The value of antithrombin-III and fibronectin in hypertensive disorders of pregnancy

Chen, Sen; Madazh, R; Kavuzlu, C; Ocak,; Tolun, Necati

doi:10.1515/jpme.1994.22.1.29

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…Several authors reported increased plasma levels of fibronectin as a predictor of preeclampsia. 3,28,29 In our current study, the plasma levels of fibronectin in preeclamptic women were significantly higher than those in women with normal pregnancy or chronic hypertension. This supports the potential predictive value of fibronectin as a marker of preeclampsia.…”

Section: Discussioncontrasting

confidence: 41%

Flow-Mediated Vasodilation and Plasma Fibronectin Levels in Preeclampsia

et al. 2000

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Abstract-To clarify the vascular endothelial function in pregnant women with hypertensive disorders, we assessed the flow-mediated vasodilation in the radial artery and compared it with plasma fibronectin levels. We determined flow-mediated vasodilation by measuring the change in radial artery diameter during hyperemia in 58 normal pregnant women, 22 preeclamptic pregnant women, and 15 pregnant women with chronic hypertension. In 41 of the 95 pregnant women, we measured the plasma fibronectin levels. Flow-mediated vasodilation in preeclamptic women was significantly less than that in normal pregnant women (PϽ0.001). In chronic hypertensive women, flow-mediated vasodilation was significantly less than that in normal pregnant women (PϽ0.001) but more than that in preeclamptic women (PϽ0.001). Flow-mediated vasodilation showed significant negative correlation with plasma fibronectin levels (PϽ0. 001, rϭ0.73 Key Words: endothelium Ⅲ vasodilation Ⅲ preeclampsia Ⅲ hypertension, pregnancy Ⅲ fibronectins R ecent evidence suggests that vascular endothelial dysfunction might play an important role in the pathogenesis of preeclampsia. 1,2 There are several suggested methods for assessment of the endothelial damage, including the evaluation of endothelial cell-derived biochemical markers. Endothelium-related serum factors such as cellular fibronectin and the von Willebrand factor have been shown to be abnormal in preeclampsia. [3][4][5] Another method is the assessment of endotheliumdependent vascular relaxing function. An important functional consequence of endothelial dysfunction is the inability to release endothelium-derived relaxing factor (EDRF). 6 EDRF is released in response to various pharmacological and physiological stimuli 7,8 and results in increased blood flow. Under physiological conditions, increased blood flow subsequent to the release from temporal occlusion of the peripheral artery causes vasodilation, which is called reactive hyperemia. 8 With high-resolution ultrasound, it is possible to objectively observe the vascular changes associated with reactive hyperemia. 9 -11 To clarify the endothelial function in pregnancy complicated with hypertensive disorders, we noninvasively assessed the flow-mediated vasodilation in the radial artery with a recently developed 30-MHz mechanical linear probe. Previously, we reported flow-mediated vasodilation in smaller number of pregnant subjects. 12 In our current report, we measured plasma fibronectin level, one of the endothelial cell-injury markers, and determined the relationship between vasodilation and fibronectin level. MethodsWe examined a total of 95 Japanese women, including 58 normal pregnant women, 22 pregnant women with preeclampsia, and 15 pregnant women with chronic hypertension. The diagnosis of preeclampsia and chronic hypertension was established on the basis of the criteria of the Committee on Terminology of the American Collage of Obstetricians and Gynecologists. 13 All the subjects were nonsmokers and received no antihypertensive agents before the...

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Section: Discussioncontrasting

confidence: 41%

Flow-Mediated Vasodilation and Plasma Fibronectin Levels in Preeclampsia

et al. 2000

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“…In the present study increased second trimester plasma levels of fibronectin in patients who later developed preeclampsia has been observed. Fibronectin as a valuable predictor of subsequent preeclampsia has been demonstrated by other investigators [14,23]. Increased plasma fibronectin levels, even before the clinical onset of preeclampsia, confirms the concept of preeclampsia as an endothelial cell dysfunction disease.…”

Section: Discussionmentioning

confidence: 57%

“…Fibronectin is a glycoprotein synthesized in the endothelial cell and its elevated level may be an indicator of endothelial damage. The association of elevated plasma fibronectin in preeclampsia have been documented in previous studies indicating an endothelial cell dysfunction [13,14].…”

Section: Introductionmentioning

confidence: 62%

Prediction of preeclampsia with maternal mid‐trimester placental growth factor, activin A, fibronectin and uterine artery Doppler velocimetry

Madazli

Kuseyrioglu

Uzun

et al. 2005

Intl J Gynecology & Obste

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“…These results were in consistent with the results given by S. Mohapatra et al 16 and Mindora Onisai, AnaMaria Vladareanu, Horia Bumbea et al 17 AT-III is plasma protein which inactivates all activated clotting enzymes, except factor VIIa, and is thought to be main physiologic inhibitor of blood coagulation. 18 It belongs to the class of serine protease inhibitors. 19 Several hypothesis have been suggested for the reduction of AT-III associated with preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Association of antithrombin-III and platelet count with pregnancy induced hypertension

Sarkar

Sogani

2013

Int J Reprod Contracept Obstet Gynecol

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Preeclampsia is referred to as the “disease of the theories” because of the multiple hypotheses proposed to explain its occurrence. Despite considerable research, the causes of preeclampsia remain unclear. It is multifactorial in nature and recent research has focused on the measurements of various prothrombotic markers for detection of latent clotting pathway activation. This study was undertaken to determine the changes in the levels of plasma Antithrombin -III (AT-III) and platelet count in preeclamptic women and its comparison with healthy non-pregnant women and normal pregnant women and its correlation with severity of disease in order to evaluate if it can be used as a marker for severity of pregnancy induced hypertension (PIH). This is the case-control hospital based study carried in the Department of Biochemistry M.G.M. Medical College and associated M.Y. Hospital. Indore (M.P.). 40 women with preeclampsia in the third trimester of pregnancy constituted the study group. The study group was further divided into two subgroups as mild and severe preeclampsia. Age and gestational age matched 23 healthy non –pregnant and 28 normal pregnant women were taken as a control group. There were no significant differences among the three groups in age and body mass index (BMI) but significantly higher differences in gestational age, systolic and diastolic blood pressure was observed. When compared with control groups (healthy non-pregnant and normal pregnant women), the levels of AT-III in preeclamptic group was significantly lower. Although there was no significant difference in the levels of AT-III between healthy non-pregnant and normal pregnant women. The platelet count between healthy non-pregnant and normal pregnant women showed statistically significant difference whereas statistically higher significant difference was observed when comparison was done between healthy non-pregnant women and preeclamptic women and normal pregnant women and preeclamptic women. It was concluded from the study that the reduction of platelet count and AT-III are the main predictors to predict and monitor the severity of the condition. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000): 398-401

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The value of antithrombin-III and fibronectin in hypertensive disorders of pregnancy

Cited by 12 publications

References 24 publications

Flow-Mediated Vasodilation and Plasma Fibronectin Levels in Preeclampsia

Flow-Mediated Vasodilation and Plasma Fibronectin Levels in Preeclampsia

Prediction of preeclampsia with maternal mid‐trimester placental growth factor, activin A, fibronectin and uterine artery Doppler velocimetry

Association of antithrombin-III and platelet count with pregnancy induced hypertension

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