The utility of monitoring carcinoembyronic antigen during systemic therapy for advanced colorectal cancer.

Immunohistochemical Quantitation of Thymidylate Synthase Expression in Colorectal Cancer Metastases Predicts for Clinical Outcome to Fluorouracil-Based Chemotherapy

“…Other factors have been shown to affect the clinical response to chemotherapy in this disease, including baseline CEA and AP levels, percentage of liver involvement, and initial PS score. 18,35,36,[41][42][43] PS was found to predict for response to chemotherapy, almost to the same degree as TS expression, even in the current study. However, the relationship between PS and response to chemotherapy is independent from the agent that is used, 18 whereas the predictive role of TS may be unique in that groups of patients could be identified who are unresponsive to a specific class of drugs and may be candidates for alternative forms of treatment.…”

“…Initial PS score and baseline CEA, LDH and AP levels have been reported to influence response to chemotherapy in advanced colorectal cancer, independently of the agent used. 18,35,36,[41][42][43] In this cohort, the initial PS score and the baseline CEA level are the only other variables significantly associated with response to chemotherapy (Table 3). Logistic regression analysis of these prognostic factors indicated that intratumoral TS expression was an independent predictor of response to treatment and the relative probability of achieving an objective response among patients with low TS was 5.0 ( Table 4).…”

Clinical significance and prognostic value of serum sHER-2/neu levels in patients with solid tumors

“…In our study, there was no correlation between serum HER-2/neu and CA15-3, CA12-5, CA19-9, CEA, and AFP levels in colorectal and LC groups which may reflect differences in the sensitivity of different tumor markers for the diagnosis of relapse, heterogeneity of tumor-associated antigen expression and variations in the kinetics of epitope release [23].…”

American Society of Clinical Oncology 2009 Clinical Evidence Review on Radiofrequency Ablation of Hepatic Metastases From Colorectal Cancer

“…Carcinoembryonic antigen (CEA) is a clinicopathologic variable associated with local tumor recurrence. 122 In several studies in the systematic review, such as the one by Navarra et al, 49 complete data were available on pre-and post-CEA levels for patients with colorectal liver metastases. Current ASCO guidelines recommend that postoperative serum CEA testing should be performed every 3 months in patients with stage II or III disease for at least 3 years after diagnosis, if the patient is a candidate for resection or systemic therapy.…”