The utility of low-dose hydro-CT using SAFIRE for the diagnosis of gastric cancer

Abstract

Objective: The aim of this retrospective study was to evaluate the application of hydro-CT using sinogram-affirmed iterative reconstruction (SAFIRE) in the diagnosis of gastric cancer. Material/Methods: Low-dose hydro-CT was performed on 30 patients with suspicion of gastric cancer in gastroscopy. The raw data were reconstructed with SAFIRE. Images were retrospectively analyzed by two experienced radiologists in tandem who were blinded to the gastroscopy results. The results of the gastric biopsy were treated as a standard of reference. We compared the diagnostic accuracy of hydro-CT and endoscopy for the diagnosis of gastric cancer using the chi-square test with Yates’ correction. A P value of less than 0.05 was considered statistically significant. Results: The diagnosis of gastric cancer was confirmed in a histopathological examination in 25 (83.3%) patients, while in the remaining 5 cases (16.7%) benign gastric ulceration or gastritis was diagnosed. In 23 cases (92%) a correct diagnosis of gastric cancer was made in hydro-CT. The accuracy of endoscopy was at the level of 83.3%. There was no significant difference in the correctness of the diagnosis of gastric cancer in endoscopy and hydro-CT (p>0.05). For the diagnosis of gastric cancer with hydro-CT, sensitivity of 100%, specificity of 80%, a positive predictive value of 95.8%, and a negative predictive value of 100% were calculated. Conclusions: Low-dose hydro-CT using SAFIRE may be considered as a valuable diagnostic method for the diagnosis of gastric cancer, especially for patients who have contraindications to endoscopy or gastric biopsy.