2021
DOI: 10.1159/000516837
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The Validity of Brief Phenotyping in Population Biobanks for Psychiatric Genome-Wide Association Studies on the Biobank Scale

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Cited by 10 publications
(6 citation statements)
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“…Yet in contrast to the brief self-reports utilized for phenotyping many health traits in clinical settings (e.g., depressive symptoms), or self-reports of history of speech/language/reading problems, a linguistic trait such as prosodic perception needs to be tested more objectively, disentangled from participants' meta-awareness about these abilities. This is in line with calls for brief, reliable, and scalable tools to enable large-scale GWAS of complex cognitive traits (Coleman, 2021).…”
Section: Introductionsupporting
confidence: 71%
“…Yet in contrast to the brief self-reports utilized for phenotyping many health traits in clinical settings (e.g., depressive symptoms), or self-reports of history of speech/language/reading problems, a linguistic trait such as prosodic perception needs to be tested more objectively, disentangled from participants' meta-awareness about these abilities. This is in line with calls for brief, reliable, and scalable tools to enable large-scale GWAS of complex cognitive traits (Coleman, 2021).…”
Section: Introductionsupporting
confidence: 71%
“…The MHQ‐factor in this study was derived from online MHQ items collected by the UKB and they were not clinical diagnoses. While it might not be adequate to represent the general dimension of psychiatric disorders, it can be interpreted as a measurement of general mental health that is potentially more informative than binary case–control distinctions (Coleman, 2021 ). We acknowledge that p‐factor derived from factor modelling is less well validated as in other measures, for example, the g‐factor, and results should be considered accordingly (Cervin et al, 2020 ; van Bork et al, 2017 ; Watts et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…The MHQ-factor in this study was derived from online MHQ items collected by the UKB and they were not clinical diagnoses. While it might not be adequate to represent the general dimension of psychiatric disorders, it can be interpreted as a measurement of general mental health that is potentially more informative than binary case control distinctions (Coleman, 2021). We acknowledge that p -factor derived from factor modelling is less well validated as in other measures, for example the g -factor, and results should be considered accordingly (Cervin et al, 2020; van Bork et al, 2017; Watts et al, 2020).…”
Section: Discussionmentioning
confidence: 99%