The Vagus Nerve: A Tonic Inhibitory Influence Associated With Inflammatory Bowel Disease in a Murine Model

Ghia, Jean–Eric; Blennerhassett, Patricia; Kumar-Ondiveeran, Harry; Verdú, Elena F.; Collins, Stephen M.

doi:10.1053/j.gastro.2006.08.016

Cited by 344 publications

(334 citation statements)

References 45 publications

(53 reference statements)

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“…Disease activity index (DAI) is a combined score of weight loss, stool consistency, and fecal bleeding, and was blindly assessed using a previously published scoring system (40). This scoring system was defined as follows: weight loss: 0 = no loss, 1 = 1-5%, 2 = 5-10%, 3 = 10-20%, 4 = 20%+; stool: 0 = normal, 2 = loose stool, 4 = diarrhea; and bleeding: 0 = no blood, 2 = Hemoccult positive (Hemoccult II; Beckman Coulter, Fullerton, CA), and 4 = gross blood (blood around anus).…”

Section: Assessment Of Colitis Severitymentioning

confidence: 99%

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Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation

Kim

Bridle

Ghia

et al. 2013

The Journal of Immunology

106

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Mucosal inflammation in conditions ranging from infective acute enteritis or colitis to inflammatory bowel disease is accompanied by alteration in serotonin (5-hydroxytryptamine [5-HT]) content in the gut. Recently, we have identified an important role of 5-HT in the pathogenesis of experimental colitis. 5-HT type 7 (5-HT7) receptor is one of the most recently identified members of the 5-HT receptor family, and dendritic cells express this receptor. In this study, we investigated the effect of blocking 5-HT7 receptor signaling in experimental colitis with a view to develop an improved therapeutic strategy in intestinal inflammatory disorders. Colitis was induced with dextran sulfate sodium (DSS) or dinitrobenzene sulfonic acid (DNBS) in mice treated with selective 5-HT7 receptor antagonist SB-269970, as well as in mice lacking 5-HT7 receptor (5-HT7−/−) and irradiated wild-type mice reconstituted with bone marrow cells harvested from 5-HT7−/− mice. Inhibition of 5-HT7 receptor signaling with SB-269970 ameliorated both acute and chronic colitis induced by DSS. Treatment with SB-269970 resulted in lower clinical disease, histological damage, and proinflammatory cytokine levels compared with vehicle-treated mice post-DSS. Colitis severity was significantly lower in 5-HT7−/− mice and in mice reconstituted with bone marrow cells from 5-HT7−/− mice compared with control mice after DSS colitis. 5-HT7−/− mice also had significantly reduced DNBS-induced colitis. These observations provide us with novel information on the critical role of the 5-HT7 receptor in immune response and inflammation in the gut, and highlight the potential benefit of targeting this receptor to alleviate the severity of intestinal inflammatory disorders such as inflammatory bowel disease.

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Section: Assessment Of Colitis Severitymentioning

confidence: 99%

“…DAI was measured on all 5 d of DSS treatment. Macroscopic damage scores were blindly scored using a previously published scoring system for DSS (40,41) and DNBS-induced colitis (42). Formalin-fixed colon segments were paraffin embedded, and 3-mm sections were stained with H&E to assess for histological damage.…”

Section: Assessment Of Colitis Severitymentioning

confidence: 99%

Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation

Kim

Bridle

Ghia

et al. 2013

The Journal of Immunology

106

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“…Stress favours intestinal inflammation by stimulating the sympathetic nervous system and inhibiting the vagus nerve thus decreasing the cholinergic anti-inflammatory pathway. Stress, through its immune-suppressive function also favours inflammation (Ghia, et al 2006;Bonaz 2010). …”

Section: Stress Effect On Intestinal Inflammationmentioning

confidence: 99%

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Bonaz¹,

Pellissier²,

Sinniger³

et al. 2012

The Amygdala - A Discrete Multitasking Manager

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“…A study made in Germany showed that among the 198 S. aureus investigated from stools, a total of 114 S. aureus strains produced the following enterotoxins in vitro: SEA, 36;SEB, 20;SEC, 19 and SED, 68 (Flemming and Ackerman, 2007). Enterotoxins are excreted and activate intestinal wall receptors, which stimuli reached the vomiting centre through the vague nerve (Ghia et al, 2006;Borison and Wang, 1950). S. aureus may produce other non-identified enterotoxins using serologic methods.…”

Section: Discussionmentioning

confidence: 99%

Toxins and adhesion factors associated with Staphylococcus aureus strains isolated from diarrhoeal patients in Benin

Baba-Moussa¹,

Ahissou²,

Azokpota³

et al. 2010

Afr. J. Biotechnol.

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Staphylococcus aureus is a causative agent of acute and infectious diarrhoea. In Africa, there is no sufficient information on the virulence and the degree of factors produced by its diarrhoea-isolated strains. Clinical features and virulence factors produced by S. aureus isolated from diarrhoeal-patients admitted at the Hospital Hubert Koutoukou Maga (HKM) in Cotonou was investigated. The virulence factors were screened by radial immunoprecipitation and multiplex polymerase chain reaction (PCR). Fifteen antibiotics were tested. Among independent 115 patients examined for diarrhoea, 32 had faeces positive for S. aureus isolated as pure culture. Most of these patients were hospitalized (21/32) and developed aqueous, bloody and painful diarrhoea, after antimicrobial therapy. About 62% were resistant to oxacillin. Genes encoding for clumping factor B and for laminin binding protein were detected in 62% of S. aureus isolates. About 94% of LukE-LukD producing strains have been isolated from patients developing post-antibiotic associated diarrhoea (PAAD). The Panton-Valentine Leucocidin (PVL) was produced by 19% of isolates, all from PAAD. This study points out new data concerning virulence factors and adhesion factor produced by S. aureus strains isolated from diarrhoea in Benin. The culture of the faeces will not always allow the diagnosis. It is important to update a technique, which enables researchers to carry out the virulence factors produced by these bacteria.

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The Vagus Nerve: A Tonic Inhibitory Influence Associated With Inflammatory Bowel Disease in a Murine Model

Cited by 344 publications

References 45 publications

Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation

Targeted Inhibition of Serotonin Type 7 (5-HT7) Receptor Function Modulates Immune Responses and Reduces the Severity of Intestinal Inflammation

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Toxins and adhesion factors associated with Staphylococcus aureus strains isolated from diarrhoeal patients in Benin

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