The Value of 68GA-DOTATATE PET/CT in Sinonasal Neuroendocrine Carcinoma Management and Detection of Local and Distant Metastases: Case Study and Review of Literature

Liu, Katherine; Ninan, Sen; Goldrich, David; Filimonov, Andrey; Zeiger, Joshua; Govindaraj, Satish; Iloreta, Alfred Marc

doi:10.1055/s-0040-1702684

Cited by 2 publications

(2 citation statements)

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“…36 Ga-68 DOTATATE PET/CT has been reported to be positive in a case of a right sinonasal SNEC with a T3 vertebral body metastases. 37 Although use of Ga-68 DOTATATE PET/CT for sinonasal SNEC follow-up has not been reported, based on the experience with ENB and other small cell neuroendocrine tumors, it seems feasible that Ga-68 DOTATATE PET/CT would have a significant impact on patient care.…”

Section: Other Tumorsmentioning

confidence: 99%

Doing Great With DOTATATE

Zlochower

Steinklein

2021

Topics in Magnetic Resonance Imaging

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Sinonasal tumors are relatively rare and radiographically challenging to evaluate due to their wide variety of pathologies and imaging features. However, sinonasal tumors possessing somatostatin receptor overexpression have the benefit of utilizing a multimodality anatomic and functional imaging for a more comprehensive evaluation. This is particularly evident with esthesioneuroblastoma, with computed tomography and magnetic resonance imaging defining the anatomic extent of the tumor, whereas somatostatin receptor imaging, particularly with gallium-68 DOTATATE positron emission tomography/computed tomography, is used to assess the presence of metastatic disease for staging purposes as well as in the surveillance for tumor recurrence. In addition, areas which accumulate gallium-68 DOTATATE are potentially amenable to treatment with peptide receptor radionuclide therapy. In this manner, a combined approach of anatomic and functional imaging is critical for optimal imaging evaluation and treatment strategy of patients with sinonasal tumors.

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Section: Other Tumorsmentioning

confidence: 99%

Doing Great With DOTATATE

Zlochower

Steinklein

2021

Topics in Magnetic Resonance Imaging

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“…68Gallium-dotatate (Netspot) is a newer somatostatin analogue that can be used as a PET tracer to successfully identify neuroendocrine tumors (NETs). It has been shown to detect neuroendocrine tumors that traditional imaging failed to identify and offers superior image quality, spatial resolution of small lesions, and diagnostic utility [17]. Lutetium (Lu) 177 dotatate is a radioactive targeted therapy specific to the SSTR2 receptor.…”

Section: Introductionmentioning

confidence: 99%

Updates in management strategies of locally advanced sinonasal malignancy

Yaniv

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review Sinonasal tumors are a rare heterogenous group of pathologies with poor prognosis. In recent years better definition and understanding of histology, molecular classification, biological behavior and advances in therapy have resulted in improved prognosis. The purpose of this review is to give an updated summary of the recent advances in treatment, and where relevant, with references to pathology classifications. Recent findings Recent publications highlight the role of induction chemotherapy and advances in radiotherapy in advanced cancers. In addition, better understanding of genomics and histology specific treatment algorithms has led to more tailored treatment approaches. The role of immunotherapy and targeted therapy are yet to be explored. Summary This review gives an up to date summary of the advances in contemporary management strategies for locally advanced sinonasal malignancies and can serve as a guide for researchers and clinicians.

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The Value of 68GA-DOTATATE PET/CT in Sinonasal Neuroendocrine Carcinoma Management and Detection of Local and Distant Metastases: Case Study and Review of Literature

Cited by 2 publications

References 0 publications

Doing Great With DOTATATE

Doing Great With DOTATATE

Updates in management strategies of locally advanced sinonasal malignancy

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