The Validation and Use of In Vitro Teratogenicity Tests

Screening Methods for Agent Compatibility with People, Materials, and the Environment

“…For example, if in the literature search, it was noted that some members of the chemical class of interest elicit effects in the liver, then an in vitro method that tests the potential of a chemical to produce liver toxicity would then have a higher priority than, for example, a method to test myocardial arrythmogenic potential. 189, 190, 191, 192, 193, 194, 195, 196 197, 198, 199, 200, 201, 202, 203 Acute Lethality 204,205,206,207,208,209,210,211,212,213 One of the major challenges with in vitro techniques is that the mechanism of action contributing to the endpoint of interest must be understood (12). In the least, knowledge of the target organ is necessary to design a more robust in vitro assay (214).…”