliable reflection of ovarian reserve.These observations led to the search for ovarian reserve tests, of which the measurement of FSH in the early follicular phase is the most common one. The value of FSH has been mainly tested in IVF populations. Those IVF patients with elevated FSH levels were shown to have lower pregnancy rates (4, 5), and the predictive value of FSH was better than age alone (6).Recently, some debate about the real clinical value of measuring FSH before IVF has arisen because investigators have found that FSH is of limited value in predicting ongoing

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The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome

Cited by 294 publications

References 17 publications

Male age influences oocyte-donor program results

Male age influences oocyte-donor program results

Can Elevated Levels of Basal Follicle Stimulating Hormone Predict a Decrease in Fertility in Young Women Undergoing ART Cycles?

High follicle-stimulating hormone levels should not necessarily lead to the exclusion of subfertile patients from treatment

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