The Vacuolating Virus of Monkeys

Abstract

A vacuolating virus isolated from uninoculated patas monkey kidney cultures was found to be serologically identical with SV40, a virus previously found in association with rhesus and cynomolgus monkeys. Detection of the patas virus was facilitated when patas cells were exposed to x-ray treatment. Rhesus monkey and human cells were relatively insusceptible to the virus, although it persisted in these cells for a long period of time. Distinct intranuclear inclusions were detected in infected patas cultures 2 to 3 days before cytoplasmic vacuoles were noticeable. Cultures previously infected with PA-57 virus did not affect yields of poliovirus, and doubly infected cells were easily distinguished in stained preparations.

A colposcopical lesion of the uterine cervix frequently associated with papillomavirus type 16 as detected by in situ and southern blot hybridization: A cytohistological correlation study

“…It is reasonable to assume that HPV infection first produces a cytopathic effect in the squamous epithelium, evidenced by koilocytosis and dyskeratosis; this is similar to the lytic or productive phase resulting in characteristic cytopathic effects in other viral infections such as "simian vacuolating virus" (SV-40) (Sweet and Hilleman, 1960;Hsiung and Gaylord, 1961).…”