The validation and reproducibility of the pulmonary embolism severity index

Chan, Chee‐Ming; Woods, Christian; Shorr, Andrew F.

doi:10.1111/j.1538-7836.2010.03888.x

Cited by 123 publications

(106 citation statements)

References 15 publications

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“…[6][7][8][9][10] Pulmonary embolism severity index (PESI) is a powerful predictor of worse prognosis, and clinical use of PESI is recommended by the European Society of Cardiology. 7,11,12 CHADS 2 and CHA 2 DS 2 -VASc scores have been widely used in patients with atrial fibrillation (AF) for the prediction of risk of thromboembolic events and also for the management of anticoagulant therapies. 13,14 Higher CHA 2 DS 2 -VASc scores have been shown to be correlated with a higher risk of APE in patients with AF.…”

Section: Introductionmentioning

confidence: 99%

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Onuk

Karataş

İpek

et al. 2016

Clin Appl Thromb Hemost

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Background: CHA 2 DS 2 -VASc score has been validated in risk prediction for stroke and thromboembolism in patients with atrial fibrillation (AF). Association of CHA 2 DS 2 -VASc score with higher risk of venous thromboembolism and pulmonary embolism (PE) has also been shown. In this study, we investigated the long-term prognostic value of CHA 2 DS 2 -VASc score in patients with acute pulmonary embolism (APE). Methods: Consecutive patients with APE presenting to our emergency department were retrospectively recruited. Patients with AF and who died secondary to causes other than PE were excluded from the study. The CHA 2 DS 2 -VASc score and pulmonary embolism severity index (PESI) were calculated. Results: Two hundred seventy seven participants were included in the study. The mortality rate was 18.7%. Twenty-two cases died within 30 days, and 30 cases died during the follow-up period (median: 13 months). The mean CHA 2 DS 2 -VASc score was significantly higher in dead patients compared to survivors (3.61 + 1.35 vs 1.95 + 1.52, P < .01). In multivariate regression analysis, systolic pulmonary artery pressure (hazard ratio [HR]: 1.03, 95% confidence interval [CI]: 1.01-1.06, P ¼ .02), PESI score (HR: 1.010, 95% CI: 1.004-1.017, P < .01), and CHA 2 DS 2 -VASc score (HR: 1.67, 95% CI: 1.19-2.16, P < .01) were found to be independently correlated with mortality. The patients whose CHA 2 DS 2 -VASc score was between 1 and 3 had 5.67 times and patients whose CHA 2 DS 2 -VASc score was 4 had 16.8 times higher risk of mortality compared to patients with CHA 2 DS 2 -VASc score ¼ 0. Conclusion: Patients with higher CHA 2 DS 2 -VASc scores had higher rates of mortality after APE.

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Section: Introductionmentioning

confidence: 99%

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Onuk

Karataş

İpek

et al. 2016

Clin Appl Thromb Hemost

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“…Among these, the PESI or sPESI is the best validated (17,18). Patients at low risk of serious complications according to the scoring system are accepted to be suitable for treatment without hospitalization (4,17).…”

Section: Discussionmentioning

confidence: 99%

A cost comparison of warfarin vs enoxaparine or new oral anticoagulants used for the treatment of patients with pulmonary embolism

Türk

Aldağ²,

Oğuzülgen³

et al. 2016

Tuberk Toraks

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“…Среди них индекс тяжести ТЭЛА (Pulmonary Embolism Severity Index -PESI) (табл. 8) является наиболее распространенной валидизиро ванной шкалой [211][212][213][214]. В исследовании [215] при помощи индекса PESI наилучшим образом выявля лись больные с неблагоприятным 30 дневным исхо дом, чем при использовании традиционной Женев ской прогностической шкалы [216].…”

Section: прогностическая оценка клинические параметрыunclassified

Pulmonary embolism: clinical guidelines of European Society of Cardiology (2014).The Task Force of the European Society of Cardiology for diagnosis and management of pulmonary embolism

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2015

Pulʹmonologiâ (Mosk.)

