The utility of nasopharyngeal culture in the management of chronic adenoiditis

Marzouk, Haidy; Aynehchi, Behrad B.; Thakkar, Punam; Abramowitz, Tehila; Goldsmith, Ari J.

doi:10.1016/j.ijporl.2012.06.012

Cited by 15 publications

(9 citation statements)

References 8 publications

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“…All children in the present study underwent surgical treatment due to adenoid hypertrophy. Pathogens such as Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis are most commonly detected bacteria in adenoid tissue 24 . Therefore, we assume that colonisation by pathogens was up-regulated due to adenoid hypertrophy, and thus the possible differences between tobacco exposure and pathogens in nasopharynx in children with adenoid hypertrophy could not be manifested.…”

Section: Discussionmentioning

confidence: 99%

The effect of passive smoking on bacterial colonisation of the upper airways and selected laboratory parameters in children

Bugova

Janickova

Uhliarova³

et al. 2018

Acta Otorhinolaryngol Ital

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Section: Discussionmentioning

confidence: 99%

The effect of passive smoking on bacterial colonisation of the upper airways and selected laboratory parameters in children

Bugova

Janickova

Uhliarova³

et al. 2018

Acta Otorhinolaryngol Ital

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“…Although it has been suggested that nasopharyngeal culture has significant utility for the choice of antibiotics in children with chronic adenoiditis [32], there are no data concerning the value of nasopharyngeal cultures in identification of the potential pathogens responsible for inflammation in adenoids and their predictive value for the aetiology of URTIs. In our study, these data were satisfactory only for H. influenzae and S. pneumoniae with high specificity but low sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal vs. adenoid cultures in children undergoing adenoidectomy: prevalence of bacterial pathogens, their interactions and risk factors

et al. 2014

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Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus colonization of the adenoids and nasopharynx in 103 preschool children who underwent adenoidectomy for recurrent upper respiratory tract infections was examined. Bacterial interactions and risk factors for bacterial colonization of the nasopharynx and adenoids, separately, were analysed statistically. The prevalence of simultaneous isolation from both anatomical sites was 45·6% for S. pneumoniae, 29·1% for H. influenzae, 15·5% for M. catarrhalis and 18·4% for S. aureus. Three pathogens were significantly more frequent together from adenoid samples; nasopharyngeal swabs more often yielded a single organism, but without statistical significance. M. catarrhalis and S. aureus significantly more frequently co-existed with S. pneumoniae and H. influenzae than with each other and a positive association of S. pneumoniae and H. influenzae in adenoid samples was evident. Several differences between risk factors for nasopharyngeal and adenoid colonization by the individual pathogens were observed. We conclude that the adenoids and nasopharynx appear to differ substantially in colonization by pathogenic microbes but occurrence of H. influenzae and S. pneumoniae in the nasopharynx could be predictive of upper respiratory tract infections.

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“…The one RCT investigating the use of SsK12 to prevent against chronic adenoiditis exacerbation in children demonstrated a significant protective effect; however, the article is very limited in its detail as to how children were diagnosed. Chronic adenoiditis is not a well-recognized clinical entity and may actually be indistinguishable from sinusitis in clinical practice [45]. Unlike typical pharyngitis/tonsillitis, the pathogens most often implicated in chronic adenoiditis are Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, against which SsK12 has been shown to have partial antagonistic effect [25].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review

Wilcox

Stuart

Leaver

et al. 2019

Clinical Microbiology and Infection

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Background: Sore throat resulting from pharyngotonsillitis is one of the commonest reasons for primary care consultation and inappropriate antibiotic prescription and finding effective alternative treatments is important. Objectives: To review the evidence for using the probiotic Streptococcus salivarius K12 (SsK12) for the prevention or treatment of pharyngotonsillitis. Data Sources: PubMed, Embase, CINAHL and Cochrane Library. Study eligibility criteria: Randomized controlled trials (RCTs). Participants: Adults or children. Interventions: SsK12 as active treatment or prophylaxis, against pharyngotonsillitis. Methods: Literature search. Results: Four articles were identified (1846 participants). All were deemed to be of poor quality using the Cochrane risk-of-bias assessment. Two trials studied SsK12 prophylaxis for streptococcal pharyngitis (children without history of recurrence). One compared daily administration of SsK12 to no treatment over 6 months (n ¼ 222, age 33e45 months), reporting significantly lower incidence in the SsK12 group (16.2% vs. 48.6%, p < 0.01), whereas another placebo-controlled RCT over four school terms (n ¼ 1314, 5 e14 years) found no significant difference (7.8% vs. 8.8%, p 0.34) with SsK12 (administered on school days). Another trial found daily SsK12 to significantly protect children (n ¼ 250, 6e7 years) against chronic adenoiditis exacerbation over 3 months compared to no treatment (71.7% vs. 100%, p < 0.0001). The one placebo-controlled RCT in adults that studied the use of SsK12 for acute pharyngotonsillitis (concurrently with penicillin) showed no significant benefit. In all trials, SsK12 was safe and well tolerated.Conclusions: SsK12 appears safe and well tolerated. However, further RCTs are required to establish its role as a prophylactic therapy, particularly among patients experiencing frequent exacerbations of pharyngitis. In the acute setting, SsK12 is unlikely to be effective if given concurrently with antibiotics; however, further RCTs should establish its role as an alternative to antibiotics in nonsevere cases or when prescribed after antibiotic therapy for the prevention of disease recurrence and/or secondary infection.

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The utility of nasopharyngeal culture in the management of chronic adenoiditis

Cited by 15 publications

References 8 publications

The effect of passive smoking on bacterial colonisation of the upper airways and selected laboratory parameters in children

The effect of passive smoking on bacterial colonisation of the upper airways and selected laboratory parameters in children

Nasopharyngeal vs. adenoid cultures in children undergoing adenoidectomy: prevalence of bacterial pathogens, their interactions and risk factors

Effectiveness of the probiotic Streptococcus salivarius K12 for the treatment and/or prevention of sore throat: a systematic review

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