This study investigated the academic traits and habits that predict individual differences in mind-wandering during lectures, and whether this mind-wandering propensity mediates the associations between academic traits and course outcomes (final grade and situational interest in the material). Undergraduates (N=851) from 10 psychology classes at two U.S. universities responded to thought probes presented during two lectures, one before and one after the first exam; they also indicated sitting in the front, middle, or back third of the classroom. At each probe, students categorized their thought content, such as indicating on-task or task-unrelated thought (TUT). Students completed on-line, academic-trait questionnaires at the beginning of the course and a situational interest questionnaire at the end; instructors reported students’ final course grades. Average TUT rate was 24% but individuals’ rates varied widely (SD=18%). TUT rates also increased substantially from the front to the back of the classroom. Multiple-group analyses (with groups representing 10 classrooms) indicated that: (a) classroom media-multitasking habits, initial interest in the course topic, and everyday propensity for mind-wandering and boredom accounted for unique variance in TUT rate (beyond other academic-trait predictors); (b) TUT rate accounted for unique (modest) variance in course grade and situational interest, and; (c) classroom media multitasking and propensity for mind-wandering and boredom had indirect associations with course grades via TUT rate, and these predictor variables, along with initial interest, also had indirect associations with end-of-term situational interest via TUT rate. Some educationally relevant traits and behaviors predict course outcomes in part because they predict in-class mind-wandering.