The utility of PET/CT in large vessel vasculitis

Shimol, Jennifer Ben; Amital, Howard; Lidar, Merav; Domachevsky, Liran; Shoenfeld, Yehuda; Davidson, Tima

doi:10.1038/s41598-020-73818-2

Cited by 24 publications

(18 citation statements)

References 39 publications

(43 reference statements)

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“…Several case reports have noted TA and CD in the same patient, though such coexistence has been theoretically estimated to occur in only 1 in 10 million individuals [ 3 ]. Although CTA and MRA have been the preferred imaging diagnostic modalities for the past several years, 18-fluorodeoxy-glucose positron emission tomography/computed tomography 18F-FDG PET/CT has been increasingly recognized as an important diagnostic tool [ 4 ]. It is sensitive in showing increased uptake in the aorta and its large proximal branches that are involved in large vessel vasculitis (Giant cell and Takayasu arteritis) and thus it has been strongly recommended as a tool for the early diagnosis of vasculitis by the European League Against Rheumatism (EULAR) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Takayasu arteritis in an adolescent with Crohn’s disease

et al. 2021

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Crohn’s disease (CD) and Takayasu arteritis (TA) are two distinct clinical entities. Τhe likelihood of both diseases coexisting is low, and although CD co-occurs with all types of vasculitis, TA is the most common subtype. Herein, the case of a 15-year-old female, diagnosed with TA following an initial diagnosis of CD, is reported. A review of the literature, including a systemic review of the case reports and case series of children and adolescents up to the age of 21, with both CD and TA, follows the case description. In total, 28 cases of TA and CD were retrieved. The median age of patients was 14.8 years, they were mostly females (72%) and the median time between the two diagnoses was 3.7 years. In the majority of cases, CD was diagnosed first and TA followed. Computed tomography angiography and magnetic resonance angiography were the preferred imaging modalities to assist diagnosis.

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Section: Introductionmentioning

confidence: 99%

Takayasu arteritis in an adolescent with Crohn’s disease

et al. 2021

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“…For example; positron emission tomography (PET)/CT helps confirm the presence of large vessel vasculitis when clinical findings and other imaging findings are nonspecific and it can help in monitoring these patients to detect disease activity [13] , [14] , [15] , [16] .…”

Section: Discussionmentioning

confidence: 99%

Fused 18F-Choline PET/MRI: A potential non-invasive biomarker imaging tool in cerebral vasculitis

Abouzied

Alsalloum

Alharbi

et al. 2021

Radiology Case Reports

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Primary CNS vasculitis is an inflammatory brain disease commonly misdiagnosed affecting the medium and small vessels of the CNS. Due to its broad and non-specific clinical and radiological manifestations; Its diagnosis remains challenging. New diagnostic tools and biomarkers which increase specificity and facilitate the diagnosis for patients with suspected vasculitis are highly desirable to enable physicians to start therapy that can alter its potential aggressive course like immunosuppressant. This case report highlights the potential role of 18 F-choline PET/MRI as a novel imaging tool that might help in the right clinical scenario in the diagnosis of this disease. Furthermore, it speculates on its secondary role in monitoring the response to immunosuppressant therapy.

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“…The intensity of [18F]FDG uptake in the lesions was calculated by standardized uptake values max (SUVmax), by manually generating a region of interest over the pathological lesion. The protocol of the [18F]FDG-PET/CT scans was similar to those described in previously reported studies 33,34 .…”

Section: Methodsmentioning

confidence: 99%

The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype

Nissan

Amit

Baron

et al. 2021

Sci Rep

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We assessed the role of [18F]FDG-PET/CT in identifying and managing cancer of unknown primary site (CUP syndrome). We reviewed [18F]FDG-PET/CT scans of individuals with CUP syndrome recorded in clinical referral letters from 2012 to 2019. We evaluated the identification of primary tumor (PT) by [18F]FDG-PET/CT, according to histological subtype, and the impact on clinical management. The median age was 65 years, 36/64 males (56%). PTs were detected in 28/64 (44%) patients. Detection was significantly lower in patients with squamous cell carcinoma (SCC) than with other histologies combined, p = 0.034. Mean age, mean SUVmax (10.6 ± 6.0) and organ involvement were similar between patients with and without discovered PTs; and between patients with SCC and with other histologies combined. However, those with SCC were less likely than the others to present with multi-lesion involvement, p < 0.001. [18F]FDG-PET/CT interpretations apparently affected treatment of 8/28 (29%) patients with PT detected, and in none of the 35 whose PT was not discovered, p < 0.001. [18F]FDG-PET/CT appeared helpful in detecting PT in almost half the patients with CUP syndrome; the lowest rate was for patients with SCC pathology. PET/CT showed limited overall value in guiding clinical management, however benefited those with discovered PT.

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The utility of PET/CT in large vessel vasculitis

Cited by 24 publications

References 39 publications

Takayasu arteritis in an adolescent with Crohn’s disease

Takayasu arteritis in an adolescent with Crohn’s disease

Fused 18F-Choline PET/MRI: A potential non-invasive biomarker imaging tool in cerebral vasculitis

The usefulness of [18F]FDG-PET/CT in detecting and managing cancers with unknown primary site depends on histological subtype

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