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РезюмеВ данных Клинических рекомендациях суммированы все современные доказательства по диагностике и лечению тромбоэмболии легочной артерии (ТЭЛА). В отличие от предыдущей версии рекомендаций, в данном документе представлены упрощенные варианты клинических прогностических шкал, подробно рассмотрена стратификация риска летального исхода, включая промежуточные степени риска, представлены новые подходы к АКТ, в т. ч. системному тромболизису и катетерным методам лечения, терапии антагонистом витамина К, определено место новых пероральных антикоагулянтов в терапии ТЭЛА. Ключевые слова: рекомендации, тромбоэмболия легочной артерии, венозный тромбоз, шок, гипотензия, торакалгия, одышка, сердеч ная недостаточность, диагностика, антикоагулянты, тромболизис. SummaryThese clinical recommendations summarized currently available evidence on diagnosis and management of patients with pulmonary embolism. When compared to previous version of recommendations, this document has introduced simplified clinical prognostic scales and a new risk stratifi cation system including intermediate risk. Novel approach to anticoagulant therapy have been also reviewed including systemic thrombolysis, catheter directed treatment, vitamin K antagonists and new oral anticoagulants. Key words: recommendations, pulmonary embolism, venous thromboembolism, shock, hypotension, chest pain, dyspnea, heart failure, diagnosis, anticoagulants, thrombolysis.Тромбоэмболия легочной артерии: клинические рекомендации Европейского общества кардиологов (2014) 526Пульмонология. 2015; 25 (5): 525-552 возникавших в ходе работы над Рекомендациями, надлежало информировать ЕОК и вносить соответ ствующие поправки. Финансирование Рабочей груп пы проводилось за счет средств ЕОК полностью, без участия представителей медицинской промышлен ности.Комитетом ЕОК по Практическим рекомендаци ям проведены наблюдение за процессом подготовки новых Клинических рекомендаций и его координа ция. Члены Комитета также несли ответственность за утверждение новых Клинических рекомендаций. Клинические рекомендации ЕОК активно проана лизированы Комитетом по Практическим рекомен дациям и внешними экспертами. После соответст вующих поправок Рекомендации были одобрены всеми экспертами Рабочей группы. Окончательный документ был утвержден Комитетом по Практичес ким рекомендациям для публикации в журнале European Heart Journal.Задача написания Клинических рекомендаций ЕОК заключается не только в объединении результа тов исследований последних лет, но также и в разра ботке образовательных методик и программ внедре ния Рекомендаций в практическое здравоохранение.Для практического использования Рекоменда ций готовится их краткая («карманная») версия, а также слайды, буклеты с ключевыми положения ми, листовки для неспециалистов и электронная версия для смартфонов и других гаджетов (сокра щенные варианты); с полным текст Рекомендаций опубликован на сайте ЕОК и находится в свободном доступе. Национальным обществам рекомендуется утверждать, переводить на национальные языки и внедрять Клинические рекоме...

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The validation and reproducibility of the pulmonary embolism severity index

Abstract: The PESI correlates with 30- and 90-day mortality. It represents a reproducible scoring tool to risk stratify patients with acute PE.

Cited by 123 publications

References 15 publications

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

A cost comparison of warfarin vs enoxaparine or new oral anticoagulants used for the treatment of patients with pulmonary embolism

Pulmonary embolism: clinical guidelines of European Society of Cardiology (2014).The Task Force of the European Society of Cardiology for diagnosis and management of pulmonary embolism

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The validation and reproducibility of the pulmonary embolism severity index

Abstract: The PESI correlates with 30- and 90-day mortality. It represents a reproducible scoring tool to risk stratify patients with acute PE.

Cited by 123 publications

References 15 publications

Higher CHA2DS2-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Higher CHA2DS2-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

A cost comparison of warfarin vs enoxaparine or new oral anticoagulants used for the treatment of patients with pulmonary embolism

Pulmonary embolism: clinical guidelines of European Society of Cardiology (2014).The Task Force of the European Society of Cardiology for diagnosis and management of pulmonary embolism

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Product

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Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism