The Utilization of Partial Orchiectomy in Treating Small Testicular Tumors in the United States

Alanee, Shaheen; Clemons, Joseph; Holland, Bradley; Nutt, Max; Dynda, Danuta

doi:10.23937/2378-3419/1410084

Cited by 3 publications

(4 citation statements)

References 14 publications

(21 reference statements)

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“…Studies have reported that 60–70% of nonpalpable masses of less than 2 cm are nonmalignant lesions such as small benign Leydig or Sertoli cell tumors 2 , 3 , 16 – 18 . No difference was demonstrated in the cancer-specific survival between the RO and TSS groups in 5365 patients with tumors of less than or equal to 2 cm from the Surveillance, Epidemiology, and End Results database 18 , 19 . A report of the German Testicular Cancer Study Group included 73 patients receiving TSS, with a median follow-up of 91 months.…”

Section: Discussionmentioning

confidence: 91%

SAVE Testis-sparing score: a multicenter retrospective study of a novel predictive tool for quantifying testicular tumors

Liu,

Xie,

Gao

et al. 2023

International Journal of Surgery

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Background: Testis-sparing surgery (TSS) is a safe treatment for patients with benign testicular tumors. Presently, assessments for evaluating the suitability of TSS are poorly standardized, partially because testicular anatomical elements cannot be quantitatively described. Materials and Methods: We developed a scoring method known as SAVE testis-sparing score based on four critical and accessible anatomical features of testicular tumor. The SAVE score ranges from 0 to 8 and is divided into four risk classes (low, medium, high, and extremely high) to evaluate the feasibility of TSS, wherein low risk indicates high feasibility and vice versa. This study included 444 testicular tumor patients from eight centers. Among them, 216 patients (model group: 151 patients, validation group: 65 patients) were included in the modeling analysis, and the other 228 patients from children’s centers were included in the proportion analysis. Using retrospective data, patient characteristics associated with surgical methods were identified. Furthermore, multivariate logistic regression model was built quantify the associations between these characteristics and the surgery method. The receiver operator characteristic curve was used to evaluate the classification efficiency of SAVE. Results: The SAVE testis-sparing score includes size (tumor size as maximal diameter), available testicular tissue volume, volume ratio of the tumor to the testis, and the exophytic/endophytic properties of the tumor. The SAVE scoring system accurately classified the suitability of TSS based on the complexity of benign testicular tumors. Conclusion: The SAVE score is a reproducible and robust tool for quantitatively describing the anatomical characteristics of benign testicular tumors and guide the preoperative evaluation of TSS.

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Section: Discussionmentioning

confidence: 91%

SAVE Testis-sparing score: a multicenter retrospective study of a novel predictive tool for quantifying testicular tumors

Liu,

Xie,

Gao

et al. 2023

International Journal of Surgery

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“…Furthermore, secondgeneration AR antagonists cannot completely cure patients with CRPC and ultimately the disease progresses to lethal neuroendocrine prostate cancer (NEPC). The incidence of NEPC has significantly increased with the clinical use of AR inhibitors [34][35][36]. For this reason, we hypothesized that a new type of AR inhibitor, other than AR antagonists, could serve as a unique therapeutic agent for prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Deoxynortryptoquivaline: A unique antiprostate cancer agent

YAMAZAKI,

KAWADA,

MOMOSE

2023

Oncology Research

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The androgen receptor (AR) is a critical target in all the clinical stages of prostate cancer. To identify a new AR inhibitor, we constructed a new screening system using the androgen-dependent growth of prostate cancer cell lines as a screening indicator. We screened 50,000 culture broths of microorganisms using this screening system and found that the fermentation broth produced by a fungus inhibited androgen-dependent growth of human prostate cancer LNCaP cells without cytotoxicity. Purification of this culture medium was performed, and this resulted in deoxynortryptoquivaline (DNT) being identified as a novel inhibitor of AR function. DNT showed potent inhibition of androgen-dependent growth of human prostate cancer LNCaP cells. The AR competitor assay was performed, and DNT did not act as an AR antagonist. However, DNT inhibited AR-dependent transcriptional activity and AR nuclear translocation, it suggested that the suppression of AR function leads to inhibition activity against androgen-dependent growth. Materials and Methods Cell cultureHuman prostate cancer cell lines LNCaP, VCaP, and 22Rv1 were purchased from ATCC (Manassas, VA, USA). LNCaP and 22Rv1cells were grown in RPMI 1640 medium (NISSUI, Tokyo, Japan) containing 10% FBS

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Section: Utilisationmentioning

confidence: 99%

“…Alanee et al, performed a large scale review of primary testicular cancer treatment between 1995-2011; and found that of 5,365 patients identified as having small testicular tumours that would be amenable to PO, only 2% had TSS performed (42). No difference was demonstrated in cancer specific survival between the RO and PO groups in the 5,365 patients with tumours ≤2 cm (42). Low utilisation of PO was also demonstrated in 81 patients with tumours <10 mm in size by Scandura et al, with only 5% undergoing PO rather than RO despite 69% of these cases being identified as benign at histopathology (35).…”

Section: Utilisationmentioning

confidence: 99%

Radical inguinal orchidectomy: the gold standard for initial management of testicular cancer

Koschel

Wong

2020

Transl Androl Urol

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Radical inguinal orchidectomy with division of the spermatic cord at the internal inguinal ring is the gold standard for diagnosis and local treatment of testicular malignancies. The technique is well established and described in detail in this paper, collating methods from various surgical textbooks and articles. We also discuss pre-operative considerations including fertility counselling and potential testicular prosthesis at time of orchidectomy, and the importance of contemplating differential diagnoses such as para-testicular sarcoma and primary testicular lymphoma (PTL) prior to performing radical orchidectomy (RO). The evidence and indications for new surgical techniques to treat local testicular malignancies are also described, including testis sparing surgery (TSS) and spermatic cord sparing orchidectomy.

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The Utilization of Partial Orchiectomy in Treating Small Testicular Tumors in the United States

Cited by 3 publications

References 14 publications

SAVE Testis-sparing score: a multicenter retrospective study of a novel predictive tool for quantifying testicular tumors

SAVE Testis-sparing score: a multicenter retrospective study of a novel predictive tool for quantifying testicular tumors

Deoxynortryptoquivaline: A unique antiprostate cancer agent

Radical inguinal orchidectomy: the gold standard for initial management of testicular cancer

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