The validity and reliability of a Thai version of the Angioedema Control Test: Which recall period is preferable?

Chularojanamontri, Leena; Kulthanan, Kanokvalai; Tuchinda, Papapit; Rujitharanawong, Chuda; Munprom, Kanyalak; Pochanapan, Oraya; Panjapakkul, Waratchaya; Maurer, Marcus; Weller, Karsten

doi:10.12932/ap-270822-1442

Cited by 1 publication

(10 citation statements)

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“…10,21 The current study showed that the Turkish AECT versions were reliable tools with excellent internal consistency and reproducibility in line with the other versions. 10,21 We observed a good level of screening accuracy in concordance with the original and Thai versions. 10,21 In the original study, it was found that equal or greater than 10 points showed well-controlled disease with 75.5% and 81.8% sensitivity and 83.9% and 91.7% specificity for the AECT-4wk and -3mth, respectively.…”

Section: Discussionsupporting

confidence: 70%

“…10 In the Thai study, the cut-off point to determine well-controlled disease was similarly equal or more than 10 points with 97.2% and 82.8% sensitivity and 88.9% and 77.8% specificity for the AECT-4wk and -3mth, respectively. 21 We also observed that the best cut-off point seemed to be 10 with 71.1% and 85% sensitivity and 81.8% and 65.5% specificity for the AECT-4wk and -3mth, respectively.…”

Section: Discussionsupporting

confidence: 54%

“… 10 In the Thai version, similar to our study, a good level of correlation with AE‐QoL, AAS‐28 day and numeric control scales was reported. 21 Also, the Turkish AECT‐4wk and ‐3mth had a high known‐groups validity level, indicating that AECT can discriminate patients with various disease states in concordance with the original and Thai versions. 10 , 21 The current study showed that the Turkish AECT versions were reliable tools with excellent internal consistency and reproducibility in line with the other versions.…”

Section: Discussionmentioning

confidence: 83%

“… 21 Also, the Turkish AECT‐4wk and ‐3mth had a high known‐groups validity level, indicating that AECT can discriminate patients with various disease states in concordance with the original and Thai versions. 10 , 21 The current study showed that the Turkish AECT versions were reliable tools with excellent internal consistency and reproducibility in line with the other versions. 10 , 21 …”

Section: Discussionmentioning

confidence: 83%

“…However, the other authors in Thai versions reported that AECT-4wk may be preferable to the AECT-3mth. 21 As a limitation, we could not determine the impact of AECT on the deterioration of the disease control since we did not have enough patients with deterioration in disease control. Furthermore, we did not include other types of RAE such as idiopathic or acquired AE because they are rarely seen compared to HAE and MMAE and we anticipated that we could not obtain enough data during the study period to compare other groups.…”

Section: Discussionmentioning

confidence: 99%

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Monitoring recurrent angioedema: Findings from the Turkish angioedema control test validation study

Demir,

Eyice‐Karabacak,

Kocatürk

et al. 2024

Clinical & Translational All

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BackgroundDetermination of control level in recurrent angioedema (RAE) is necessary to guide management. Here, we validated a Turkish version of the angioedema control test (AECT) for 4‐week (AECT‐4wk) and for 3‐month (AECT‐3mth) and assessed their utility in monitoring RAE.MethodThe recommended structured translation process for patient‐reported outcome measures was completed. The final versions were administered to 51 patients with mast cell‐mediated angioedema (MMAE) and 38 patients with hereditary angioedema, and the minimal clinically important difference (MCID) was determined. Additionally, anchor surveys comprising angioedema activity score for 28 days (AAS‐28 day), visual analog score for angioedema control, Likert scale for the control level from the patient's perspective (LS‐AEC), angioedema quality of life, short form‐12 (SF‐12) and patients' assessment of treatment sufficiency were applied.ResultsThe Turkish AECT versions showed good convergent validity with a substantial correlation with anchor tools and known‐group validity. Excellent internal consistency and reproducibility were observed. Equal or more than 10 of 16 points scored with the AECT‐4wk and AECT‐3mth identified patients with well‐controlled disease. The disease activity, control and burden parameters were consistent with the disease control level defined depending on the cut‐off point 10 of AECT. Three‐point changes in AECT‐4wk and ‐3 mt could detect MCID in disease control in all patients.ConclusionsTurkish AECT versions are valid and reliable tools for assessing and monitoring disease control in patients with RAE. The use of the Turkish versions of the AECT in routine patient care, clinical trials and angioedema research is recommended.

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