“…It may also provide a pressurized fluid vehicle for pathogen transport, helping lower genital infections ascend through the cervix into the uterus, fallopian tubes, or abdominal cavity. Douching around the time of ovulation, when the cervical os gapes open and the mucus thins in response to the changing serum estrogen level, has been associated with a higher risk of ascending infection [5,8] . Moreover, douching in the immediate postcoital period may be particularly risky because the douching solution may propel and facilitate the entry of pathogens from the upper vagina into the endocervical canal [15,16] .…”