The validation of volumetric real-time 3-dimensional echocardiography for the determination of left ventricular function

Mondelli, John A.; Luzio, Silvia Di; Nagaraj, Ashwin; Kane, Bonnie J.; Smulevitz, Beverly; Nagaraj, Alakananda V.; Greene, R. R.; McPherson, David D.; Rigolin, Vera H.

doi:10.1067/mje.2001.115770

Cited by 41 publications

(16 citation statements)

References 16 publications

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“…Previous studies of volumetric and reconstructed 3DE (3)(4)(5) have shown that this technique shows higher reproducibility than 2DE. In particular, the use of a three-dimensional dataset is the most important aspect of minimizing variation, irrespective of the technique (echocardiography or MRI) (13).…”

Section: Discussionmentioning

confidence: 99%

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Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography

Jenkins

Bricknell

Hanekom

et al. 2004

Journal of the American College of Cardiology

540

324

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Section: Discussionmentioning

confidence: 99%

“…However, although twodimensional echocardiography (2DE) is widely available for LV assessment, it has limited test-retest reliability (3,4). Repeated EF measurements may differ because of poor image quality, geometric issues related to volume calculations, and the performance of off-axis cuts and variations in ventricular loading (5).…”

mentioning

confidence: 99%

Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography

Jenkins

Bricknell

Hanekom

et al. 2004

Journal of the American College of Cardiology

540

324

View full text Add to dashboard Cite

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“…MUGA was chosen as the method of reference, because it remains a generally accepted standard against which other LVEF measurement techniques are evaluated (24)(25)(26), and the method has been shown to be as good as MR imaging (27). Twenty-eight patients were included in the study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Left Ventricular Ejection Fraction with Gated IQ-SPECT Myocardial Perfusion Imaging

Joergensen

Hansson

2015

J. Nucl. Med. Technol.

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The aim of this study was to evaluate the assessment of the left ventricular ejection fraction (LVEF) in patients by gated IQ-SPECT. Methods: Twenty-eight patients were examined using gated 99m Tc-sestamibi IQ-SPECT. Two different reconstruction datasets were created using the same projection data. The number of iterations, subsets, and gaussian filtering were based on 2 different recommendations from the manufacturer. For each dataset, end diastolic volume, end systolic volume, and LVEF were calculated using 4DMSPECT. A multigated planar equilibrium radionuclide ventriculography (MUGA) study with 99m Tc-labeled red blood cells was used as a reference for the LVEF. Results: The values of the different datasets were tested using the Bland-Altman analysis method. The calculated mean and 95% limits of agreement for the LVEF when dataset 1 and 2 were compared were −1.1% and ±15% points; when dataset 1 was compared with MUGA, the mean was calculated to −3.1% points and ±17% points for the 95% limits of agreement. When dataset 2 and MUGA were compared, the mean was −4.2% and 95% limits of agreement of ±18% points. Conclusion: Neither of the gated reconstructed datasets analyzed with 4DMSPECT was comparable to LVEF estimated by MUGA, with a tendency to overestimate LVEF. However, large random variations of the end diastolic volume, end systolic volume, and LVEF between the 2 gated reconstructed datasets were found. The reconstructed datasets were not interchangeable. Thus, these values should only be used with great caution when evaluating the functional state of the heart. Key Words: ejection fraction; IQ-SPECT; gated blood pool; myocardial perfusion imaging J Nucl Med Technol 2015; 43:193-200 DOI: 10.2967/jnmt.115.155382 As a diagnostic technique in coronary artery disease, electrocardiography (ECG)-gated SPECT (gSPECT) data acquisition is an established method. Reconstruction and analysis of the data provide information of left ventricular perfusion, wall motion, wall thickness, and quantification of parameters as left ventricular end diastolic and systolic volumes (EDV and ESV, respectively) and ejection fraction (LVEF). The study is normally performed using dual-or triple-head g-camera systems with low-energy all-purpose or low-energy high-resolution (LEHR) collimators installed and with a 90°or L detector configuration (1). To generate adequate imaging statistics, the overall acquisition time can be 20-30 min. Developments in hardware and software continue improving gSPECT image quality (2,3). In December 2008, Siemens Healthcare announced the Food and Drug Administration clearance of their newly developed hardware and software package called IQ-SPECT, with the purpose of shortening the acquisition time considerably. The Siemens IQ-SPECT system consists of SMARTZOOM collimators (magnifying collimators with a complex design), gantry movement control, and special reconstruction software. SMARTZOOM collimators center on the heart, collecting up to 4 times more counts than LEHR collimators. These collimators magn...

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“…LV hypertrophy is common in patients with renal disease and correlates with the degree of renal functional impairment (27). Although two-dimensional echocardiography is widely utilized for LV mass assessment, it has limited reproducibility (28,29).…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Volume and Adverse Cardiovascular Outcomes in Unselected Patients with and without CKD

Hee

Nguyen

Whatmough

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Patients with CKD have increased cardiovascular morbidity and mortality. This study investigated the prognostic value of common clinical echocardiographic parameters.Design, setting, participants, & measurements There were 289 unselected consecutive patients who had a transthoracic echocardiogram between January and June 2003. Patients with stage 3 or 4 CKD (n=49) were compared with those with eGFR$60 ml/min per 1.73 m 2 , n=240). Left ventricular volume, ejection fraction and mass, left atrial volume, and function parameters were measured. The primary endpoint, determined a priori, was a composite of cardiac death, myocardial infarction, and congestive cardiac failure.Results Patients were followed for a median 5.6 years. The incidence of the primary endpoint was higher in patients with CKD (29% versus 12%, P=0.001), who were older and had a higher prevalence of hypertension and ischemic heart disease. Indexed left ventricular mass (LVMI) and left atrial volume (LAVI) were higher in patients with CKD. Furthermore, patients with LAVI.32 ml/m 2 had significantly lower event-free survival than patients with normal (,28 ml/m 2 ) or mildly dilated LAVI (28-32 ml/m 2 ) (P,0.001). Multivariate analysis showed that age (odds ratio [OR], 1.19; 95% confidence interval [95% CI], 1.08 to 1.31; P=0.001) and LVMI (OR, 3.66; 95% CI, 2.47 to 5.41; P,0.001) were independently associated with LAVI.32 ml/m 2 . Multivariate Cox regression analysis demonstrated that CKD (hazard ratio [HR], 1.13; 95% CI, 1.01 to 1.26; P=0.04), hypertension (HR, 2.18; 95% CI, 1.05 to 4.54; P=0.04), and a larger LAVI (HR, 1.35; 95% CI, 1.02 to 1.77; P=0.04) were independent predictors of the primary endpoint.Conclusions Patients with CKD were at higher risk for cardiovascular events. LAVI was significantly larger in the CKD group and was a predictor of adverse cardiac events.

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The validation of volumetric real-time 3-dimensional echocardiography for the determination of left ventricular function

Cited by 41 publications

References 16 publications

Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography

Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real-time three-dimensional echocardiography

Evaluation of the Left Ventricular Ejection Fraction with Gated IQ-SPECT Myocardial Perfusion Imaging

Left Atrial Volume and Adverse Cardiovascular Outcomes in Unselected Patients with and without CKD

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