The Validity of the Bayley-III and DDST-II in Preterm Infants With Neurodevelopmental Impairment: A Pilot Study

Jeong, Seong Uk; Kim, Ghi Chan; Jeong, Ho Joong; Kim, Dong Kyu; Hong, Yoo Rha; Kim, Hui Dong; Park, Seok Gyo; Sim, Young-Je

doi:10.5535/arm.2017.41.5.851

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…The 1992 revision of the DDST, the DDST-II, has been validated across many populations of children with developmental disabilities and brain injuries. 12 We selected specific items from the DDST-II to represent the range of skills observed in the Aicardi Goutières syndrome population.…”

Section: Discussionmentioning

confidence: 99%

Developmental Outcomes of Aicardi Goutières Syndrome

et al. 2019

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Aicardi Goutières syndrome is a monogenic interferonopathy caused by abnormalities in the intracellular nucleic acid sensing machinery ( TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, or IFIH1). Most individuals affected by Aicardi Goutières syndrome exhibit some degree of neurologic impairment, from spastic paraparesis with relatively preserved cognition to tetraparesis and severe intellectual disability. Because of this heterogeneity, it is important to fully characterize the developmental trajectory in Aicardi Goutières syndrome. To characterize the clinical presentation in Aicardi Goutières syndrome, early features were collected from an international cohort of children (n = 100) with genetically confirmed Aicardi Goutières syndrome. There was a heterogeneous age of onset, with overlapping clusters of presenting symptoms: altered mental status, systemic inflammatory symptoms, and acute neurologic disability. Next, we created genotype-specific developmental milestone acquisition curves. Individuals with microcephaly or TREX1-related Aicardi Goutières syndrome secondary were the most severely affected and less likely to reach milestones, including head control, sitting, and nonspecific mama/dada. Individuals affected by SAMHD1, IFIH1, and ADAR attained the most advanced milestones, with 44% achieving verbal communication and 31% independently ambulating. Retrospective function scales (Gross Motor Function Classification System, Manual Ability Classification System, and Communication Function Classification System) demonstrated that two-thirds of the Aicardi Goutières syndrome population are severely affected. Our results suggest multifactorial influences on developmental trajectory, including a strong contribution from genotype. Further studies are needed to identify the additional factors that influence overall outcomes to better counsel families and to design clinical trials with appropriate clinical endpoints.

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Section: Discussionmentioning

confidence: 99%

Developmental Outcomes of Aicardi Goutières Syndrome

et al. 2019

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“…The DDST-II and K-ASQ may present some difficulties in reflecting special developments in Korean children. Recently studies reported that the detection rate of neurological impairment for the DDST-II was 50.7% in neurological impairment of Korean infants [31], and K-ASQ showed low validity for screening neurodevelopmentally delayed premature infants [9]. To reinforce this point, the K-DST was developed with cultural appropriateness in mind by the Korean Society of Pediatrics in 2014 [12].…”

Section: Discussionmentioning

confidence: 99%

“…However, the usefulness of the K-DST to evaluate developmental delay in preterm children has not been studied. Having a useful developmental screening test for preterm infants is very important for the early diagnosis of developmental delays, as some cases could resolve to almost normal developmental outcomes when early intervention and rehabilitation programs are used [11,31].…”

Section: Discussionmentioning

confidence: 99%

Validity of the Korean Developmental Screening Test for very-low-birth-weight infants

et al. 2019

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Purpose The importance of the neurodevelopmental outcomes of very-low-birth-weight (VLBW) infants has been emphasized as their mortality rate has markedly improved. This study aimed to assess the validity of the Korean Developmental Screening Test (K-DST), a developmental screening tool approved by the Korean Society of Pediatrics, for the timely diagnosis of neurodevelopmental delay in VLBW infants. Methods Subjects included VLBW infants enrolled in the Korean Neonatal Network database between January 2012 and December 2014. The collected data were analyzed for sensitivity, specificity, positive predictive value, and negative predictive value (NPV) in the K-DST compared to those in the Bayley Scales of Infant Development-II for VLBW infants. Results A total of 173 patients were enrolled. Their mean gestational age and mean birth weight were 27.5±2.8 weeks and 980.5±272.1 g, respectively. The frequency of failed psychomotor developmental index (PDI) <85 was similar to that in at least one domain of K-DST <1 standard deviation. Failure in more than one K-DST domain compared with a mental developmental index (MDI) <85 showed a sensitivity and NPV of 73.2% and 75.0%, respectively. Failure in more than one K-DST domain compared with PDI <85 showed a sensitivity and NPV of 60.3% and 71.6%, respectively. Each K-DST domain had a stronger correlation with predicting a failing MDI <85 than a failing PDI <85 ( P <0.05). Conclusion K-DST could be a useful screening tool for predicting mental developmental delay in VLBW infants and referring them for neurodevelopmental assessments.

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“…It is an appropriate screening tool with excellent reliability and validity as well as clinical significance 4,14,15) . The BSID-III can evaluate cognition, language, and motor domains as separate CS, as well as assess developmental level, by subdividing the sections into "receptive language, " "expressive language, " and "fine and gross motor" using SS 3) . Therefore, it avoids problems associated with the lack of standardized scores for cognitive vs. language skills and gross vs. fine motor skills 16) .…”

Section: Discussionmentioning

confidence: 99%

“…For example, a low MDI score could reflect a delay in language or cognitive development, or both. The third edition of the Bayley scales, which was published in 2006 for infants and children aged 1 to 42 months, attempted to overcome these limitations by subdividing the composite scores (CS) of the cognitive, language, and motor domains 2,3) . Thus, scaled scores (SS) can assess receptive/expressive communication and fine/gross motor development.…”

Section: Introductionmentioning

confidence: 99%