The Validity of Bioelectrical Impedance Models in Clinical Populations

Buchholz, Annick; Bartok, Cynthia; Schoeller, Dale A.

doi:10.1177/0115426504019005433

Cited by 187 publications

(169 citation statements)

References 92 publications

(152 reference statements)

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“…We used single-frequency BIA to evaluate some basic electrical properties of the body. BI-index, which is related to the water content of tissues (Buchholz et al, 2004), just changed in parallel with body weight. On the other hand, more interesting results emerged for phase angle.…”

Section: Discussionmentioning

confidence: 99%

Bioelectrical impedance phase angle in constitutionally lean females, ballet dancers and patients with anorexia nervosa

et al. 2008

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Background/objective: Several articles have described body composition in anorexia nervosa, whereas little is known about this issue in underweight ballet dancers and constitutionally lean females. The main aim of this study was to assess whether phase angle (a bioimpedance variable related to body cell mass) differs according to the type of underweight in female adolescents and young women. Subjects/methods: Skinfold thicknesses and bioimpedance analysis (whole body and limbs) were evaluated in three groups of underweight patients (30 patients with anorexia nervosa, 10 constitutionally lean individuals and 15 classical dancers) and 30 normal weight controls. Results: There were no differences between the three groups of underweight patients with respect to anthropometric and bioelectrical impedance analysis (BIA) variables with the exception of phase angle. The latter was significantly higher in dancers, lower in anorectic patients and not different in constitutionally lean patients, as compared with controls. Conclusions: Phase angle (assessed by single-frequency BIA) appears to discriminate between different forms of underweight, being an effective marker of qualitative changes in body composition.

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Section: Discussionmentioning

confidence: 99%

Bioelectrical impedance phase angle in constitutionally lean females, ballet dancers and patients with anorexia nervosa

et al. 2008

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“…Further, we compared pectoralis muscle area with fat-free mass as measured by BIA. Measurement of fat-free mass by BIA is an indirect method of body composition and is not recommended in the clinical setting (30). However, body composition as assessed by BIA has been related to COPD-related traits and outcomes, including mortality, indicating that the method has use in the research setting (15,18,27,30).…”

Section: Original Researchmentioning

confidence: 99%

Quantitative Computed Tomography Measures of Pectoralis Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease. A Cross-Sectional Study

et al. 2014

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Rationale: Muscle wasting in chronic obstructive pulmonary disease (COPD) is associated with a poor prognosis and is not readily assessed by measures of body mass index (BMI). BMI does not discriminate between relative proportions of adipose tissue and lean muscle and may be insensitive to early pathologic changes in body composition. Computed tomography (CT)-based assessments of the pectoralis muscles may provide insight into the clinical significance of skeletal muscles in smokers.Objectives: We hypothesized that objective assessment of the pectoralis muscle area on chest CT scans provides information that is clinically relevant and independent of BMI.Methods: Data from the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) Study (n = 73) were used to assess the relationship between pectoralis muscle area and fat-free mass. We then used data in a subset (n = 966) of a larger cohort, the COPDGene (COPD Genetic Epidemiology) Study, to explore the relationship between pectoralis muscle area and COPD-related traits. Measurements and Main Results:We first investigated the correlation between pectoralis muscle area and fat-free mass, using data from a subset of participants in the ECLIPSE Study. We then further investigated pectoralis muscle area in COPDGene Study participants and found that higher pectoralis muscle area values were associated with greater height, male sex, and younger age. On subsequent clinical correlation, compared with BMI, pectoralis muscle area was more significantly associated with COPD-related traits, including spirometric measures, dyspnea, and 6-minute-walk distance (6MWD). For example, on average, each 10-cm 2 increase in pectoralis muscle area was associated with a 0.8-unit decrease in the BODE (Body mass index, Obstruction, Dyspnea, Exercise) index (95% confidence interval, -1.0 to -0.6; P , 0.001). Furthermore, statistically significant associations between pectoralis muscle area and COPD-related traits remained even after adjustment for BMI.Conclusions: CT-derived pectoralis muscle area provides relevant indices of COPD morbidity that may be more predictive of important COPD-related traits than BMI. However, the relationship with clinically relevant outcomes such as hospitalization and death requires additional investigation. Pectoralis muscle area is a convenient measure that can be collected in the clinical setting in addition to BMI.

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“…Bioelectrical impedance analysis (BIA) using the ImpediMed Imp ™ SFB7, (ImpediMed Ltd., Eight Mile Plains, QLD, Australia) was applied to measure body composition (more information about the device, ImpediMed Imp ™ SFB7 can be found on the website; https://www.impedimed.com/wp-content/products/SFB7/SFB7_CA_Brochure.pdf). ImpediMed Imp ™ SFB7, which has a single channel tetrapolar configuration with a touch screen, is an objective tool used to measure FM, FFM, ICW, ECW, and PA,14, 15, 16, 17 and is a reproducible, noninvasive, and validated device in patients with cancer 17…”

Section: Methodsmentioning

confidence: 99%

Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study

Yoon

Grundmann

Williams³

et al. 2018

Cancer Medicine

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Few studies have examined the possibility that cachexia may affect men and women differently. This pilot study assessed gender differences in body composition in stomach, colorectal, and biliary cancer patients with cachexia. A sample of 38 participants (Female: Male = 17:21, mean age 57.4 years) were included if they were undergoing chemotherapy and experienced weight loss of 5% or more over a 6‐month period. Bioelectrical impedance analysis (BIA) was applied to measure body composition. Phase angle (PA) and levels of extra‐/intracellular water (ECW; ICW) were determined. Data were analyzed first by gender and then compared to age‐ and gender‐matched healthy controls from the NHANES‐III dataset. PA was lower (P < .01) in both genders compared with healthy controls, and PA was lower in female patients compared with male patients (P = .03). Male cancer patients with lower PA also had lower ICW levels compared with healthy controls (r = .98, P < .01). For female patients, PA and ICW were negatively correlated (r = .897, P < .01). A lower ECW/ICW ratio was highly correlated (r = .969 for men, r = .639 for women) with increased PA in cancer patients. ICW changes are gender‐specific in patients with GI cancer. ECW/ICW ratios and PA may be suitable surrogate markers for gender‐specific changes in cell composition and health status.

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The Validity of Bioelectrical Impedance Models in Clinical Populations

Cited by 187 publications

References 92 publications

Bioelectrical impedance phase angle in constitutionally lean females, ballet dancers and patients with anorexia nervosa

Bioelectrical impedance phase angle in constitutionally lean females, ballet dancers and patients with anorexia nervosa

Quantitative Computed Tomography Measures of Pectoralis Muscle Area and Disease Severity in Chronic Obstructive Pulmonary Disease. A Cross-Sectional Study

Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study

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