The vagus, the bile, and gallstones.

Bouchier, I. A. D.

doi:10.1136/gut.11.9.799

Cited by 17 publications

(3 citation statements)

References 36 publications

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“…Neither bile salt excretion nor bile salt-independent fractions were changed. The results do not necessarily exclude long-term D ebray/ de la Tour/R ozé/Souchard/V aille biliary effects of vagotomy in the rat, as was shown in other species [1,13,15,20] including man [4]. Large doses of antimuscarinic drugs, hyoscyamine and atropine [10] did not decrease but increased bile flow in the rat.…”

Section: Discussionmentioning

confidence: 95%

Independence from Vagal Control of Biliary Secretion in the Rat

Debray¹,

Tour²,

Rozé³

et al. 1974

Digestion

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The effects on bile secretion of classical stimulants and depressants of the parasympathic system were reinvestigated in the anaesthetized rat. Antimuscarinic drugs and vagotomy did not decrease bile flow; acetylcholine and 2-deoxy-D-glucose did not increase bile flow; insulin-induced increase in bile flow was not suppressed by vagotomy. These results do not support the hypothesis of a short-term vagal control of biliary secretion in the anaesthetized rat.

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Section: Discussionmentioning

confidence: 95%

Independence from Vagal Control of Biliary Secretion in the Rat

Debray¹,

Tour²,

Rozé³

et al. 1974

Digestion

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“…The vagus may influence gall-bladder muscle directly by a specific motor effect, which may be important in maintaining muscle tone, or indirectly by sensitising the gall-bladder to cholecystokinin and thus influencing contraction (Bouchier, 1970).…”

Section: Discussionmentioning

confidence: 99%

“…1947;Griffiths and Holmes, 1964;Lundman et al, 1964) and a number of reports specifically suggest that truncal vagotomy may be implicated in gallstone formation (Neilson, 1964;Nobles, 1966;Clave and Caspar, 1969;Tompkins et al, 1972). The validity of these observations has, however, been questioned ( Turunen and Antila, 1964;Mujahed and Evans, 1971;Costello, 1970) and in the absence of a well-controlled prospective clinical trial the relationship remains 'unproven' (Fletcher and Clark, 1968;Bouchier, 1970).…”

mentioning

confidence: 99%

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

McMaster¹,

Medd²,

McLeish³

1979

Eur Surg Res

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An increased incidence of gallstones has been reported following truncal vagotomy and gastric drainage but never conclusively proven. In the Rhesus monkey, bile composition and flow is similar to man. A model of biliary drainage was established which permits continuous monitoring of bile kinetics. Following truncal vagotomy and pyloroplasty, a significant fall in bile acid concentration was observed, accompanied by a rise in cholesterol concentration. This resulted in an overall rise in cholesterol saturation. Similar changes in hepatic bile composition were, however, also seen following pyloroplasty alone, and suggests that the vagotomy itself may not be the important factor in producing bile changes.

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Cholelithiasis after Vagotomy

Becker¹,

Caspary²

1980

Postgastrectomy and Postvagotomy Syndromes

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The vagus, the bile, and gallstones.

Cited by 17 publications

References 36 publications

Independence from Vagal Control of Biliary Secretion in the Rat

Independence from Vagal Control of Biliary Secretion in the Rat

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

Cholelithiasis after Vagotomy

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