The Validity of a Smaller Time Frame in the Measurement of Olimpic and World Champions Basal Metabolic Rate

Adrenergic Modulation with Photochromic Ligands

“…Since the adrenergic system is am ajor regulator of the vascular tone,w ec haracterized the adrenergic effects of our compounds by measuring their vascular activity in ex vivo rat aortic rings. [24][25][26] Besides being generally recognized as apotent central hypotensive agent, [27] clonidine is also known to induce vasodilation by acting directly on vascular adrenoceptors. [25] This peripheral response involves stimulation of endothelial a 2 -ARs as well as partial agonism towards a 1 -ARs of the vascular smooth muscle,a nd results in relaxation of endothelium-intact strips previously contracted with phenylephrine (PE).…”

“…[24][25][26] Besides being generally recognized as apotent central hypotensive agent, [27] clonidine is also known to induce vasodilation by acting directly on vascular adrenoceptors. [25] This peripheral response involves stimulation of endothelial a 2 -ARs as well as partial agonism towards a 1 -ARs of the vascular smooth muscle,a nd results in relaxation of endothelium-intact strips previously contracted with phenylephrine (PE). [26,[28][29][30] When testing if our analogues displayed as imilar behaviour,w eo bserved that exposure to UV light alone could induce relaxation of the vascular smooth muscle, substantially abolishing the contraction evoked by PE.…”